[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330515-105":59,"doc-detail-330515-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","dendritic-pyridineimine-copper-complexes-as-metallo-drugs","Dendritic Pyridine–Imine Copper Complexes as Metallo-Drugs","","Since the discovery of cisplatin in the 1960s, the search for metallo-drugs more effective than platinum complexes with minimal side effects has driven extensive work in anticancer chemistry. Copper has gained renewed attention due to cuproptosis, a copper-mediated form of cell death, yet copper can also promote cancer cell proliferation. This review analyzes copper chelators, emphasizing Schiff base derivatives and pyridine–imine motifs, and explains how dendrimer-linked complexes may support improved therapy and diagnosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dendritic-pyridineimine-copper-complexes-as-metallo-drugs/330515/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dendritic-pyridineimine-copper-complexes-as-metallo-drugs/330515.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is copper considered both promising and problematic for anticancer metallo-drugs?","Question",{"text":112,"@type":113},"Copper is highlighted by the recently evidenced phenomenon of cuproptosis, which is mediated by copper and may support cancer treatment. However, copper can also stimulate proliferation and migration of cells involved in tumor angiogenesis, and it may increase serum copper levels as cancer progresses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What copper-chelation strategy does the review emphasize?",{"text":117,"@type":113},"The review emphasizes Schiff-based derivatives, particularly a pyridine–imine Schiff base motif, as copper chelators with wide chemical possibilities for biomedical applications.",{"name":119,"@type":110,"acceptedAnswer":120},"How do dendrimer-based architectures relate to improved drug delivery?",{"text":121,"@type":113},"The review explains that assembling metal complexes into larger nanoscale entities can enhance properties. It links dendrimer systems to the EPR (enhanced permeability and retention) effect, which supports more targeted delivery to solid tumors, and positions dendrimers as candidates for improved therapy and diagnosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330515,1790184104,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","molecules   \nReview  \nDendritic Pyridine–Imine Copper Complexes as Metallo-Drugs  \nRégis Laurent 1,2, Valérie Maraval 1,2, Vania Bernardes-Génisson 1,2 and Anne-Marie Caminade 1,2, *  \nCitation: Laurent, R.; Maraval, V.; Bernardes-Génisson, V.; Caminade, A.-M. Dendritic Pyridine–Imine Copper Complexes as Metallo-Drugs. Molecules 2024, 29, 1800. [https://](https://)[ ](https://)[doi.org/10.3390/molecules29081800](doi.org/10.3390/molecules29081800)  \nAcademic Editors: Ashok Kakkar and Maura Pellei  \nReceived: 28 March 2024  \nRevised: 6 April 2024  \nAccepted: 12 April 2024  \nPublished: 16 April 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, BP 44099,  \n31077 Toulouse, CEDEX 4, France; [regis.laurent@lcc-toulouse.fr](regis.laurent@lcc-toulouse.fr) (R.L.); [valerie.maraval@lcc-toulouse.fr](valerie.maraval@lcc-toulouse.fr) (V.M.); [vania.bernardes-genisson@lcc-toulouse.fr](vania.bernardes-genisson@lcc-toulouse.fr) (V.B.-G.)  \n2 LCC-CNRS, Université de Toulouse, CNRS, 31077 Toulouse, France  \n* Correspondence: [anne-marie.caminade@lcc-toulouse.fr](anne-marie.caminade@lcc-toulouse.fr)  \nAbstract: Since the discovery of cisplatin in the 1960s, the search for metallo-drugs that are more efficient than platinum complexes with negligible side effects has attracted much interest. Among the other metals that have been examined for potential applications as anticancer agents is copper. The interest in copper was recently boosted by the discovery of cuproptosis, a recently evidenced form of cell death mediated by copper. However, copper is also known to induce the proliferation of cancer cells. In view of these contradictory results, there is a need to find the most suitable copper chelators, among which Schiff-based derivatives offer a wide range of possibilities. Gathering several metal complexes in a single, larger entity may provide enhanced properties. Among the nanometric objects suitable for such purpose are dendrimers, precisely engineered hyperbranched macromolecules, which are outstanding candidates for improving therapy and diagnosis. In this review article, we present an overview of the use of a particular Schiff base, namely pyridine–imine, linked to the surface of dendrimers, suitable for complexing copper, and the use of such dendrimer complexes in biology, in particular against cancers.  \nKeywords: dendrimer; Schiff base; pyridine–imine; copper; metallo-drugs; cancer; phosphorus; carbosilane; PAMAM  \n1. Introduction  \nSince the discovery of cisplatin in the 1960s and the success of its use to treat cancers [1], researchers in bioinorganic chemistry have first focused on platinum derivatives, which are of current use to treat testicular, ovarian, and lung cancers [2] . The search for metallo-drugs more efficient than platinum complexes, while having negligible side effects, has attracted much interest, as recently emphasized in a review of in vivo studies of the anticancer activities of metal complexes [3] . Among the metals that have been thoroughly examined for potential applications as anticancer agents are mainly ruthenium, titanium, gold, and copper. Some of the corresponding complexes have been designed for clinical trials [4,5] . The use of copper complexes as anticancer agents has been reviewed early [6] in an article structured according to the type of ligands used to complex copper [7] . The interest in copper was boosted in the last few years, on the one hand, by the hypothesis that an endogenous metal might exhibit fewer adverse effects on the body than exogenous metals, such as platinum, and on the other hand, by the discovery of ","cbCaiesYCrMPnWc7","https://ap.wps.com/l/cbCaiesYCrMPnWc7","pdf",5758284,18,"English","# Abstract\n# Introduction\n## Cisplatin and platinum-based metallo-drugs\n## Copper as an anticancer candidate\n## Cuproptosis and contradictory copper effects\n## Need for suitable copper chelators\n## Schiff-based copper chelators\n# Dendrimers and complex architectures\n## EPR effect and targeted delivery\n## Dendrimer rationale for therapy and diagnosis","[{\"question\":\"Why is copper considered both promising and problematic for anticancer metallo-drugs?\",\"answer\":\"Copper is highlighted by the recently evidenced phenomenon of cuproptosis, which is mediated by copper and may support cancer treatment. However, copper can also stimulate proliferation and migration of cells involved in tumor angiogenesis, and it may increase serum copper levels as cancer progresses.\"},{\"question\":\"What copper-chelation strategy does the review emphasize?\",\"answer\":\"The review emphasizes Schiff-based derivatives, particularly a pyridine–imine Schiff base motif, as copper chelators with wide chemical possibilities for biomedical applications.\"},{\"question\":\"How do dendrimer-based architectures relate to improved drug delivery?\",\"answer\":\"The review explains that assembling metal complexes into larger nanoscale entities can enhance properties. It links dendrimer systems to the EPR (enhanced permeability and retention) effect, which supports more targeted delivery to solid tumors, and positions dendrimers as candidates for improved therapy and diagnosis.\"}]","Dendritic Pyridine–Imine Copper Complexes as Metallo-Drugs | PDF",1789989253,45]