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Clinical jaundice is defined as occurring when bilirubin exceeds 2mg/dL. The document differentiates between conjugated (direct) and unconjugated (indirect) hyperbilirubinemia. Conjugated bilirubin is described as tightly bound to albumin, not water-soluble, and excreted in urine, leading to dark urine. Unconjugated bilirubin is loosely bound to albumin, water-soluble, and can cross the blood-brain barrier, potentially causing neurologic deficits. The document includes a flowchart illustrating the diagnostic pathway, starting with elevated serum bilirubin and branching into unconjugated and conjugated hyperbilirubinemia. Further steps involve checking for hemolysis, assessing anemia, evaluating liver function tests (LFTs), and examining the pattern of abnormalities. Different patterns, such as hepatocellular and cholestatic, are discussed, along with their associated causes like viral hepatitis, alcoholic liver disease, autoimmune conditions, gallstones, and biliary obstruction. It also mentions common abbreviations like HF (heart failure), MRCP (magnetic resonance cholangiopancreatography), NAFLD (nonalcoholic fatty liver disease), and TPN (total parenteral nutrition).",{"@graph":69,"@context":105},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/diagnostic-approach-to-hyperbilirubinemia/26860/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/diagnostic-approach-to-hyperbilirubinemia/26860.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-18","2026-05-08",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction","https://schema.org",{"og:url":107,"og:type":108,"og:title":65,"og:site_name":95,"og:description":67},"https://docshare.wps.com/document/diagnostic-approach-to-hyperbilirubinemia/26860","article",{"robots":110,"canonical":107},"index,follow",{"doc_id":112,"site_id":62},26860,1778200113,{"code":4,"msg":5,"data":115},{"doc_id":112,"user_id":116,"nickname":92,"user_avatar":117,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":122,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":123,"seo_description":67,"update_tm":113,"read_time":81},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","cbCairqE7g4pI2g1","https://ap.wps.com/l/cbCairqE7g4pI2g1","pdf",2463541,"English","Diagnostic approach to hyperbilirubinemia | PDF"]