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This study screens immune-related gene expression to identify CRC and adenomatous polyp genes in a Norwegian cohort, evaluating their potential as detection biomarkers and early indicators of 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\nDavid Gibbons,  \nSt. Vincent ’s University Hospital, Ireland  \nREVIEWED BY Sweta Ghosh,  \nUniversity of Louisville, United States Anne Jarry,  \nInstitut National de la Sante´ et de la Recherche Me´ dicale (INSERM), France  \n*CORRESPONDENCE Thura Akrem Omran  \n [thura.omran@gmail.com](thura.omran@gmail.com)  \n†These authors share senior authorship  \nRECEIVED 27 March 2024  \nACCEPTED 10 June 2024  \nPUBLISHED 24 June 2024  \nCITATION  \nOmran TA, Tunsjø HS, Jahanlu D, Brackmann SA, Bemanian V and Sæther PC (2024) Decoding immune-related genesignatures in colorectal neoplasia.  \nFront. Immunol. 15:1407995 .  \ndoi: 10.3389/fimmu.2024.1407995  \nCOPYRIGHT  \n© 2024 Omran, Tunsjø, Jahanlu, Brackmann, Bemanian and Sæther. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) .  \nThe use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nDecoding immune-related genesignatures in colorectal neoplasia  \nThura Akrem Omran 1*, Hege Smith Tunsjø 1, David Jahanlu 1, Stephan Andreas Brackmann 2,3, Vahid Bemanian 4† and Per Christian Sæther 5†  \n1 Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway, 2 Division of Medicine, Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway,  \n3 Institute for Clinical Medicine, University of Oslo, Oslo, Norway, 4 Department of Pathology, Akershus University Hospital, Lørenskog, Norway, 5 Department of Immunology and Transfusion Medicine, Akershus University Hospital, Lørenskog, Norway  \nBackground: Colorectal cancer (CRC) is a significant health issue, with notable incidence rates in Norway. The immune response plays a dual role in CRC, offering both protective effects and promoting tumor growth. This research aims to provide a detailed screening of immune-related genes and identify specific genes in CRC and adenomatous polyps within the Norwegian population, potentially serving as detection biomarkers.  \nMethods: The study involved 69 patients (228 biopsies) undergoing colonoscopy, divided into CRC, adenomatous polyps, and control groups. We examined the expression of 579 immune genes through nCounter analysis emphasizing differential expression in tumor versus adjacent non-tumoroustissue and performed quantitative reverse transcription polymerase chain reaction (RT-qPCR) across patient categories.  \nResults: Key findings include the elevated expression of CXCL1, CXCL2, IL1B, IL6, CXCL8 (IL8), PTGS2, and SPP1 in CRC tissues. Additionally, CXCL1, CXCL2, IL6, CXCL8, and PTGS2 showed significant expression changes in adenomatous polyps, suggesting their early involvement in carcinogenesis.  \nConclusions: This study uncovers a distinctive immunological signature in colorectal neoplasia among Norwegians, highlighting CXCL1, CXCL2, IL1B, IL6, CXCL8, PTGS2, and SPP1 as potential CRC biomarkers. These findings warrant further research to confirm their role and explore their utility in non-invasive screening strategies.  \nKEYWORDS  \ncolorectal cancer (CRC), immunology, biomarker potential, adenomatous polyps, gene expression, Norway  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nColorectal cancer (CRC) is one of the most common cancer types and the leading cause of cancer-related mortality and morbidity across the world. Norway has one of the world’s highest rates of CRC, with 4745 newly diagnosed cases in 2022 (1) . The reasons for such a high incidence of CRC in Norway remain unknown. Environmental factors such as diet and lifestyle, as well as genetic disposition, contribute to the development ","cbCaihlcNx35Enlm","https://ap.wps.com/l/cbCaihlcNx35Enlm","pdf",3504144,17,"English","# Introduction\n## Immune system roles in CRC\n## Tumor microenvironment and immunological interactions\n## Study rationale","[{\"question\":\"What was the aim of this research on colorectal neoplasia?\",\"answer\":\"To screen immune-related genes and identify specific genes in CRC and adenomatous polyps in the Norwegian population for potential detection biomarkers.\"},{\"question\":\"How was gene expression measured in the study?\",\"answer\":\"Immune gene expression was assessed using nCounter analysis across tumor versus adjacent non-tumor tissue, followed by RT-qPCR across patient categories.\"},{\"question\":\"Which immune-related genes showed increased expression in CRC tissues?\",\"answer\":\"CXCL1, CXCL2, IL1B, IL6, CXCL8 (IL8), PTGS2, and SPP1 were elevated in CRC tissues.\"}]","Decoding immune-related gene-signatures in colorectal neoplasia | PDF",1789979301,43]