[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-368880-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-368880-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","deubiquitinating-enzyme-otuds-focus-on-cancers-and-antiviral-response-review","Deubiquitinating Enzyme OTUDs - Focus on Cancers and Antiviral Response - Review","","Deubiquitinating enzymes (DUBs) cleave ubiquitin chains and cooperate with ubiquitination modifications to regulate key protein functions while maintaining normal physiology. OTUDs are an important OTU-family DUB subfamily, including OTUD1, OTUD2, OTUD3, OTUD4, OTUD5, OTUD6A, and OTUD6B. Their aberrant expression is linked to cancers, immune abnormalities, neurological disorders, and developmental defects. This review details individual OTUD roles in cancer progression and antiviral response, summarizes deubiquitinated targets and signaling mechanisms, and discusses therapeutic targeting, while noting limited inhibitor/activator studies and the need to assess antiviral immune effects.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/deubiquitinating-enzyme-otuds-focus-on-cancers-and-antiviral-response-review/368880/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/deubiquitinating-enzyme-otuds-focus-on-cancers-and-antiviral-response-review/368880.png","ImageObject",300,407,{"name":42,"@type":43},"Mary Man","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What are deubiquitinating enzymes (DUBs) and why are they important?","Question",{"text":63,"@type":64},"DUBs can cleave ubiquitin chains and cooperate with ubiquitination modifications. They help regulate the function of key proteins and maintain normal physiological functions.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which OTUD proteins are covered as the OTUDs subfamily?",{"text":68,"@type":64},"The review highlights OTUD1, OTUD2, OTUD3, OTUD4, OTUD5, OTUD6A, and OTUD6B as major OTUDs members.",{"name":70,"@type":61,"acceptedAnswer":71},"How do OTUDs relate to cancer progression and antiviral response?",{"text":72,"@type":64},"In cancer, OTUDs are discussed through their deubiquitinated protein targets and the signaling mechanisms that promote or inhibit progression. The review also emphasizes that OTUD targeting should consider effects on the host’s antiviral immune response.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},368880,1790471144,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":99},7421720224475,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Tech Science Press  \nDoi:10.32604/or.2025.063644  \nREVIEW  \nDeubiquitinating Enzyme OTUDs: Focus on Cancers and Antiviral Response Lang Chen1, Rui Dong1 and Xuan Huan2, *  \n1 Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China 2 Department of Geriatric Medicine, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China  \n*[Corresponding Author: Xuan Huan. Email: huanxuan0612@163.com](Corresponding Author: Xuan Huan. Email: huanxuan0612@163.com)  \n[Received: 20 January 2025](Received: 20 January 2025); [Accepted: 27 June 2025](Accepted: 27 June 2025); [Published: 26 September 2025](Published: 26 September 2025)  \nABSTRACT: Deubiquitinating enzymes (DUBs) are key enzymes capable ofcleaving ubiquitin chains and synergizing with ubiquitination modifications to regulate the function of key proteins and maintain normal physiological functions. OTUDs are a key subfamily of the ovarian tumor protease (OTU) family, with important DUB activities, and include mainly OTUD1, OTUD2, OTUD3, OTUD4, OTUD5, OTUD6A, and OTUD6B. In recent years, research on OTUD proteins has been gradually emphasized, and their aberrant expression has demonstrated significant research value in many diseases, such as cancer, immune abnormalities, neurological disorders, and embryonic developmental abnormalities. Therefore, a comprehensive understanding of the regulatory mechanisms of OTUD proteins and their use as therapeutic targets for diseases is of great value. This article focuses on the role of individual OTUD proteins in cancer progression and antiviral response. Importantly, in the context of cancer, we elaborate on their deubiquitinated protein targets and summarize the signaling mechanisms by which they promote or inhibit cancer progression. In the future, targeting OTUD proteins may become a therapeutic direction for cancer, and this review may be useful for research related to OTUD proteins and cancer. At present, there is a lack of research on targeted inhibitors or activators of OTUDs. More in vivo and in vitro studies on OTUDs may contribute to the development of inhibitors or agonists targeting OTUDs. Of course, when conducting these studies, researchers also need to pay attention to the impact of OTUDs on the host’s antiviral immune response.  \nKEYWORDS: Deubiquitinating enzymes (DUBs); OTUDs; cancer; antiviral response  \n1 Introduction to Ubiquitination  \nThe ubiquitin-proteasome system (UPS) is a key pathway that regulates the degradation of proteins that undergo misfolding and oxidative damage in eukaryotic cells, including ubiquitination of proteins and degradation of proteasomes [1] . Ubiquitin (Ub) is a polypeptide with 76 amino acids highly conserved in eukaryotes. Ubiquitination of proteins is the process by which the C-terminal glycine residue of Ub is covalently linked to a lysine residue in the substrate protein [2] . This process belongs to an ATP-dependent post-translational modification, which plays a key role in regulating signaling, cell cycle, apoptosis, protein translocation, and DNA damage repair [3] . Ubiquitination is tightly controlled by the so-called three-step enzyme-catalyzed process, including ubiquitin-activating enzymes (E1), ubiquitin-coupling enzymes (E2), and ubiquitin ligases (E3), whose sequential modification of the substrate proteins determines the final function of the protein [4]. Driven by ATP, the cysteine residue on E1 forms a high-energy thioester bond with Ub; then E1 transfers Ub to the cysteine residue on E2; finally, E3 assists E2 in recognizing target proteins and transfers E2-bound Ub to the lysine residue of a specific target protein, and this is repeated until a complete Ub chain is formed [1,2] .  \nCopyright © 2025 The Authors. Published by Tech Science Press.  \nThis work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provid","cbCaiuCXO3uvZ7jw","https://ap.wps.com/l/cbCaiuCXO3uvZ7jw","pdf",6658830,24,"English","# Introduction to Ubiquitination\n# Members of the OTUDs Subfamily of Deubiquitinating Enzymes","[{\"question\":\"What are deubiquitinating enzymes (DUBs) and why are they important?\",\"answer\":\"DUBs can cleave ubiquitin chains and cooperate with ubiquitination modifications. They help regulate the function of key proteins and maintain normal physiological functions.\"},{\"question\":\"Which OTUD proteins are covered as the OTUDs subfamily?\",\"answer\":\"The review highlights OTUD1, OTUD2, OTUD3, OTUD4, OTUD5, OTUD6A, and OTUD6B as major OTUDs members.\"},{\"question\":\"How do OTUDs relate to cancer progression and antiviral response?\",\"answer\":\"In cancer, OTUDs are discussed through their deubiquitinated protein targets and the signaling mechanisms that promote or inhibit progression. The review also emphasizes that OTUD targeting should consider effects on the host’s antiviral immune response.\"}]","Deubiquitinating Enzyme OTUDs - Focus on Cancers and Antiviral Response - Review | PDF",1790179065]