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Presenting 5 years after radical hysterectomy and adjuvant radiotherapy, she was initially presumed to have primary colorectal cancer based on colonoscopy and CT. The diagnosis was corrected using immunohistochemistry (IHC) after preliminary biopsy suggested adenocarcinoma. The report highlights rarity, frequent misdiagnosis, and the diagnostic value of IHC to guide management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/delayed-metastatic-endometrial-carcinoma-mimicking-primary-colon-adenocarcinoma-a-surprise-histopathological-finding/341252/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/delayed-metastatic-endometrial-carcinoma-mimicking-primary-colon-adenocarcinoma-a-surprise-histopathological-finding/341252.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why was the diagnosis initially suspected to be primary colorectal cancer?","Question",{"text":112,"@type":113},"Colonoscopy and CT showed features consistent with colorectal malignancy, and preliminary biopsy identified adenocarcinoma, leading to the presumption of a primary colon cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the final diagnosis established in this case?",{"text":117,"@type":113},"Immunohistochemistry (IHC) demonstrated tumor positivity for CK7, PAX8, and estrogen receptor (ER), supporting metastatic endometrial carcinoma rather than a primary colon adenocarcinoma.",{"name":119,"@type":110,"acceptedAnswer":120},"How long after hysterectomy did the colon metastasis present?",{"text":121,"@type":113},"The case presented 5 years after radical hysterectomy and adjuvant radiotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},341252,1790087993,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","DOI: 10. 1002/ccr3 .8925  \nCASE REPORT  \nDelayed metastatic endometrial carcinoma mimicking primary colon adenocarcinoma: A surprise histopathological finding  \nHui Yuan Foong1  | Jian Blundell1,2,3 | Cameron Law1,2 | Ross Warner1,2  \n1Department of General Surgery, The Tweed Hospital, New South Wales, Australia  \n2John Flynn Private Hospital, Queensland, Australia 3University of New South Wales, New South Wales, Australia  \nCorrespondence  \nJian Blundell, Department of General Surgery, The Tweed Hospital, 16-18 Powell St, Tweed Heads, NSW 2485, Australia.  \nEmail: [z3529264@unsw.edu.au](z3529264@unsw.edu.au)  \nKey Clinical Message  \nColorectal cancer is the third most common malignancy worldwide, with an increasing incidence. Colonic metastasis is a rare occurrence; thus, misdiagnosis is common. Immunohistochemistry facilitates accurate diagnosis and subsequent management.  \nAbstract  \nMost cancers in the colon are primary colorectal cancers, however metastasis from another primary is possible, albeit rare. Endometrial cancer metastasis to the colon is a rare occurrence and is only described in a handful of cases. We describe a rare case of metastatic endometrial cancer in the colon presenting 5 years post radical hysterectomy and adjuvant radiotherapy in a 62-year-old female. She presented with a 1-week history of right upper quadrant pain, with no other associated symptoms. She was presumed to have a primary colorectal cancer based on her colonoscopy and CT findings; later proven otherwise by immunohistochemistry (IHC) . Endometrial cancer metastasis to the colon is rare, thus misdiagnosis can easily occur. Currently, there are 6 similar cases reported in the literature, all occurring in the absence of colorectal endometriosis. This case illustrates the relative importance of considering colon as a potential site for metastasis of endometrial cancer and the utility of IHC in aiding diagnosis and guiding further management.  \nKEYWORDS  \ncolon metastasis, endometrial cancer, rectal metastasis, unusual site  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \n© 2024 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.  \nClin Case Rep. 2024;12:e8925 .  \n[https://doi.org/10.1002/ccr3.8925](https://doi.org/10.1002/ccr3.8925)  \n[wileyonlinelibrary.com/journal/ccr3](wileyonlinelibrary.com/journal/ccr3)  \n1 of 5  \n2 of 5  \n|  \nFOONG et al.  \n1 | INTRODUCTION  \nColorectal cancer (CRC) is the third most common cancer worldwide, accounting for 10% of all cancers and 9.4% of all cancer-related deaths in 2020.1 By 2030, the number of new CRC diagnoses is expected to increase by 60%, to over 2.2 million new cases worldwide. The rising incidence of CRC is mainly attributed to the increasing prevalence of obesity, alcohol and meat consumption, sedentary lifestyle, and an aging population.2 Patients with CRC maybe asymptomatic at diagnosis or have gastrointestinal symptoms such as bleeding, pain, change in bowel habit or bloating.3 A small subset of patients may even present with non-GI symptoms.1 Approximately 1% of all colon cancers are metastatic lesions from distal primaries.4 Recurrent endometrial carcinoma typically metastasizes to the peritoneum or lungs, whilst it is atypical for them to spread to the liver, adrenals, brain, bones, and soft tissue.5 In the current literature, endometrial cancer metastasis to the colon is a rare occurrence and is only described in a handful of cases. In this article, we describe an unusual case of endometrial cancer with a delayed metastasis to the colon.  \n2 | CASE HISTORY/ EXAMINATION  \nA 62-year-old female presented to a private gastroenterologist with 1 week of right upper quadrant pain, with no alterations in bowel habit, per rectum bleeding or me","cbCaiiNnCiP4pc4Q","https://ap.wps.com/l/cbCaiiNnCiP4pc4Q","pdf",983841,"English","# Key Clinical Message\n# Abstract\n# Introduction\n# Case History/Examination","[{\"question\":\"Why was the diagnosis initially suspected to be primary colorectal cancer?\",\"answer\":\"Colonoscopy and CT showed features consistent with colorectal malignancy, and preliminary biopsy identified adenocarcinoma, leading to the presumption of a primary colon cancer.\"},{\"question\":\"How was the final diagnosis established in this case?\",\"answer\":\"Immunohistochemistry (IHC) demonstrated tumor positivity for CK7, PAX8, and estrogen receptor (ER), supporting metastatic endometrial carcinoma rather than a primary colon adenocarcinoma.\"},{\"question\":\"How long after hysterectomy did the colon metastasis present?\",\"answer\":\"The case presented 5 years after radical hysterectomy and adjuvant radiotherapy.\"}]","Delayed metastatic endometrial carcinoma mimicking primary colon adenocarcinoma: A surprise histopathological finding | PDF",1790041124,13]