[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-379866-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-379866-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","diabetes-mellitus-induces-a-novel-inflammatory-network-involving-cancer-progression-insights-from-bioinformatic-analysis-and-in-vitro-validation","Diabetes mellitus induces a novel inflammatory network involving cancer progression - Insights from bioinformatic analysis and in vitro validation","","Diabetes mellitus is linked to a higher incidence of malignant tumors, yet the molecular mechanisms remain unclear. This study screens publicly available databases to identify diabetes and cancer-related genes and builds a diabetes-based cancer-associated inflammation network. Seven key genes are integrated and analyzed across tumor types, including drug sensitivity and single-cell sequencing in colon adenocarcinoma. In vitro experiments validate gene expression and arachidonic acid metabolic pathway activation under high-glucose stimulation.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/diabetes-mellitus-induces-a-novel-inflammatory-network-involving-cancer-progression-insights-from-bioinformatic-analysis-and-in-vitro-validation/379866/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/diabetes-mellitus-induces-a-novel-inflammatory-network-involving-cancer-progression-insights-from-bioinformatic-analysis-and-in-vitro-validation/379866.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-26","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What relationship does the study investigate between diabetes and cancer?","Question",{"text":62,"@type":63},"The study investigates how diabetes mellitus increases tumor occurrence and development by linking diabetes-related genes to cancer-associated inflammation mechanisms.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How was the diabetes-based cancer-associated inflammation network (DCIN) constructed?",{"text":67,"@type":63},"The researchers screened publicly available databases for diabetes- and cancer-related genes, integrated seven diabetes and cancer-related genes into a DCIN, and analyzed their roles across tumors.",{"name":69,"@type":60,"acceptedAnswer":70},"What experimental evidence supports the bioinformatic findings?",{"text":71,"@type":63},"In vitro experiments verified the expression of the diabetes and cancer-related genes and assessed the arachidonic acid metabolic pathway in colon adenocarcinoma epithelial cells stimulated by high glucose.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},379866,1790445679,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","TYPE Original Research PUBLISHED 23 March 2023  \nDOI 10.3389/fimmu.2023.1149810  \nOPEN ACCESS  \nEDITED BY  \nYufeng Yao,  \nHuazhong University of Science and Technology, China  \nREVIEWED BY Daniel Vegh,  \nSemmelweis University, Hungary  \nHuang Chuiguo, The Chinese University of Hong Kong, China Subhash Kumar Tripathi,  \nSeattle Children’s Research Institute, United States  \n*CORRESPONDENCE Weijun Peng  \n [pengweijun87@csu.edu.cn](pengweijun87@csu.edu.cn)  \n†These authors have contributed equally to this work  \nSPECIALTY SECTION  \nThis article was submitted to Inflammation,  \na section of the journal Frontiers in Immunology  \nRECEIVED 23 January 2023  \nACCEPTED 14 March 2023  \nPUBLISHED 23 March 2023  \nCITATION  \nTan Y, Kang J, Li H, Zhong A, Liu Y, Zhang Z, Huang R, Cheng X and Peng W (2023) Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.  \nFront. Immunol. 14:1149810 .  \ndoi: 10.3389/fimmu.2023.1149810  \nCOPYRIGHT  \n© 2023 Tan, Kang, Li, Zhong, Liu, Zhang, Huang, Cheng and Peng. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nDiabetes mellitus induces a novel inflammatory network involving cancer progression:  \nInsights from bioinformatic analysis and in vitro validation  \nYejun Tan 1,2,3†, Jin Kang 4†, Hongli Li 1,5, Aifang Zhong 6, Yaqiong Liu 7, Zheyu Zhang 1,5, Roujie Huang 8, Xin Cheng 1,5 and Weijun Peng 1,5*  \n1 Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, China, 2School of Mathematics, University of Minnesota Twin Cities, Minneapolis, MN, United States, 3 Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, United States, 4 Department of Rheumatology and Immunology, the Second Xiangya Hospital of Central South University, Changsha, China, 5 National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital,Central South University, Changsha, China, 6 Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China, 7Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland, 8 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China  \nBackground: Patients with diabetes mellitus (DM) have a higher incidence of malignant tumors than people without diabetes, but the underlying molecular mechanisms are still unclear.  \nMethods: To investigate the link between DM and cancer, we screened publicly available databases for diabetes and cancer-related genes (DCRGs) and constructed a diabetes-based cancer-associated inflammation network (DCIN) . We integrated seven DCRGs into the DCIN and analyzed their role indifferent tumors from various perspectives. We also investigated drug sensitivity and single-cell sequencing data in colon adenocarcinoma as an example. In addition, we performed in vitro experiments to verify the expression of DCRGsand the arachidonic acid metabolic pathway.  \nResults: Seven identified DCRGs, including PPARG, MMP9, CTNNB1, TNF, TGFB1, PTGS2, and HIF1A, were integrated to construct a DCIN. The bioinformatics analysis showed that the expression of the seven DCRGs in different tumors was significantly different, which had varied effects on diverse perspectives. Singlecell sequencing analyzed in colon cancer showed that the activity of the DCRGs was highest in Macrophage and the lowest in B cells","cbCaiusRTsOufLnm","https://ap.wps.com/l/cbCaiusRTsOufLnm","pdf",15577034,17,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Keywords\n# Introduction","[{\"question\":\"What relationship does the study investigate between diabetes and cancer?\",\"answer\":\"The study investigates how diabetes mellitus increases tumor occurrence and development by linking diabetes-related genes to cancer-associated inflammation mechanisms.\"},{\"question\":\"How was the diabetes-based cancer-associated inflammation network (DCIN) constructed?\",\"answer\":\"The researchers screened publicly available databases for diabetes- and cancer-related genes, integrated seven diabetes and cancer-related genes into a DCIN, and analyzed their roles across tumors.\"},{\"question\":\"What experimental evidence supports the bioinformatic findings?\",\"answer\":\"In vitro experiments verified the expression of the diabetes and cancer-related genes and assessed the arachidonic acid metabolic pathway in colon adenocarcinoma epithelial cells stimulated by high glucose.\"}]","Diabetes mellitus induces a novel inflammatory network involving cancer progression - Insights from bioinformatic analysis and in vitro validation | PDF",1790237812,43]