[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-369733-105":59,"doc-detail-369733-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","diagnosis-and-therapeutic-targeting-of-quiescent-cancer-cells-road-to-conquer-cancer-recurrence","Diagnosis and therapeutic targeting of quiescent cancer cells - road to conquer cancer recurrence","","Quiescent cancer cells (QCCs) are therapy-resistant, non-proliferating remnants that persist after anticancer treatment and are widely considered the initiating source of cancer recurrence. Their microscopic nature makes in vivo and patient-level tracing and analysis difficult, leaving QCC biomarkers and the mechanisms of reversible reactivation poorly understood and limiting diagnostics and targeted therapies. This invited mini review summarizes current basic and clinical insights and discusses strategies aimed at targeted elimination of residual QCCs to prevent relapse.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/diagnosis-and-therapeutic-targeting-of-quiescent-cancer-cells-road-to-conquer-cancer-recurrence/369733/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/diagnosis-and-therapeutic-targeting-of-quiescent-cancer-cells-road-to-conquer-cancer-recurrence/369733.png","ImageObject",300,407,{"name":92,"@type":93},"Stanford","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are quiescent cancer cells (QCCs) considered important for cancer recurrence?","Question",{"text":112,"@type":113},"QCCs persist after therapy in a non-proliferating, treatment-resistant state. They can later regain proliferative activity and act as “seeds” for recurrence.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What makes diagnosis of QCCs in vivo and in patients difficult?",{"text":117,"@type":113},"QCCs are microscopic residual subsets, and reliable biomarkers and mechanisms for their reversible reactivation remain poorly understood, limiting effective diagnostic tracing.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the review propose to address cancer recurrence targeting QCCs?",{"text":121,"@type":113},"It reviews current understanding of QCCs and diagnostic efforts and explores potential strategies for targeted elimination of residual QCCs to prevent relapse.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},369733,1791112823,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336477552062,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","BMB Reports  \nBMB Rep. 2025; 58(7): 277-287  \n[www.bmbreports.org](www.bmbreports.org)  \n Invited Mini Review   \nDiagnosis and therapeutic targeting of quiescent cancer cells: road to conquer cancer recurrence  \nMoon Jong Kim1,2, *  \n1Department of Life Science, Gachon University, Seongnam 13120, 2Department of Health Science and Technology, GAIHST, Lee Gil Ya Cancer and Diabetes Institute, Incheon 21999, Korea  \nQuiescent cancer cells (QCCs) are considered an origin of cancer recurrence and present an ongoing challenge in cancer treatment. Following anti-cancer therapy, non-proliferating, therapy-resistant QCCs have been detected as subsets of residual cancer cells within patients. Clinicians and researchers widely believe that these minimal residual QCCs can eventually regain proliferative activity, acting as “seeds” for cancer recurrence. Despite the significance of QCCs, tracing and analyzing these microscopic residual cells in vivo models and patients remains extremely challenging, limiting our understanding. Consequently, reliable biomarkers for QCCs and the mechanisms underlying their ‘reversible’ reactivation are still poorly understood. This knowledge gap has hindered the development of diagnosticsand targeted therapies for QCCs. The absence of diagnostic tools for QCCs also complicates predicting cancer relapse and determining the optimal duration of anti-cancer treatment. Moreover, without strategies to eradicate QCCs, preventing cancer recurrence remains elusive. This review aims to provide an overview of the current understanding of QCCs and related diagnostic efforts in both basic and clinical research. Additionally, potential strategies for the targeted elimination of QCCs are explored. Focused research and clinical attention to diagnosing and eradicating residual QCCs are essential for preventing cancer recurrence and ultimately conquering this deadly disease.[BMB Reports 2025; 58(7): 277-287]  \nINTRODUCTION  \nThe development of anticancer chemotherapy, targeted therapy, and immunotherapy has significantly improved treatment outcomes and enhanced survival rates for several cancer types (1) .  \n*Corresponding author. Tel: +82-32-899-6112; Fax: +82-32-899- 6039; [E-mail: moonjongkim7@gachon.ac.kr](E-mail: moonjongkim7@gachon.ac.kr)  \n[https://doi.org/10.5483/BMBRep.2025-0007](https://doi.org/10.5483/BMBRep.2025-0007)  \nReceived 19 December 2024, Revised 5 February 2025, Accepted 7 March 2025, Published online 31 March 2025  \nKeywords: Cancer recurrence, Diagnostics, Minimal residual disease (MRD), Quiescent cancer cells (QCCs), Targeted therapy  \nHowever, despite these advancements, increases in survival rates remain modest or minimal for certain cancers (1) . Notably, these incurable cancers often exhibit alarmingly high recurrence rates within 1 to 5 years: lung cancer ( ∼60%) (2, 3), pancreatic cancer ( ∼50%) (4, 5), liver cancer (50-80%) (6), cholangiocarcinoma (60-70%) (7, 8), acute myeloid leukemia ( ∼50%) (9), gastric cancer ( ∼60%) (10), colorectal cancer ( ∼25%) (11), etc. (Fig. 1) . Furthermore, some cancers, such as ovarian cancer ( ∼85%) (12, 13) and glioblastoma (100%) (14, 15), have an almost inevitable recurrence (Fig. 1) . These findings underscore the urgent need for strategies to prevent cancer recurrence, which is essential for achieving curative treatment and improving patient survival.  \nIn some cases of recurrent cancer, the disease is even initially diagnosed as being in complete remission following first-line treatment, however, recurrence is eventually observed. These high recurrence rates, combined with incomplete diagnostics, can significantly diminish patients’ hopes for a cure. Furthermore, to mitigate the risk of relapse and enhance treatment efficacy, adjuvant therapies are often administered over extended periods. However, prolonged treatment can negatively impact patients’quality of life and, in some cases, lead to overtreatment.  \nGiven the persistently high recurrence rates, a f","cbCaitTaoRm7IDGt","https://ap.wps.com/l/cbCaitTaoRm7IDGt","pdf",5134009,11,"English","# Introduction\n## Challenges of cancer recurrence and limited diagnostics\n## Minimal residual disease (MRD) and quiescent cancer cells (QCCs)\n# Quiescent cancer cells: phantom of menace","[{\"question\":\"Why are quiescent cancer cells (QCCs) considered important for cancer recurrence?\",\"answer\":\"QCCs persist after therapy in a non-proliferating, treatment-resistant state. They can later regain proliferative activity and act as “seeds” for recurrence.\"},{\"question\":\"What makes diagnosis of QCCs in vivo and in patients difficult?\",\"answer\":\"QCCs are microscopic residual subsets, and reliable biomarkers and mechanisms for their reversible reactivation remain poorly understood, limiting effective diagnostic tracing.\"},{\"question\":\"How does the review propose to address cancer recurrence targeting QCCs?\",\"answer\":\"It reviews current understanding of QCCs and diagnostic efforts and explores potential strategies for targeted elimination of residual QCCs to prevent relapse.\"}]","Diagnosis and therapeutic targeting of quiescent cancer cells - road to conquer cancer recurrence | PDF",1790184274,28]