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Surgical stress and systemic inflammation can degrade the glycocalyx, causing endothelial dysfunction and worse postoperative outcomes. Dexmedetomidine (DEX), an α2-adrenergic agonist with anti-inflammatory and organ-protective properties, may limit glycocalyx degradation, but gastrointestinal cancer surgical evidence remains limited. This randomized, double-blind, placebo-controlled trial evaluates whether perioperative DEX attenuates inflammation-induced VEG degradation and preserves endothelial barrier function in patients undergoing gastrointestinal cancer resection.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dexmedetomidine-enhances-recovery-after-gastrointestinal-cancer-surgery-by-protecting-the-endothelial-glycocalyx-a-randomized-double-blind-placebo-controlled-study/406772/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dexmedetomidine-enhances-recovery-after-gastrointestinal-cancer-surgery-by-protecting-the-endothelial-glycocalyx-a-randomized-double-blind-placebo-controlled-study/406772.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main objective of the study?","Question",{"text":113,"@type":114},"To determine whether perioperative dexmedetomidine attenuates surgical inflammation-induced endothelial glycocalyx degradation and preserves endothelial barrier function in gastrointestinal cancer resection patients.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was dexmedetomidine administered and how was the trial designed?",{"text":118,"@type":114},"A prospective, single-center randomized, double-blind, placebo-controlled trial assigned 110 elective gastric or colorectal tumor resection patients to intraoperative DEX or saline placebo in a 1:1 ratio.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key outcomes related to endothelial glycocalyx and recovery?",{"text":122,"@type":114},"DEX reduced endothelial glycocalyx injury markers such as lower plasma syndecan-1 and heparan sulfate, improved microcirculatory parameters, and enhanced recovery outcomes including higher QoR-15 scores, shorter hospital stay, and fewer 30-day complications.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406772,1790972801,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","| W | J | G | S | World Journal of\u003Cbr>Gastrointestinal Surgery |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Surg 2025 December 27; 17(12): 114628  \nDOI: 10.4240/wjgs.v17.i12.114628 ISSN 1948-9366 (online)  \nORIGINAL ARTICLE  \nClinical Trials Study  \nDexmedetomidine enhances recovery after gastrointestinal cancer surgery by protecting the endothelial glycocalyx: A randomized, double-blind, placebo-controlled study  \nRong Zeng, Chao-Liang Tang, Yue Zhao, Rui-Xiang Wang, Yun Fang, Xian-Wen Hu  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade C  \nNovelty: Grade B, Grade C  \nCreativity or Innovation: Grade C, Grade C  \nScientific Significance: Grade B, Grade C  \nP-Reviewer: Canbaz M, MD, Türkiye  \nReceived: September 24, 2025  \nRevised: October 1, 2025  \nAccepted: November 3, 2025  \nPublished online: December 27, 2025  \nProcessing time: 92 Days and 3.2 Hours  \nRong Zeng, Xian-Wen Hu, Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China  \nRong Zeng, Yue Zhao, Rui-Xiang Wang, Yun Fang, Department of Anesthesiology, Anhui Provincial Cancer Hospital, Hefei 230031, Anhui Province, China  \nChao-Liang Tang, Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, Anhui Province, China  \nChao-Liang Tang, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, Anhui Province, China  \nXian-Wen Hu, Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230601, Anhui Province, China  \nCorresponding author: Xian-Wen Hu, PhD, Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, [China.](China. huxianwen001@163.com)[ huxianwen001@163.com](China. huxianwen001@163.com)  \nAbstract  \nBACKGROUND  \nThe vascular endothelial glycocalyx (VEG) plays a critical role in maintaining vascular barrier integrity, regulating inflammation, and ensuring microcirculatory homeostasis. Surgical stress and systemic inflammation can disrupt the glycocalyx, leading to endothelial dysfunction, impaired microcirculation, and adverse postoperative outcomes. dexmedetomidine (DEX), an α2-adrenergic agonist with anti-inflammatory and organ-protective properties, has been suggested in preclinical and clinical studies to mitigate glycocalyx degradation, yet evidence in gastrointestinal cancer surgery remains limited.  \nAIM  \nTo determine whether perioperative DEX attenuates surgical inflammation-induced VEG degradation and preserves endothelial barrier function in patients undergoing gastrointestinal cancer resection.  \n WJGS  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 27, 2025  Volume 17  Issue 12   \nZeng R et al. DEX and endothelial glycocalyx protection  \nMETHODS  \nThis was a prospective, single-center, randomized, double-blind, placebo-controlled trial conducted at the First Affiliated Hospital of University of Science and Technology of China. A total of 110 patients undergoing elective gastric or colorectal tumor resection were randomly assigned (1:1) to receive intraoperative DEX or saline placebo. Anesthesia and analgesia were standardized across groups. The primary outcome was plasma syndecan-1 concentration, a marker of endothelial glycocalyx injury, measured at four perioperative timepoints (T0-T3). Secondary outcomes included inflammatory biomarkers [interleukin-6 (IL-6), tumor necrosis factor-alpha, C-reactive protein, heparan sulfate], microcirculatory parameters [perfused vessel density (PVD)","cbCaiv0RZWQh7bx3","https://ap.wps.com/l/cbCaiv0RZWQh7bx3","pdf",1951250,15,"English","## Background\n## Aim\n## Methods\n## Results","[{\"question\":\"What is the main objective of the study?\",\"answer\":\"To determine whether perioperative dexmedetomidine attenuates surgical inflammation-induced endothelial glycocalyx degradation and preserves endothelial barrier function in gastrointestinal cancer resection patients.\"},{\"question\":\"How was dexmedetomidine administered and how was the trial designed?\",\"answer\":\"A prospective, single-center randomized, double-blind, placebo-controlled trial assigned 110 elective gastric or colorectal tumor resection patients to intraoperative DEX or saline placebo in a 1:1 ratio.\"},{\"question\":\"What were the key outcomes related to endothelial glycocalyx and recovery?\",\"answer\":\"DEX reduced endothelial glycocalyx injury markers such as lower plasma syndecan-1 and heparan sulfate, improved microcirculatory parameters, and enhanced recovery outcomes including higher QoR-15 scores, shorter hospital stay, and fewer 30-day complications.\"}]","Dexmedetomidine enhances recovery after gastrointestinal cancer surgery by protecting the endothelial glycocalyx - A randomized, double-blind, placebo-controlled study | PDF",1790567753,38]