[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330187-105":59,"doc-detail-330187-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","diagnostic-potential-of-exosomal-extracellular-vesicles-in-oncology","Diagnostic potential of exosomal extracellular vesicles in oncology","","Liquid biopsy enables detection of circulating cancer cells or tumor-derived DNA across cancer stages. The biopsy fluid also contains extracellular vesicles (EVs) including apoptotic bodies, microvesicles, exomeres, and exosomes. Exosomal proteins and nucleic acids such as DNA/RNA can reshape the tumor microenvironment and support cancer progression. Review evidence highlights EV-derived proteins and miRNA biomarkers for multiple cancers, supporting earlier diagnosis, prognosis, and potential therapeutic targets in oncology.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/diagnostic-potential-of-exosomal-extracellular-vesicles-in-oncology/330187/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/diagnostic-potential-of-exosomal-extracellular-vesicles-in-oncology/330187.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does liquid biopsy detect and why are EVs important?","Question",{"text":113,"@type":114},"Liquid biopsy detects circulating cancer cells or tumor-derived DNA in body fluids. The fluid also contains extracellular vesicles, including exosomes, whose biomolecules can reflect cancer biology.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do exosomal proteins and nucleic acids contribute to cancer?",{"text":118,"@type":114},"Exosomal proteins and DNA/RNA can modify the microenvironment and promote cancer progression. They can also support diagnostic and prognostic biomarker development.",{"name":120,"@type":111,"acceptedAnswer":121},"Which cancer types are covered by EV biomarker evidence in the review?",{"text":122,"@type":114},"The review highlights EV protein and miRNA biomarkers for cancers including melanoma, glioma, breast, pancreatic, hepatic, cervical, prostate, colon, and some hematological malignancies.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},330187,1790015008,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","Andre et al. BMC Cancer (2024) 24:322 [https://doi.org/10.1186/s12885-024-11819-4](https://doi.org/10.1186/s12885-024-11819-4)  \nBMC Cancer  \n REVIEW Open Access  \nDiagnostic potential of exosomal extracellular vesicles in oncology  \nMickensone Andre1, Allen Caobi1, Jana S. Miles 1, Arti Vashist1, Marco A. Ruiz 1,2 and Andrea D. Raymond 1*  \nAbstract  \nLiquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages of cancer. The  \nfluid from these biopsies contains extracellular vesicles (EVs), such as apoptotic bodies, microvesicles, exomeres, and exosomes. Exosomes contain proteins and nucleic acids (DNA/RNA) that can modify the microenvironment and promote cancer progression, playing significant roles in cancer pathology. Clinically, the proteins and nucleic acids within the exosomes from liquid biopsies can be biomarkers for the detection and prognosis of cancer. Wereview EVs protein and miRNA biomarkers identified for select cancers, specifically melanoma, glioma, breast, pancreatic, hepatic, cervical, prostate colon, and some hematological malignancies. Overall, this review demonstrates that EV biomolecules have great potential to expand the diagnostic and prognostic biomarkers used in Oncology; ultimately, EVs could lead to earlier detection and novel therapeutic targets.  \nClinical implications  \nEVs represent a new paradigm in cancer diagnostics and therapeutics. The potential use of exosomal contents as biomarkers for diagnostic and prognostic indicators may facilitate cancer management. Non-invasive liquid biopsy is helpful, especially when the tumor is difficult to reach, such as in pancreatic adenocarcinoma. Moreover, another advantage of using minimally invasive liquid biopsy is that monitoring becomes more manageable. Identifying tumor-derived exosomal proteins and microRNAs would allow a more personalized approach to detecting cancer and improving treatment.  \nKeywords Extracellular vesicles, Biomarkers, MicroRNA, Exosomes, Cancer, Daignostics, Therapeutics  \nIntroduction  \nA liquid biopsy is a non-invasive approach to identify circulating tumor cells or tumor-cell-derived-DNA in bodily fluids such as blood, urine, saliva, and cerebrospinal fluid (CSF). Liquid biopsy has been used for early detection of cancer, responsiveness to treatment, and detection of cancer remission/re-occurrence [1]. Among the  \n*Correspondence: Andrea D. Raymond [adraymon@fiu.edu](adraymon@fiu.edu)  \n1 Herbert Wertheim College of Medicine at, Department of Immunology and Nanomedicine, Florida International University, Miami 33199, FL, USA  \n2 Medical Oncology, Baptist Health Miami Cancer Institute, Miami 33176, FL, USA  \ncontents in a liquid biopsy, included are tumor DNA and extracellular vesicles (EVs) released by both healthy and tumor cells. Exosomes are a subtype of EVs released from most cell types into various bodily fluids, including urine, saliva, breast milk, and blood [2–4]. Exosomes tend to be near 30–150 nm in diameter and possess a cholesterolrich lipid bilayer membrane that encloses biomolecules such as RNAs and proteins (Fig. 1). Exosomes have many functions, such as the transportation of biomolecules and cell-to-cell communication that can elicit functional responses in recipient cells that uptake them [2, 5–7]. Tumor-derived exosomes (TEXs) have multiple roles in cancer progression, and mounting evidence suggests that exosomes may also have clinical therapeutic relevance [1, 8–10]. These observations are all due in part to the  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’","cbCaiir5jAGYFI7X","https://ap.wps.com/l/cbCaiir5jAGYFI7X","pdf",1409481,15,"English","# Abstract\n# Clinical implications\n# Keywords\n# Introduction","[{\"question\":\"What does liquid biopsy detect and why are EVs important?\",\"answer\":\"Liquid biopsy detects circulating cancer cells or tumor-derived DNA in body fluids. The fluid also contains extracellular vesicles, including exosomes, whose biomolecules can reflect cancer biology.\"},{\"question\":\"How do exosomal proteins and nucleic acids contribute to cancer?\",\"answer\":\"Exosomal proteins and DNA/RNA can modify the microenvironment and promote cancer progression. They can also support diagnostic and prognostic biomarker development.\"},{\"question\":\"Which cancer types are covered by EV biomarker evidence in the review?\",\"answer\":\"The review highlights EV protein and miRNA biomarkers for cancers including melanoma, glioma, breast, pancreatic, hepatic, cervical, prostate, colon, and some hematological malignancies.\"}]","Diagnostic potential of exosomal extracellular vesicles in oncology | PDF",1789987554,38]