[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-461362-105":59,"doc-detail-461362-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","diagnostic-challenges-of-ohvira-syndrome-a-case-report","Diagnostic Challenges of OHVIRA Syndrome - A Case Report","","Herlyn–Werner–Wunderlich (HWW) syndrome, also termed OHVIRA (Obstructed HemiVagina and Ipsilateral Renal Anomaly), is a rare congenital disorder of the female urogenital system defined by uterine duplication, unilateral vaginal obstruction, and ipsilateral renal agenesis. Symptoms frequently appear after menarche with pelvic mass, dysmenorrhea, and chronic pelvic pain, contributing to delayed recognition. A 13-year-old patient received imaging-based diagnosis; surgery including vaginal septum incision and evacuation of accumulated blood resolved symptoms and restored reproductive tract patency.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/diagnostic-challenges-of-ohvira-syndrome-a-case-report/461362/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/diagnostic-challenges-of-ohvira-syndrome-a-case-report/461362.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is OHVIRA syndrome and how does it affect the female urogenital system?","Question",{"text":112,"@type":113},"OHVIRA syndrome is also known as HWW syndrome and is characterized by uterine duplication, unilateral vaginal obstruction, and ipsilateral renal agenesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is OHVIRA syndrome often diagnosed late?",{"text":117,"@type":113},"The condition often remains undiagnosed in childhood and symptoms typically emerge after menarche, when cyclic pain and related findings become apparent.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment approach was used in the case report and what was the outcome?",{"text":121,"@type":113},"Surgical incision of the vaginal septum with evacuation of accumulated blood was performed, leading to symptom resolution and restoration of reproductive tract patency.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461362,1791291467,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Case Report  \nDiagnostic Challenges of OHVIRA Syndrome—A Case Report  \nPaulina Tomecka 1, *, Adam Jagodzi ´nski 2,*, Justyna Łuczak 3, Łukasz Waszczuk 4 and Marek Murawski 2  \nAcademic Editor: Alberto Revelli  \nReceived: 15 November 2025  \nRevised: 18 December 2025  \nAccepted: 22 December 2025  \nPublished: 26 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland  \n2 Clinical Department of Gynecologic Surgery and Oncology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland; [marek.murawski@umw.edu.pl](marek.murawski@umw.edu.pl)  \n3 Pediatric Surgery and Urology Department, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland; [justyna.luczak@umw.edu.pl](justyna.luczak@umw.edu.pl)  \n4 Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland; [lukasz.waszczuk@umw.edu.pl](lukasz.waszczuk@umw.edu.pl)  \n* Correspondence: [tomeckapaulina@gmail.com](tomeckapaulina@gmail.com) (P.T.); [a.jagodzinski@umw.edu.pl](a.jagodzinski@umw.edu.pl) (A.J.); Tel.: +48-661-656-231 (P.T.)  \nAbstract  \nBackground and Clinical Significance: Herlyn–Werner–Wunderlich (HWW) syndrome, also known as OHVIRA syndrome (Obstructed HemiVagina and Ipsilateral Renal Anomaly), is a rare congenital anomaly of the female urogenital system characterized by uterine duplication, unilateral vaginal obstruction, and renal agenesis on the same side. The condition often remains undiagnosed until adolescence, when it presents with palpable pelvic mass, dysmenorrhea, and chronic pelvic pain. Case report: We present the case of a 13-year-old female patient diagnosed with OHVIRA syndrome following imaging studies. Surgical treatment involved incision of the vaginal septum and evacuation of accumulated blood, leading to symptom resolution and restoration of reproductive tract patency. Conclusions: This article discusses the clinical characteristics, diagnostic challenges, and the importance of early surgical intervention, emphasizing the necessity of considering this syndrome in the differential diagnosis of adolescent females with cyclic abdominal pain and renal anomalies. Early diagnosis and treatment can prevent severe health complications and improve both patients’ quality of life and fertility.  \nKeywords: OHVIRA syndrome; uterine duplication; unilateral vaginal obstruction; renalagenesis; congenital anomalies of the female reproductive system  \n1. Introduction  \nNearly 7% of girls are born with congenital abnormalities affecting female reproductive system [1] . These anomalies may appear alone or along with the defects in the kidneys, bladder, or anorectal region [2] . Herlyn–Werner–Wunderlich (HWW) syndrome is a rareurogenital disorder linked to Müllerian and mesonephric duct malformations, defined by a classic triad of developmental defects: uterine duplication, unilateral vaginal obstruction, and ipsilateral renal agenesis [3] . Although HWW syndrome has traditionally been considered extremely rare, with some clinical reports indicating an incidence of approximately 1 in 1,000,000 females, it is increasingly recognized as underdiagnosed [4] . The syndrome is estimated to represent 0.1–3.8% of Müllerian duct anomalies, though its true prevalence within the general population remains undetermined [5,6] . This underrecognition is likely due to variable clinical presentation and the delayed onset of symptoms, which often become apparent only after menarche [7] . Notably, a retrospective case series identified HWW  \nsyndrome as the most commonly diagnosed obstructive Müllerian anomaly in adolescents presenting after menarche [8] .  \nHWW syndrome, also called Obstructed HemiVagina and Ipsilateral Renal Anomaly (OHVIRA) syndrome, has been","cbCaif4uuYE6OK7A","https://ap.wps.com/l/cbCaif4uuYE6OK7A","pdf",1775926,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"What is OHVIRA syndrome and how does it affect the female urogenital system?\",\"answer\":\"OHVIRA syndrome is also known as HWW syndrome and is characterized by uterine duplication, unilateral vaginal obstruction, and ipsilateral renal agenesis.\"},{\"question\":\"Why is OHVIRA syndrome often diagnosed late?\",\"answer\":\"The condition often remains undiagnosed in childhood and symptoms typically emerge after menarche, when cyclic pain and related findings become apparent.\"},{\"question\":\"What treatment approach was used in the case report and what was the outcome?\",\"answer\":\"Surgical incision of the vaginal septum with evacuation of accumulated blood was performed, leading to symptom resolution and restoration of reproductive tract patency.\"}]","Diagnostic Challenges of OHVIRA Syndrome - A Case Report | PDF",1790761429]