[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-152607-en":3,"doc-seo-152607-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},152607,1099513958607,"Jiven","https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399",7,"Healthcare","Diagnosis and Management of Cerebral Small Vessel Disease","Cerebral small vessel disease (CSVD) is a frequent neurologic condition linked to substantial mortality and disability through its contributions to ischemic and hemorrhagic stroke risk, silent infarcts, and later cognitive decline. Despite centuries of recognition, prevention and management still face knowledge gaps. This review summarizes current understanding, highlights radiographic diagnostic criteria, and emphasizes blood pressure control as the best-established stroke-prevention strategy, supported by recent long-term targets.","Diagnosis and Management of Cerebral Small Vessel Disease  \nBy Anjail Sharrief, MD, MPH, FAHA  \nABSTRACT  \nOBJECTIVE: Cerebral small vessel disease (CSVD) is a common neurologic condition that contributes to considerable mortality and disability because of its impact on ischemic and hemorrhagic stroke risk and dementia. While attributes of the disease have been recognized for over two centuries, gaps in knowledge remain related to its prevention and management. The purpose of this review is to provide an overview of the current state of knowledge for CSVD.  \nLATEST DEVELOPMENTS: CSVD can be recognized by well-defined radiographic criteria, but the pathogenic mechanism behind the disease is unclear. Hypertension control remains the best-known strategy for stroke prevention in patients with CSVD, and recent guidelines provide a  \nlong-term blood pressure target of less than 130/80 mm Hg for patients with ischemic and hemorrhagic stroke, including those with stroke related to CSVD. Cerebral amyloid angiopathy is the second leading cause of intracerebral hemorrhage and may be increasingly recognized because of newer, more sensitive imaging modalities. Transient focal neurologic episodes is a relatively new term used to describe “amyloid spells.”Guidance on distinguishing these events from seizures and transient ischemic attacks has been published.  \nESSENTIAL POINTS: CSVD is prevalent and will likely be encountered by all neurologists in clinical practice. It is important for neurologists to be able to recognize CSVD, both radiographically and clinically, and to counsel patients on the prevention of disease progression. Blood pressure control is especially relevant, and strategies are needed to improve blood pressure control for primary and secondary stroke prevention in patients with CSVD.  \nINTRODUCTION  \nC  \nerebral small vessel disease (CSVD) is one of the most common clinical conditions that a neurologist will encounter. CSVD is associated with an increased risk of clinical ischemic and hemorrhagic stroke, silent infarcts, and cognitive decline and dementia. It has well-defined radiographic features and various  \nclinical presentations. Despite its increasing prevalence with the aging  \nREVIEW ARTICLE  \n􀀁  \nCONTINUUM AUDIO INTERVIEW AVAILABLE ONLINE  \nCITE AS:  \nCONTINUUM (MIN NEA P M INN) 2023;29(2, CEREBROVASCULAR DISEASE):501 –518.  \nAddress correspondence to Anjail Sharrief, 6431 Fannin St, MSB 7.110, Houston, TX 77030, [Anjail.Z.Sharrief@uth.tmc.edu](Anjail.Z.Sharrief@uth.tmc.edu).  \nRELATIONSHIP DISCLOSURE: The institution of Dr Sharrief has received research support from the National Institutes of Health and the University of Houston. Dr Sharrief has anoncompensated relationship as a consultant with Abbot Laboratories that is relevant to the American Academy of Neurology interests or activities.  \nUNLABELED USE OF PRODUCTS/INVESTIGATIONAL USE DISCLOSURE:  \nDr Sharrief reports no disclosure.  \n© 2023 American Academy of Neurology.  \nCONTINUUM JOURNAL . COM 501  \nCopyright © American Academy of Neurology. Unauthorized reproduction of this article is prohibited.  \nDIAGNOSIS AND MANAGEMENT OF CEREBRAL SMALL VESSEL DISEASE  \npopulation, few specific therapies exist to decrease its progression. This article focuses on the epidemiology, clinical characteristics, and radiographic findings of CSVD and presents cases to describe its various clinical presentations.  \nEPIDEMIOLOGY AND RISK FACTORS  \nCSVD contributes to significant morbidity and mortality through its impact on stroke risk, cognitive decline, and dementia. Small vessel disease accounts for approximately 22% of ischemic stroke, and small vessel disease burden increases the risk of recurrent stroke following ischemic or hemorrhagic stroke.1–4 CSVD manifests as “silent” brain infarcts as well as clinically recognized small vessel ischemic strokes. Silent brain infarcts, which are also included in the classification of “covert cerebral small vessel disease,” are more co","cbCaim8V7Ce35uwc","https://ap.wps.com/l/cbCaim8V7Ce35uwc","pdf",2160519,1,18,"English","en",105,"# Abstract\n# Introduction\n# Epidemiology and Risk Factors\n# Diagnosis and Management\n## Latest Developments\n## Essential Points","[{\"question\":\"What makes cerebral small vessel disease clinically important?\",\"answer\":\"CSVD increases risk for ischemic and hemorrhagic stroke, contributes to silent brain infarcts, and is associated with cognitive decline and dementia.\"},{\"question\":\"How is CSVD recognized in clinical practice?\",\"answer\":\"CSVD can be identified using well-defined radiographic criteria and a range of clinical presentations.\"},{\"question\":\"What is the most established strategy to prevent stroke in CSVD?\",\"answer\":\"Hypertension control is described as the best-known strategy, with recent guidelines recommending a long-term blood pressure target of less than 130/80 mm Hg for patients with ischemic and hemorrhagic stroke, including those related to CSVD.\"}]","Diagnosis and Management of Cerebral Small Vessel Disease | PDF",1787864567,45,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"diagnosis-and-management-of-cerebral-small-vessel-disease","",{"@graph":36,"@context":85},[37,54,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/diagnosis-and-management-of-cerebral-small-vessel-disease/152607/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":62,"encodingFormat":61,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-27",true,{"@type":65,"interactionType":66,"userInteractionCount":4},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"What makes cerebral small vessel disease clinically important?","Question",{"text":75,"@type":76},"CSVD increases risk for ischemic and hemorrhagic stroke, contributes to silent brain infarcts, and is associated with cognitive decline and dementia.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"How is CSVD recognized in clinical practice?",{"text":80,"@type":76},"CSVD can be identified using well-defined radiographic criteria and a range of clinical presentations.",{"name":82,"@type":73,"acceptedAnswer":83},"What is the most established strategy to prevent stroke in CSVD?",{"text":84,"@type":76},"Hypertension control is described as the best-known strategy, with recent guidelines recommending a long-term blood pressure target of less than 130/80 mm Hg for patients with ischemic and hemorrhagic stroke, including those related to CSVD.","https://schema.org",{"og:url":52,"og:type":87,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":89,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":92},[93,97,101,105,110,115,118,123,128,131,135],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":46,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":46,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":116,"slug":117},40,"healthcare",{"id":119,"doc_module":4,"doc_module_name":46,"category_name":120,"show_sort_weight":121,"slug":122},8,"Research & Report",30,"research-report",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":46,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":132,"doc_module":4,"doc_module_name":46,"category_name":133,"show_sort_weight":132,"slug":134},10,"Lifestyle","lifestyle",{"id":136,"doc_module":4,"doc_module_name":46,"category_name":137,"show_sort_weight":106,"slug":138},19,"General","general"]