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In Sri Lanka, many central nervous system infections occur annually, yet etiological diagnosis remains unknown for most suspected cases because multiple arboviruses are endemic or sporadically reported. This retrospective study aimed to identify dengue virus infections in clinically suspected encephalitis patients in the central region and evaluate detection by molecular and serological methods.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/detection-of-dengue-virus-encephalitis-in-central-part-of-sri-lanka/406801/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/detection-of-dengue-virus-encephalitis-in-central-part-of-sri-lanka/406801.png","ImageObject",300,407,{"name":92,"@type":93},"Anna Hans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"Why do the results matter for future public health practice?","Question",{"text":112,"@type":113},"The findings support the presence of DENV-associated central nervous system infections and indicate the need for broader surveillance and more advanced diagnostic approaches in the future.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},406801,1790918516,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":131,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":132,"faqs":133,"seo_title":134,"seo_description":67,"update_tm":135,"read_time":136,"preview_page_count":4},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","| W | J | V | World Journal of\u003Cbr>Virology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Virol 2025 December 25; 14(4): 115071  \nDOI: 10.5501/wjv.v14.i4.115071 ISSN 2220-3249 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nDetection of dengue virus encephalitis in central part of Sri Lanka  \nInuri Perera, Achini Weerathunga, Nipuni Arachchige, Lakmali Rajamanthri, Sachini Fernando, Rohitha Muthugala  \nSpecialty type: Virology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade C  \nCreativity or Innovation: Grade C  \nScientific Significance: Grade B  \nP-Reviewer: Kalinina OV, Professor, Russia  \nReceived: October 13, 2025  \nRevised: November 19, 2025  \nAccepted: December 11, 2025  \nPublished online: December 25, 2025  \nProcessing time: 79 Days and 14.7 Hours  \nInuri Perera, Sachini Fernando, Centre for Biotechnology, Department of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda 10250, Western, Sri Lanka  \nAchini Weerathunga, Nipuni Arachchige, Rohitha Muthugala, Department of Molecular Biology, Medical Research Institute, Colombo 00800, Western, Sri Lanka  \nLakmali Rajamanthri, Rohitha Muthugala, Department of Virology, National Hospital Kandy, Kandy 20000, Sri Lanka  \nCorresponding author: Rohitha Muthugala, MD, Consultant, Department of Molecular Biology, Medical Research Institute, No. 527 Dr. Danister De Silva Mawatha, Colombo 00800, Western, [Sri Lanka.](Sri Lanka. rohithavm@yahoo.com)[ rohithavm@yahoo.com](Sri Lanka. rohithavm@yahoo.com)  \nAbstract  \nBACKGROUND  \nIn tropical Asia, arbovirus-induced encephalitis continues to be a serious public health issue. Encephalitis is caused by wide range of neurotropic pathogens, and flaviviruses are one of the main causative agents in the area. Sri Lanka reports a considerable number of central nervous system infections annually. Both dengue and Japanese encephalitis are endemic, and cases of Zika and West Nile virus infections were reported occasionally in Sri Lanka. Although reported number of Japanese encephalitis cases has reduced in the past, aetiological diagnosis in majority of encephalitis cases is still unknown.  \nAIM  \nTo detect dengue virus (DENV) infections in individuals in the central region of Sri Lanka who were clinically suspected of having encephalitis.  \nMETHODS  \nA retrospective observational analysis was conducted on 99 cerebrospinal fluid samples received to a virology laboratory from patients in the central part of Sri Lanka who were clinically suspected of having encephalitis. Samples were analyzed using reverse transcriptase polymerase chain reaction (RT-PCR) with universal flavivirus primers to detect flaviviral RNA followed by DENV serotyping real-time RT-PCR, and an immunoglobulin M (IgM) detection enzyme-linked immunosorbent assay to detect IgM antibodies indicative of a possible recent DENV infection.  \n WJV  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 25, 2025  Volume 14  Issue 4   \nPerera I et al. DENV encephalitis in Sri Lanka  \nRESULTS  \nDENV aetiology was detected in 6 (6.06%) cerebrospinal fluid samples, and all were confirmed as DENV infections. A single positive result (1.01%) was yielded through RT-PCR and was identified as DENV serotype 3. Serology testing detected 05 (5.05%) anti-dengue IgM positives and further investigation indicated probable DENVaetiology. Among positives 02 (33.33%) were children (aged less than 14 years), and rest were adults.  \nCONCLUSION  \nThese findings underscore the presence of DENV-associated central nervous system infections and highlight the need for broader surveillance and more advanced diagnostic approaches in the future.  \nKey Words: Flavivirus; Central nervous system infections; Neurotropic viruses; Dengue; Sri Lanka  \n©The Author(s) 2025. Publi","cbCaigljHMjY7rO5","https://ap.wps.com/l/cbCaigljHMjY7rO5","pdf",2481943,"English","# Background\n# Aim\n# Methods\n# Results\n# Conclusion\n# Key words","[{\"question\":\"Why do the results matter for future public health practice?\",\"answer\":\"The findings support the presence of DENV-associated central nervous system infections and indicate the need for broader surveillance and more advanced diagnostic approaches in the future.\"}]","Detection of dengue virus encephalitis in central part of Sri Lanka | PDF",1790567943,25]