[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-32161":3,"doc-seo-32161":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},32161,4398048950312,"Violet","https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908",8,"Research & Report","Dengue and Severe Dengue — Virology Review","A virology review focused on dengue virus (DENV) and severe dengue, organizing current knowledge from infection biology to clinical and public-health challenges. The document surveys DENV-host interactions, viral genetics, antibody-enhanced infection, immunopathogenesis, and host susceptibility factors that shape progression to severe disease. It also examines changing dengue epidemiology and discusses evolving case-management needs across older adults, pregnancy, and immunosuppressed patients, followed by a section on dengue therapeutics including antiviral development.","cbCaifqUg5i2TfBI","https://ap.wps.com/l/cbCaifqUg5i2TfBI","pdf",4658147,1,44,"English","en","# SUMMARY\n# INTRODUCTION\n# DENV AND DENV INFECTION\n## UPDATES ON DENGUE PATHOGENESIS\n## CHANGING DENGUE EPIDEMIOLOGY\n## NEW CASE MANAGEMENT CHALLENGES\n## DENGUE THERAPEUTICS","[{\"question\":\"What aspects of dengue progression are covered in the review?\",\"answer\":\"The review covers dengue infection and updates on dengue pathogenesis, including DENV-host interactions, antibody-enhanced infection, immunopathogenesis, and host susceptibility factors for severe dengue.\"},{\"question\":\"How does the document address epidemiology?\",\"answer\":\"It reviews changing dengue epidemiology, including the worsening global dengue burden, dengue in travelers, and changing population structure in endemic regions.\"},{\"question\":\"Which patient groups and treatment directions are discussed?\",\"answer\":\"Case-management challenges are discussed for older adults, pregnancy, and immunosuppressed individuals. The therapeutics section includes antiviral drug discovery and development, emphasizing direct-acting antiviral drug approaches.\"}]",1780952497,111,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"dengue-and-severe-dengue-virology-review","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/dengue-and-severe-dengue-virology-review/32161/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-06-08",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What aspects of dengue progression are covered in the review?","Question",{"text":73,"@type":74},"The review covers dengue infection and updates on dengue pathogenesis, including DENV-host interactions, antibody-enhanced infection, immunopathogenesis, and host susceptibility factors for severe dengue.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How does the document address epidemiology?",{"text":78,"@type":74},"It reviews changing dengue epidemiology, including the worsening global dengue burden, dengue in travelers, and changing population structure in endemic regions.",{"name":80,"@type":71,"acceptedAnswer":81},"Which patient groups and treatment directions are discussed?",{"text":82,"@type":74},"Case-management challenges are discussed for older adults, pregnancy, and immunosuppressed individuals. The therapeutics section includes antiviral drug discovery and development, emphasizing direct-acting antiviral drug approaches.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]