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Long non-coding RNAs (lncRNAs) are highlighted as pivotal regulators that orchestrate cancer-cell proliferation and migration. Targeting lncRNAs as therapeutic options and using them as prognostic markers are presented as promising directions. This comprehensive review analyzes molecular mechanisms linking lncRNAs to the onset and progression of the five major cancer types, including oncogenic and tumor-suppressive roles and context-dependent diversity, while also emphasizing aberrant expression patterns for screening and diagnosis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/decoding-long-non-coding-rnas-friends-and-foes-in-cancer-development-review/330643/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/decoding-long-non-coding-rnas-friends-and-foes-in-cancer-development-review/330643.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What roles do long non-coding RNAs (lncRNAs) play in cancer?","Question",{"text":113,"@type":114},"lncRNAs orchestrate key cancer processes such as proliferation and migration. They can also regulate gene expression and influence pathways related to apoptosis and immune regulation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the review describe lncRNAs’ functions across different cancer types?",{"text":118,"@type":114},"Some lncRNAs show context-dependent behavior, acting as oncogenic factors in certain cancers while behaving as tumor suppressors in others. This diversity complicates a single conventional understanding of their roles.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are lncRNAs considered useful for cancer screening and diagnosis?",{"text":122,"@type":114},"The review notes that many lncRNAs exhibit aberrant expression patterns across multiple cancer types. Such altered patterns are presented as potential indicators for screening and diagnosis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},330643,1790860359,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","INTERNATIONAL JOURNAL OF ONCOLOGY 64: 61, 2024  \nDecoding long non‑coding RNAs: Friends and foes in cancer development (Review)  \nHEQUN SONG 1* , JOSEPHADU‑AMANKWAAH2* , QIZHONG ZHAO3* , DONGQI YANG4 , KUNTAO LIU4 , AISHA BUSHI5 , JINMING ZHAO6,7 , JINXIANG YUAN8 and RUBIN TAN2  \n1First Clinical Medical School, Xuzhou Medical University, Xuzhou, Jiangsu 221004; 2Department of Physiology, Basic Medical School,  \n3  \nXuzhou Medical University, Xuzhou, Jiangsu 221004; Department of Emergency, The First Hospital of China Medical University, Shenyang, Liaoning 110122; 4School of Life Science and 5School of International Education, Xuzhou Medical University, Xuzhou,  \n6  \nJiangsu 221004; Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110122; 7Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning 110122; 8Lin He Academician Workstation of New Medicine and Clinical Translation, Jining Medical University, Jining, Shandong 272067, P.R. China  \nReceived November 3, 2023; Accepted April 2, 2024  \nDOI: 10.3892/ijo.2024.5649  \nAbstract. Cancer remains a formidable adversary, chal‑ lenging medical advancements with its dismal prognosis, low cure rates and high mortality rates. Within this intricate landscape, long non‑coding RNAs (lncRNAs) emerge as pivotal players, orchestrating proliferation and migration of cancer cells. Harnessing the potential of lncRNAs as thera‑ peutic targets and prognostic markers holds immense promise. The present comprehensive review delved into the molecular mechanisms underlying the involvement of lncRNAs in the onset and progression of the top five types of cancer. By meticulously examining lncRNAs across diverse types of cancer, it also uncovered their distinctive roles, highlighting their exclusive oncogenic effects or tumor suppressor proper‑ ties. Notably, certain lncRNAs demonstrate diverse functions across different cancers, confounding the conventional understanding of their roles. Furthermore, the present study identified lncRNAs exhibiting aberrant expression patterns in numerous types of cancer, presenting them as potential indica‑ tors for cancer screening and diagnosis. Conversely, a subset of  \nCorrespondence to: Dr Rubin Tan, Department of Physiology, Basic Medical School, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, P.R. China  \nE‑mail: [tanrubin11@126.com](tanrubin11@126.com)  \nProfessor Jinxiang Yuan, Lin He Academician Workstation of New Medicine and Clinical Translation, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, Shandong 272067, P.R. China  \nE‑mail: [yuanjinxiang18@163.com](yuanjinxiang18@163.com)  \n*Contributed equally  \nKey words: lncRNAs, oncogenic, cancer‑suppressing, proliferation, invasion metastasis  \nlncRNAs manifests tissue‑specific expression, hinting at their specialized nature and untapped significance in diagnosing and treating specific types of cancer. The present compre‑ hensive review not only shed light on the intricate network of lncRNAs but also paved the way for further research and clinical applications. The unraveled molecular mechanisms offer a promising avenue for targeted therapeutics and person‑ alized medicine, combating cancer proliferation, invasion and metastasis.  \nContents  \n1. Introduction  \n2. Overview of the top five types of cancer  \n3. lncRNAs as oncogenes in the top five types of cancer  \n4. lncRNAs as tumor suppressors in the top five types of cancer  \n5. lncRNAs acting as both oncogenes and tumor suppressors during cancer development  \n6. Conclusion and prospects  \n1. Introduction  \nCancer stands as one of the most perilous diseases, with its incidence and fatality rates consistently occupying the top positions among non‑communicable diseases (1) . In 2020, the world witnessed ~19 .3 million fresh cases of cancer and nearly 10.0 million cancer‑related fatalities (2) . There have been significant advance","cbCaibIJawTUyIwH","https://ap.wps.com/l/cbCaibIJawTUyIwH","pdf",3943764,22,"English","# Introduction\n# Overview of the top five types of cancer\n# lncRNAs as oncogenes in the top five types of cancer\n# lncRNAs as tumor suppressors in the top five types of cancer\n# lncRNAs acting as both oncogenes and tumor suppressors during cancer development\n# Conclusion and prospects","[{\"question\":\"What roles do long non-coding RNAs (lncRNAs) play in cancer?\",\"answer\":\"lncRNAs orchestrate key cancer processes such as proliferation and migration. They can also regulate gene expression and influence pathways related to apoptosis and immune regulation.\"},{\"question\":\"How does the review describe lncRNAs’ functions across different cancer types?\",\"answer\":\"Some lncRNAs show context-dependent behavior, acting as oncogenic factors in certain cancers while behaving as tumor suppressors in others. This diversity complicates a single conventional understanding of their roles.\"},{\"question\":\"Why are lncRNAs considered useful for cancer screening and diagnosis?\",\"answer\":\"The review notes that many lncRNAs exhibit aberrant expression patterns across multiple cancer types. Such altered patterns are presented as potential indicators for screening and diagnosis.\"}]","Decoding long non-coding RNAs - Friends and foes in cancer development - Review | PDF",1789989625,55]