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Conventional agents like calcium hydroxide and mineral trioxide aggregate are established, but increasing attention is directed to bioactive dentin-derived autografts and xenografts. This review assessed five experimental studies across rat, canine, swine, and human models, evaluating regenerative outcomes of demineralized bone matrix, treated dentin matrix hydrogel, xenogeneic demineralized dentin paste, and autologous demineralized dentin matrix.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dentin-autograft-as-a-pulp-capping-material-a-systematic-review/460226/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dentin-autograft-as-a-pulp-capping-material-a-systematic-review/460226.png","ImageObject",300,407,{"name":92,"@type":93},"pop out","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the goal of vital pulp therapy in this review?","Question",{"text":112,"@type":113},"Vital pulp therapy aims to preserve and maintain the vitality and function of the dental pulp after exposure from caries, trauma, or iatrogenic causes, largely by stimulating reparative dentinogenesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which dental pulp capping materials are compared or evaluated?",{"text":117,"@type":113},"The review discusses conventional options such as calcium hydroxide and mineral trioxide aggregate, and evaluates dentin-derived alternatives including demineralized bone matrix, treated dentin matrix hydrogel, xenogeneic demineralized dentin paste, and autologous demineralized dentin matrix.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes were examined across the included studies?",{"text":121,"@type":113},"Key outcomes include inflammatory response, pulp tissue organization, dentin bridge formation, odontogenic marker expression, biodegradation characteristics, and the quality of regenerated dentin.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},460226,1790758049,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":39,"preview_page_count":4},962090760408,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Systematic Review  \nDentin Autograft as a Pulp Capping Material: A Systematic Review  \nWasifoddin A. Chaudhari1, Sameer K. Jadhav2, Manu Bansal1, Shweta Jadhav3, Surajsinh U. Chouhan3, Shweta Bhayde4  \n1Department of Conservative Dentistry and Endodontics, Jaipur Dental College, Jaipur, Rajasthan, India, 2Department of Conservative Dentistry and Endodontics, M.A. Rangoonwala  \nCollege of Dental Science and Research Centre,  \nPune, Maharashtra, India, 3Department of Conservative Dentistry and Endodontics, Saraswati Dhanwantari Dental College and Hospital, Parbhani, Maharashtra, India, 4Department of Conservative Dentistry and Endodontics, Nanded Rural Dental College and Hospital, Nanded, Maharashtra, India  \nSubmitted: 20‑Aug‑2025  \nRevised: 25‑Aug‑2025  \nAccepted: 31‑Aug‑2025  \nPublished: 17‑Dec‑2025  \nAbstract  \nVital pulp therapy focuses on maintaining pulp vitality and stimulating reparative dentinogenesis following pulp exposure. While conventional materials such as calcium hydroxide and mineral trioxide aggregate remain established options, there is growing interest in bioactive autograft and xenograft dentin‑derived materials. This review evaluated five experimental studies across rat, canine, swine, and human models assessing the regenerative performance of demineralized bone matrix, treated dentin matrix hydrogel, xenogeneic demineralized dentin paste, and autologous demineralized dentin matrix. Key outcomes examined included inflammatory response, pulp tissue organization, dentin bridge formation, odontogenic marker expression, biodegradation characteristics, and the quality of regenerated dentin. All studies demonstrated preservation of pulp vitality and clear evidence of reparative dentin formation. Demineralized bone matrix induced organized dentinogenesis with reduced inflammation compared to calcium hydroxide. Treated dentin matrix hydrogel produced complete, thick dentin bridges with well‑aligned odontoblast layers and biodegradation synchronized with new dentin deposition. Xenogeneic dentin paste formed physiologic dentin bridges within 4–8 weeks in canine models, closely mimicking natural dentin structure. Autologous dentin matrix in swine supported high‑quality reparative dentin comparable to or better than Bioglass® and calcium hydroxide. Across studies, dentin‑derived materials showed favorable biocompatibility, minimal inflammation, and strong inductive potential. These findings highlight their promise as regenerative alternatives to conventional pulp capping agents, though further standardized clinical trials are required to validate long-term effectiveness.  \nKeywords: Demineralized dentin, dentin autograft, direct pulp capping, treated dentin matrix, vital pulp therapy   \nIntroduction  \nVital pulp therapy (VPT) aims to preserve and  \nmaintain the vitality and function of the dental pulp following exposure due to caries, trauma, or iatrogenic causes. A critical aspect of VPT is the selection of a pulp capping material that can both protect the exposed pulp and stimulate reparative dentinogenesis.[1,2]  \nHistorically, calcium hydroxide (Ca(OH)2) has been the benchmark pulp capping agent due to its antibacterial activity and ability to stimulate dentin bridge formation. However, limitations include tunnel defects in the dentin bridge, poor sealing ability, and long‑term solubility. Mineral trioxide aggregate (MTA) has addressed many of these limitations, showing improved sealing and more  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website: [https://journals.lww.com/jpbs](https://journals.lww.com/jpbs) |\n|  | DOI: 10.4103/jpbs.jpbs_1471_25 |\n\nconsistent dentin bridge quality, but is hindered by long setting times, discoloration potential, and high cost.[3,4]  \nRecently, there has been growing interest in biologically derived materials, especially dentin autograft and related derivatives such as demineralized dentin matrix (DDM), treated dentin matrix hydrogel (TDMH), and x","cbCaifOJWgednVWr","https://ap.wps.com/l/cbCaifOJWgednVWr","pdf",518916,"English","# Abstract\n# Introduction\n# Methods","[{\"question\":\"What is the goal of vital pulp therapy in this review?\",\"answer\":\"Vital pulp therapy aims to preserve and maintain the vitality and function of the dental pulp after exposure from caries, trauma, or iatrogenic causes, largely by stimulating reparative dentinogenesis.\"},{\"question\":\"Which dental pulp capping materials are compared or evaluated?\",\"answer\":\"The review discusses conventional options such as calcium hydroxide and mineral trioxide aggregate, and evaluates dentin-derived alternatives including demineralized bone matrix, treated dentin matrix hydrogel, xenogeneic demineralized dentin paste, and autologous demineralized dentin matrix.\"},{\"question\":\"What outcomes were examined across the included studies?\",\"answer\":\"Key outcomes include inflammatory response, pulp tissue organization, dentin bridge formation, odontogenic marker expression, biodegradation characteristics, and the quality of regenerated dentin.\"}]","Dentin Autograft as a Pulp Capping Material - A Systematic Review | PDF"]