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This observational study evaluates Raman spectroscopy for identifying cancer in unstained, formalin-fixed, resected esophagus and stomach specimens. Raman-scattered light spectra are acquired from endoscopically resected tissues, linked to histological differences in mucosal structures. Data analysis at the molecular level establishes diagnostic cut-off values and an algorithm to classify esophageal squamous cell carcinoma and gastric adenocarcinoma with accuracy comparable to histopathology.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/determination-of-esophageal-squamous-cell-carcinoma-and-gastric-adenocarcinoma-on-raw-tissue-using-raman-spectroscopy/381267/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/determination-of-esophageal-squamous-cell-carcinoma-and-gastric-adenocarcinoma-on-raw-tissue-using-raman-spectroscopy/381267.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What technique is used to detect cancer in the study?","Question",{"text":113,"@type":114},"Raman spectroscopy is used to record Raman-scattered light spectra from unstained formalin-fixed esophageal and gastric specimens.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What specimens and sampling strategy are evaluated?",{"text":118,"@type":114},"Raman spectra are acquired from endoscopically resected specimens including six esophageal tissues and 12 gastric tissues, with shifts measured at multiple locations separated by 200 microns.",{"name":120,"@type":111,"acceptedAnswer":121},"How are diagnostic cut-off values and classification performed?",{"text":122,"@type":114},"Molecular-level analysis of the Raman spectra is used to establish cut-off values for esophageal squamous cell carcinoma and gastric adenocarcinoma, followed by an algorithm that matches histopathological diagnoses closely.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},381267,1790271509,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2023 May 28; 29(20): 3145-3156  \nDOI: 10.3748/wjg.v29.i20.3145 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nObservational Study  \nDetermination of esophageal squamous cell carcinoma and gastric adenocarcinoma on raw tissue using Raman spectroscopy  \nHiroaki Ito, Naoyuki Uragami, Tomokazu Miyazaki, Yuto Shimamura, Haruo Ikeda, Yohei Nishikawa, Manabu Onimaru, Kai Matsuo, Masayuki Isozaki, William Yang, Kenji Issha, Satoshi Kimura, Machiko Kawamura, Noboru Yokoyama, Miki Kushima, Haruhiro Inoue  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): 0  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Gao SG, China  \nReceived: December 12, 2022  \nPeer-review started: December 12, 2022  \nFirst decision: March 9, 2023  \nRevised: April 10, 2023  \nAccepted: April 27, 2023  \nArticle in press: April 27, 2023  \nPublished online: May 28, 2023  \nHiroaki Ito, Naoyuki Uragami, Yuto Shimamura, Haruo Ikeda, Yohei Nishikawa, Manabu Onimaru, Kai Matsuo, Masayuki Isozaki, Noboru Yokoyama, Haruhiro Inoue, Digestive Disease Center,  \nShowa University Koto Toyosu Hospital, Tokyo 135-8577, Japan Tomokazu Miyazaki, JSR Corporation, Tokyo 105-0021, Japan William Yang, Bay Spec Inc., San Jose, CA 95131, United States Kenji Issha, Fuji Technical Research Inc., Yokohama 220-6215, Japan  \nSatoshi Kimura, Department of Laboratory Medicine and Central Clinical Laboratory, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan  \nMachiko Kawamura, Department of Hematology, Saitama Cancer Center, Inamachi 362-0806, Japan  \nMiki Kushima, Department of Pathology, Showa University Koto Toyosu Hospital, Tokyo 135- 8577, Japan  \nCorresponding author: Hiroaki Ito, MD, PhD, Associate Professor, Digestive Disease Center, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu, Koto-ku, Tokyo 135-8577, Japan.  \n[h.ito@med.showa-u.ac.jp](h.ito@med.showa-u.ac.jp)  \nAbstract  \nBACKGROUND  \nCancer detection is a global research focus, and novel, rapid, and label-free techniques are being developed for routine clinical practice. This has led to the development of new tools and techniques from the bench side to routine clinical practice. In this study, we present a method that uses Raman spectroscopy (RS) to detect cancer in unstained formalin-fixed, resected specimens of the esophagus and stomach. Our method can record a clear Raman-scattered light spectrum in these specimens, confirming that the Raman-scattered light spectrum changes because of the histological differences in the mucosal tissue.  \nAIM  \nTo evaluate the use of Raman-scattered light spectrum for detecting endoscop-  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 3145 May 28, 2023  Volume 29  Issue 20   \nIto H et al. Detecting SCC and AC using RS  \nically resected specimens of esophageal squamous cell carcinoma (SCC) and gastric adenocarcinoma (AC) .  \nMETHODS  \nWe created a Raman device that is suitable for observing living tissues, and attempted to acquire Raman-scattered light spectra in endoscopically resected specimens of six esophageal tissues and  \n12 gastric tissues. We evaluated formalin-fixed tissues using this technique and captured shifts at multiple locations based on feasibility, ranging from six to 19 locations 200 microns apart in the vertical and horizontal directions. Furthermore, a correlation between the obtained Raman scattered light spectra and histopathological diagnosis was performed.  \nRESULTS  \nWe successfully obtained Raman scattered light spectra from all six esophageal and 12 gastric specimens. After data capture, the tissue spec","cbCaindwzYEEh0Yi","https://ap.wps.com/l/cbCaindwzYEEh0Yi","pdf",16815141,13,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip\n# Citation","[{\"question\":\"What technique is used to detect cancer in the study?\",\"answer\":\"Raman spectroscopy is used to record Raman-scattered light spectra from unstained formalin-fixed esophageal and gastric specimens.\"},{\"question\":\"What specimens and sampling strategy are evaluated?\",\"answer\":\"Raman spectra are acquired from endoscopically resected specimens including six esophageal tissues and 12 gastric tissues, with shifts measured at multiple locations separated by 200 microns.\"},{\"question\":\"How are diagnostic cut-off values and classification performed?\",\"answer\":\"Molecular-level analysis of the Raman spectra is used to establish cut-off values for esophageal squamous cell carcinoma and gastric adenocarcinoma, followed by an algorithm that matches histopathological diagnoses closely.\"}]","Determination of esophageal squamous cell carcinoma and gastric adenocarcinoma on raw tissue using Raman spectroscopy | PDF",1790244536,33]