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Materials and Methods: Genotyping of the ALDH2 rs671 single nucleotide polymorphism was performed in 298 HCC patients and 889 healthy controls, with associations evaluated stratified by sex and alcohol consumption status. Results: The rs671 variant genotype distribution differed significantly between cases and controls, and logistic regression showed increased HCC risk for AG and AA versus GG, with stronger effects in males and non-alcohol drinkers. Conclusion: HCC risk is influenced by ALDH2 genotype, modified by sex and alcohol intake.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/diagnostic-impacts-of-aldehyde-dehydrogenase-2-genetic-variants-on-hepatocellular-carcinoma-susceptibility/336694/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/diagnostic-impacts-of-aldehyde-dehydrogenase-2-genetic-variants-on-hepatocellular-carcinoma-susceptibility/336694.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about ALDH2 and HCC?","Question",{"text":112,"@type":113},"The study evaluates how alcohol consumption and the ALDH2 genotype relate to hepatocellular carcinoma susceptibility, focusing on whether genetic variation changes HCC risk.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was ALDH2 genetic variation measured in the participants?",{"text":117,"@type":113},"Researchers genotyped the ALDH2 rs671 single nucleotide polymorphism in 298 HCC patients and 889 healthy control participants.",{"name":119,"@type":110,"acceptedAnswer":120},"Which ALDH2 genotypes were associated with higher HCC risk and in whom?",{"text":121,"@type":113},"Compared with the GG genotype, AG and AA genotypes were associated with increased HCC risk; AA carriers showed significantly higher risk among males and among non-alcohol drinkers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336694,1790822637,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","4: 579-585 (2024) doi: 10.21873/cdp.10366  \nDiagnostic Impacts of Aldehyde Dehydrogenase 2 Genetic Variants on Hepatocellular Carcinoma Susceptibility  \nYU-TING CHIN 1,2* , MING-HSIEN WU3,4* , HOU-YU SHIH 1,2* , CHIA-WEN TSAI 1,2 , JEN-SHENG PEI5 , TAO-WEI KE2 , YUN-CHI WANG 1,2 , YI-CHIH HUNG2 ,  \nJAW-CHYUN CHEN6 , DA-TIAN BAU 1,2,7 and WEN-SHIN CHANG 1,2  \n1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R. O. C. ;  \n2Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;  \n3Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R. O. C. ;  \n4National Defense Medical Center, Taipei, Taiwan, R. O. C. ;  \n5Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R. O. C. ;  \n6Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.;  \n7Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R. O. C.  \nAbstract. Background/Aim: The role of alcohol consumption and aldehyde dehydrogenase 2 (ALDH2) genotype in hepatocellular carcinoma (HCC) development remains uncertain. Materials and Methods: We conducted genotyping of the ALDH2 rs671 single nucleotide polymorphism in 298 patients with HCC and 889 non-cancerous healthy controls. We assessed associations stratified by sex and alcohol consumption status. Results: Distribution of ALDH2 rs671 variant genotypes differed significantly between HCC patients and controls (p trend=0.0311) . Logistic regression analyses indicated that compared to the wild-type GG genotype, the heterozygous variant AG genotype and homozygous variant AA genotype  \n*These Authors contributed equally to this study.  \nCorrespondence to: Da-Tian Bau and Wen-Shin Chang, Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C. Tel: +886 422053366 Ext. 5805, e-mail: [halittlemelon@hotmail.com](halittlemelon@hotmail.com) (W-S Chang); [artbau2@gmail.com](artbau2@gmail.com) (D-T Bau)  \nKey Words: Alcohol drinking, aldehyde dehydrogenase 2 (ALDH2), genotype, hepatocellular carcinoma, polymorphism.  \n©2024 International Institute of Anticancer Research [www.iiar-anticancer.org](www.iiar-anticancer.org)  \nThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license ([https://creativecommons.org/licenses/by-nc-nd/4.0](https://creativecommons.org/licenses/by-nc-nd/4.0)).  \nconferred 1.22-and 1.77-fold increases in HCC risk (p=0.1794 and 0.0150, respectively). Allelic frequency analysis showed that the A allele was associated with a 1.29-fold increased HCC risk (p=0.0123) . Additionally, AA genotype carriers had significantly higher HCC risk than GG genotype carriers among males (p=0.0145) and non-alcohol drinkers (p\u003C0.001) . Conclusion: HCC risk is influenced by ALDH2 genotype, with effects modified by sex and alcohol consumption. Particularly, individuals with the ALDH2 rs671 AA genotype should avoid alcohol consumption, especially males.  \nHepatocellular carcinoma (HCC) ranks sixth in global cancer prevalence and third in cancer-related mortality (1-3) . Despite significant advancements in systematic therapies for HCC, including targeted therapy, immune checkpoint inhibitors, and intravenous chemotherapy, the 5-year recurrence rate remains high at 75%(4, 5). HCC represents a formidable global public health challenge (6) . Recently, genome-wide (7, 8) and candidate gene studies (9-12), have revealed several potential diagnostic biomarkers for HCC. Nevertheless, identifying a clinically validated diagnostic marker remains challenging (13) . Aldehyde dehydrogenase 2 (ALDH2) is known for its role in ethanol metabolism, primarily expressed in liver mitochondria where it catalyzes the conv","cbCaieVKq9fboJyw","https://ap.wps.com/l/cbCaieVKq9fboJyw","pdf",549878,"English","# Abstract\n## Background/Aim\n## Materials and Methods\n## Results\n## Conclusion","[{\"question\":\"What question does the study address about ALDH2 and HCC?\",\"answer\":\"The study evaluates how alcohol consumption and the ALDH2 genotype relate to hepatocellular carcinoma susceptibility, focusing on whether genetic variation changes HCC risk.\"},{\"question\":\"How was ALDH2 genetic variation measured in the participants?\",\"answer\":\"Researchers genotyped the ALDH2 rs671 single nucleotide polymorphism in 298 HCC patients and 889 healthy control participants.\"},{\"question\":\"Which ALDH2 genotypes were associated with higher HCC risk and in whom?\",\"answer\":\"Compared with the GG genotype, AG and AA genotypes were associated with increased HCC risk; AA carriers showed significantly higher risk among males and among non-alcohol drinkers.\"}]","Diagnostic Impacts of Aldehyde Dehydrogenase 2 Genetic Variants on Hepatocellular Carcinoma Susceptibility | PDF",1790016216,18]