[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-436174-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-436174-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","diagnosis-and-treatment-of-syphilitic-uveitis-taiwan-experts-consensus","Diagnosis and treatment of syphilitic uveitis: Taiwan experts consensus","","A recent resurgence in syphilis incidence has renewed interest in this historically complex disease. Syphilitic uveitis remains difficult to diagnose and manage because clinical manifestations vary widely across syphilis infection stages. The document provides expert recommendations on clinical manifestations, diagnosis, and treatment for patients with syphilitic uveitis in Taiwan. Recommendations are grounded in an expert meeting and consensus among experienced uveitis specialists within the Taiwan Ocular Inflammation Society.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/diagnosis-and-treatment-of-syphilitic-uveitis-taiwan-experts-consensus/436174/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/diagnosis-and-treatment-of-syphilitic-uveitis-taiwan-experts-consensus/436174.png","ImageObject",300,407,{"name":42,"@type":43},"Levi","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is syphilitic uveitis considered challenging to diagnose?","Question",{"text":63,"@type":64},"Syphilitic uveitis has variable clinical manifestations and diagnostic complexity, making ocular disease patterns hard to interpret. Identifying Treponema pallidum from ocular tissue is also difficult.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What are the main diagnostic approaches discussed for syphilitic uveitis?",{"text":68,"@type":64},"Diagnosis relies on serological tests, which remain the mainstay. Sensitivity and specificity vary by test type and by the syphilis stage.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment is recommended, and what is the risk of incorrect management?",{"text":72,"@type":64},"Treatment is based on penicillin. Inappropriate or delayed treatment, often due to misdiagnosis, may lead to permanent vision loss.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},436174,1790713574,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J Chin MedAssoc  \nReview ARticle  \nDiagnosis and treatment of syphilitic uveitis: Taiwan experts consensus  \nYen-Chih Chena,b,c, Chang-Ping Lind, Chang-Hao Yangd,e, Yih-Shiou Hwangf,g,h,i, Cheng-Kuo Chengj,k, De-Kuang Hwangl,m, Po-Ting Yehd, Yung-Ray Hsun, Shwu-Jiuan Sheuo,p,*, San-Ni Chenq,r,*  \naDepartment of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan, ROC; bDepartment of Ophthalmology, Yunlin Christian Hospital, Yunlin, Taiwan, ROC; cDepartment of Optometry, Central Taiwan University of Science and Technology,  \nTaichung, Taiwan, ROC; dDepartment of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC; eDepartment of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC; fDepartment of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; gCollege of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC; hDepartment of Ophthalmology, Chang Gung Memorial Hospital, Xiamen, China; iDepartment of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung, Taiwan, ROC; jDepartment of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC; kDepartment of Medicine, School of Medicine, Catholic Fu-Jen University, New Taipei City, Taiwan, ROC; lDepartment of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; mDepartment of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; nDepartment of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC; oDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Taiwan, ROC; pDepartment of Ophthalmology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; qDepartment of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC; rDepartment of Medication, China Medical University, Taichung, Taiwan, ROC  \nAbstract  \nA recent resurgence in the incidence of syphilis has sparked a new interest in this old disease. Syphilitic uveitis remains a challenging disease, among the variable syphilis infections, due to the diagnostic complexity and the wide clinical manifestations. Here, we provide recommendations regarding clinical manifestations, diagnosis, and treatment for patients with syphilitic uveitis in Taiwan based on an expert meeting and consensus from experienced uveitis specialists.  \nKeywords: Ocular syphilis; Syphilitic uveitis; Taiwan expert consensus  \n1. INTRODUCTION  \nSyphilis is a sexually transmitted disease caused by the spirochete bacterium Treponema pallidum. Known as the “great masquerader,” syphilis can mimic many diseases due to its extensive range of clinical manifestations.1,2 Globally, 12 million new syphilis cases are estimated to be added annually, with more than 90% from developing countries.3 A significant increase has been recently observed in the syphilis rate since 2001. A study from the United Kingdom revealed that the national syphilis rate soared up to 8.7 cases per 100 000 populations in 2015 to 2016, particularly among patients infected with human immunodeficiency virus (HIV) and males having sex with males (MSM) .4 A total of 9413 syphilis-confirmed cases were reported in Taiwan in 2021, in which the ratio of male to female was 11:1 . Syphilis  \n*Address correspondence. Dr. Shwu-Jiuan Sheu, Department of Ophthalmology, Kaohsiung Medical University Hospital, 100, Tzyou 1st Road, Kaohsiung 807, Taiwan, [ROC. E-mail address: sjiuansheu@gmail.com](ROC. E-mail address: sjiuansheu@gmail.com) (S.-J. Sheu); Dr. San-Ni Chen, Department of Ophthalmology, China Medical University Hospital, 91, Hsueh Shih Road, Taichung 404, Taiwan, ROC. E-mail address: sanchen52@ [gmail.com](gmail.com) (S.-N. Chen).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2024) 87: 659-663.  \nReceived Sep","cbCaiis6y0De5uz2","https://ap.wps.com/l/cbCaiis6y0De5uz2","pdf",520543,"English","# Introduction\n# Clinical manifestations\n# Diagnosis\n# Treatment\n# Expert consensus and recommendations","[{\"question\":\"Why is syphilitic uveitis considered challenging to diagnose?\",\"answer\":\"Syphilitic uveitis has variable clinical manifestations and diagnostic complexity, making ocular disease patterns hard to interpret. Identifying Treponema pallidum from ocular tissue is also difficult.\"},{\"question\":\"What are the main diagnostic approaches discussed for syphilitic uveitis?\",\"answer\":\"Diagnosis relies on serological tests, which remain the mainstay. Sensitivity and specificity vary by test type and by the syphilis stage.\"},{\"question\":\"What treatment is recommended, and what is the risk of incorrect management?\",\"answer\":\"Treatment is based on penicillin. Inappropriate or delayed treatment, often due to misdiagnosis, may lead to permanent vision loss.\"}]","Diagnosis and treatment of syphilitic uveitis: Taiwan experts consensus | PDF",1790677025,13]