[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-438031-en":59,"doc-seo-438031-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":72,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":80},438031,962090760730,"Mafia Boss","https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Development and Evaluation of an Innovative Inflammatory Prognostic Score for Predicting Long-Term Mortality in Patients With Pulmonary Embolism","Systemic inflammation is closely linked to adverse outcomes in acute pulmonary embolism (PE). This study developed and evaluated a novel inflammatory prognostic score (IPS) constructed from multiple inflammation-related biomarkers to predict long-term all-cause mortality. A retrospective cohort of 1642 confirmed acute PE patients was followed to January 2025. IPS derived from routine biomarkers showed independent association with mortality and improved risk stratification beyond established clinical predictors.","Wiley  \nMediators of Inflammation  \nVolume 2025, Article ID 6325915, 13 pages [https://doi.org/10.1155/mi/6325915](https://doi.org/10.1155/mi/6325915)  \nResearch Article  \nDevelopment and Evaluation of an Innovative Inflammatory Prognostic Score for Predicting Long-Term Mortality in Patients With Pulmonary Embolism  \nNing Zhu , 1,2 Lei Zhang,3 Jiabao Wu, 1 Fei Ye, 1 Nanding Yu, 1 Chao Cao,2 and Limin Chen 1  \n1Department of Respiratory and Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China 2Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China 3Department of Respiratory and Critical Care Medicine, The Affiliated People Hospital of Ningbo University, Ningbo, China  \nCorrespondence should be addressed to Limin Chen; [fzdrclm@outlook.com](fzdrclm@outlook.com)[ ](fzdrclm@outlook.com)Received 12 August 2025; Revised 19 October 2025; Accepted 27 November 2025 Academic Editor: Diogo Peruchetti  \nCopyright © 2025 Ning Zhu et al. Mediators of Inflammation published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nBackground: Systemic inflammation is closely associated with adverse outcomes in pulmonary embolism (PE) . This study aimed to develop and evaluate a novel inflammatory prognostic score (IPS) derived from multiple inflammation-related biomarkers to predict long-term all-cause mortality in patients with acute PE.  \nMethods: This retrospective cohort study included 1642 patients with confirmed acute PE admitted between January 2016 and January 2024 at the First Affiliated Hospital of Ningbo University and the Affiliated People Hospital of Ningbo University. The primary outcome was all-cause mortality. Follow-up was conducted in January 2025 . Fifteen inflammatory biomarkers were analyzed, including C-reactive protein (CRP), white blood cell count (WBC), neutrophil count (NEU), lymphocyte count (LYM), monocyte count (MON), red cell distribution width (RDW), platelet count (PLT), and eight derived indices: neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), monocyte-to-lymphocyte ratio (MLR), neutrophil–MLR (NMLR), plateletto-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and inflammatory burden index (IBI) . IPS was constructed using least absolute shrinkage and selection operator (LASSO) Cox regression. Prognostic performance was assessed using Kaplan–Meier survival analysis, multivariable Cox regression, timedependent receiver operating characteristic (ROC) analysis, and random survival forest (RSF) .  \nResults: During a median follow-up of 43.87 months, 262 patients (16.0%) died. The IPS was calculated as: IPS = 0.395 ×IBI + 0.236 ×RDW+ 0.208 ×SIRI+ 0.115 ×MLR+ 0.040 ×CRP. Patients with high IPS (≥0.55) had a significantly higher risk of allcause mortality compared to those with low IPS (adjusted hazard ratio [HR] = 2.55, 95% confidence intervals [CI]: 1.92–3.38; p \u003C 0:001) . Time-dependent area under the curve (AUC) for IPS were 0.756, 0.768, and 0.773 at 1, 3, and 5 years, respectively. When added to the baseline clinical model—including age, length of hospital stay, deep vein thrombosis, diastolic blood pressure, body mass index (BMI), lactate, log-transformed serum creatinine, blood urea nitrogen (BUN), log-transformed D-dimer, left ventricular ejection fraction (LVEF), pulmonary artery systolic pressure (PASP), and computed tomography pulmonary angiography (CTPA)-based embolism location (main pulmonary artery)—IPS improved the AUC from 0.820 to 0.886 at 3 years (p\u003C 0:001, DeLong test) . RSF analysis further identified IPS as the most informative inflammatory predictor of mortality. Conclusions: The IPS, derived from five routinely available inflammatory biomarkers, was independently associated ","cbCainuiWFkTixfb","https://ap.wps.com/l/cbCainuiWFkTixfb","pdf",786085,13,"English","en",105,"# Background\n# Methods\n## Outcomes and follow-up\n## Biomarkers and score construction\n## Statistical analyses\n# Results\n# Conclusions","[{\"question\":\"What was the purpose of the study on PE outcomes?\",\"answer\":\"To develop and evaluate an inflammatory prognostic score (IPS) that predicts long-term all-cause mortality in patients with acute pulmonary embolism.\"},{\"question\":\"How was the IPS constructed in the study?\",\"answer\":\"The IPS was built using LASSO Cox regression based on 15 inflammatory biomarkers and several derived inflammation indices, with the final formula using five routinely available markers.\"},{\"question\":\"Did the IPS improve prediction beyond existing clinical factors?\",\"answer\":\"Yes. Adding IPS to a baseline clinical model increased the time-dependent AUC (notably at 3 years) and enhanced risk stratification for all-cause mortality.\"}]","Development and Evaluation of an Innovative Inflammatory Prognostic Score for Predicting Long-Term Mortality in Patients With Pulmonary Embolism | PDF",1790683949,33,{"code":4,"msg":82,"data":83},"ok",{"site_id":75,"language":74,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":139,"head_meta":141,"extra_data":143,"updated_unix":79},"development-and-evaluation-of-an-innovative-inflammatory-prognostic-score-for-predicting-long-term-mortality-in-patients-with-pulmonary-embolism","",{"@graph":87,"@context":138},[88,102,121],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,100],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":40,"@type":94,"position":99},"https://docshare.wps.com/document/research-report/",3,{"item":101,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/development-and-evaluation-of-an-innovative-inflammatory-prognostic-score-for-predicting-long-term-mortality-in-patients-with-pulmonary-embolism/438031/",{"url":101,"name":65,"@type":103,"image":104,"author":109,"headline":65,"publisher":111,"fileFormat":114,"inLanguage":74,"description":66,"dateModified":115,"datePublished":115,"encodingFormat":114,"isAccessibleForFree":116,"interactionStatistic":117},"DigitalDocument",{"url":105,"@type":106,"width":107,"height":108},"https://docshare.wps.com/thumbnails/development-and-evaluation-of-an-innovative-inflammatory-prognostic-score-for-predicting-long-term-mortality-in-patients-with-pulmonary-embolism/438031.png","ImageObject",300,407,{"name":63,"@type":110},"Person",{"url":92,"name":112,"@type":113},"DocShare","Organization","application/pdf","2026-09-29",true,{"@type":118,"interactionType":119,"userInteractionCount":4},"InteractionCounter",{"@type":120},"ViewAction",{"@type":122,"mainEntity":123},"FAQPage",[124,130,134],{"name":125,"@type":126,"acceptedAnswer":127},"What was the purpose of the study on PE outcomes?","Question",{"text":128,"@type":129},"To develop and evaluate an inflammatory prognostic score (IPS) that predicts long-term all-cause mortality in patients with acute pulmonary embolism.","Answer",{"name":131,"@type":126,"acceptedAnswer":132},"How was the IPS constructed in the study?",{"text":133,"@type":129},"The IPS was built using LASSO Cox regression based on 15 inflammatory biomarkers and several derived inflammation indices, with the final formula using five routinely available markers.",{"name":135,"@type":126,"acceptedAnswer":136},"Did the IPS improve prediction beyond existing clinical factors?",{"text":137,"@type":129},"Yes. Adding IPS to a baseline clinical model increased the time-dependent AUC (notably at 3 years) and enhanced risk stratification for all-cause mortality.","https://schema.org",{"og:url":101,"og:type":140,"og:title":65,"og:site_name":112,"og:description":66},"article",{"robots":142,"canonical":101},"index,follow",{"doc_id":61,"site_id":75}]