[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-454014-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-454014-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","demystifying-anti-inflammatory-therapeutic-strategies-against-pancreatitis-and-concomitant-diseases-a-2025-perspective","Demystifying anti-inflammatory therapeutic strategies against pancreatitis and concomitant diseases - a 2025 perspective","","Pancreatitis is a complex, progressive inflammatory disorder that often transitions from acute to chronic stages, causing major comorbidities including diabetes, cardiovascular diseases, and bone disorders. These complications complicate treatment strategy selection and intensify the need for targeted interventions. Earlier approaches emphasized immune dysregulation, oxidative stress, and tissue damage, while newer research prioritizes anti-inflammatory mechanisms to reduce chronic inflammation and tissue injury, limit progression, and improve patient recovery. This review summarizes advances in anti-inflammatory therapies, including nanotechnology delivery systems and emerging gas-based, traditional Chinese medicine, gene therapy, specialty food, probiotics, exosomes, and multitarget approaches.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/demystifying-anti-inflammatory-therapeutic-strategies-against-pancreatitis-and-concomitant-diseases-a-2025-perspective/454014/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/demystifying-anti-inflammatory-therapeutic-strategies-against-pancreatitis-and-concomitant-diseases-a-2025-perspective/454014.png","ImageObject",300,407,{"name":42,"@type":43},"Rhys","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-10","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What major comorbidities are linked to pancreatitis progression?","Question",{"text":63,"@type":64},"Pancreatitis progression is associated with diabetes, cardiovascular diseases, and bone disorders. These complications make treatment strategies more difficult to manage effectively.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do recent therapeutic directions differ from historical approaches?",{"text":68,"@type":64},"Historically, therapies focused on immune dysregulation, oxidative stress, and tissue damage mechanisms. More recent work emphasizes anti-inflammatory mechanisms as primary targets to reduce chronic inflammation and tissue injury.",{"name":70,"@type":61,"acceptedAnswer":71},"Which emerging treatment modalities does the review highlight for anti-inflammatory therapy?",{"text":72,"@type":64},"The review highlights nanotechnology-based nanocarriers and also discusses gas-based therapies, traditional Chinese medicines, gene therapy, specialty food, living probiotics, exosomes, and multitargeted approaches.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},454014,1791099797,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146,"preview_page_count":4},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Theranostics 2026, Vol. 16, Issue 6 3050  \nIvyspring  \nInternational Publisher  \nTheranostics  \n2026; 16(6): 3050-3104. doi: 10.7150/thno.127402  \nReview  \nDemystifying anti-inflammatory therapeutic strategies against pancreatitis and concomitant diseases: a 2025 perspective  \nMengli Yue1,3, Sibtain Muhammad2, Song Jiang 3, Madappa C Maridevaru2, Yinghe Zhang2, Bing Guo2,􀀍, Pi Liu1,3,􀀍  \n1. Department of Gastroenterology, People's Hospital of Longhua Shenzhen, Shenzhen School of Clinical Medicine, Southern Medical University, China.  \n2. School of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.  \n3. Department of Gastroenterology, People's Hospital of Longhua, Shenzhen, 518109, China.  \n􀀍 Corresponding authors: [liupi1974@sina.com](liupi1974@sina.com) (Pi Liu); [guobing2020@hit.edu.cn](guobing2020@hit.edu.cn) (Bing Guo) .  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [https://ivyspring.com/terms](https://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2025.10.27; Accepted: 2025.11.24; Published: 2026.01.01  \nAbstract  \nPancreatitis is a complex, progressive inflammatory disorder that often transitions from acute to chronic stages, leading to significant comorbidities such as diabetes, cardiovascular diseases, and bone disorders. These complications complicate treatment strategies, highlighting the need for more targeted approaches. Historically, therapeutic strategies have focused on mechanisms addressing immune dysregulation, oxidative stress, and tissue damage. However, recent advancements have focused on anti-inflammatory mechanisms as primary therapeutic targets for pancreatitis and its associated conditions, as anti-inflammatory treatments help in alleviating chronic inflammation, minimizing tissue damage, and inhibiting disease progression, thereby enhancing recovery and overall patient well-being. This review highlights the most recent advancements in anti-inflammatory therapies for pancreatitis and associated diseases. We discuss how nanotechnology, particularly synthetic and biomimetic nanocarrier-based systems, has emerged as a promising approach to enhance the targeted delivery of anti-inflammatory agents, improving bioavailability and reducing systemic side effects. Importantly, we highlight the potential of gas-based therapies, traditional Chinese medicines, gene therapy, specialty food, living probiotics, exosomes, and even multitargeted approaches to enhance the therapeutic efficacy for pancreatitis and concomitant diseases. Despite these advancements, challenges such as treatment stability, immune response modulation, and scalability have been discussed. Moreover, perspective therapies such as single cell therapy and early diagnosis as treatments have been discussed. This review underscores the need for personalized, multimodal strategies to improve outcomes in pancreatitis management.  \nKeywords: oxidative stress, nanomedicine, anti-inflammation, Traditional Chinese Medicine, gas therapy, gene therapy  \n1. Introduction  \nPancreatitis is a pathological condition primarily triggered by the premature activation of digestive enzymes, particularly trypsinogen, within the pancreas, leading to autodigestion of pancreatic tissues [1] . The condition is generally categorized into two forms: acute pancreatitis (AP) and chronic pancreatitis (CP), which exhibit varying levels of inflammation, hemorrhage, and tissue necrosis that primarily affect the acinar cells and surrounding pancreatic tissues (Scheme 1A) [2] . While significant progress has been made in understanding the  \npathophysiology of AP, many aspects remain unclear [3] . The condition is associated with numerous etiological factors, such as gallstone-i","cbCaijyMZekNzSJE","https://ap.wps.com/l/cbCaijyMZekNzSJE","pdf",27483433,55,"English","# Introduction\n## Background and disease classification\n## Etiological factors and disease mechanisms\n## Disease severity and outcomes\n## Transition to chronic pancreatitis and diagnostic challenges\n## Current treatment approaches and limitations","[{\"question\":\"What major comorbidities are linked to pancreatitis progression?\",\"answer\":\"Pancreatitis progression is associated with diabetes, cardiovascular diseases, and bone disorders. These complications make treatment strategies more difficult to manage effectively.\"},{\"question\":\"How do recent therapeutic directions differ from historical approaches?\",\"answer\":\"Historically, therapies focused on immune dysregulation, oxidative stress, and tissue damage mechanisms. More recent work emphasizes anti-inflammatory mechanisms as primary targets to reduce chronic inflammation and tissue injury.\"},{\"question\":\"Which emerging treatment modalities does the review highlight for anti-inflammatory therapy?\",\"answer\":\"The review highlights nanotechnology-based nanocarriers and also discusses gas-based therapies, traditional Chinese medicines, gene therapy, specialty food, living probiotics, exosomes, and multitargeted approaches.\"}]","Demystifying anti-inflammatory therapeutic strategies against pancreatitis and concomitant diseases - a 2025 perspective | PDF",1790740018,139]