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\nKingston Rajiah,  \nUlster University, United Kingdom  \nREVIEWED BY  \nArnaud John Kombe Kombe,  \nUniversity of Texas Southwestern Medical Center, United States  \nGuy-Armel Bounda,  \nChina Pharmaceutical University, China  \n*CORRESPONDENCE  \nXiangqin Zheng  \n [Zhengxq1215@163.com](Zhengxq1215@163.com)[ ](Zhengxq1215@163.com)Huan Yi  \n [yi.huan@fjmu.edu.cn](yi.huan@fjmu.edu.cn)[ ](yi.huan@fjmu.edu.cn)Jianrong Song  \n [sjr0318@163.com](sjr0318@163.com)  \n†These authors have contributed equally to this work  \nRECEIVED 17 December 2023  \nACCEPTED 16 May 2024  \nPUBLISHED 06 June 2024  \nCITATION  \nZhang Y, Li H, You Q, Chen Y, Zhao Z, Chen J, Su Y, Zheng X, Yi H and Song J (2024)  \nDecoding Fujian’s cervical HPV landscape: unmasking dominance of non-16/18 HR-HPV and tailoring prevention strategies at a large scale.  \nFront. Public Health 12:1357073 .  \ndoi: 10.3389/fpubh.2024.1357073  \nCOPYRIGHT  \n© 2024 Zhang, Li, You, Chen, Zhao, Chen, Su, Zheng, Yi and Song. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nDecoding Fujian’s cervical HPV landscape: unmasking dominance of non-16/18 HR-HPV and tailoring prevention strategies at a large scale  \nYulong Zhang 1†, Haibo Li 2†, Qianru You 1†, Yusha Chen3, Ziyan Zhao4, Jiancui Chen3, Yanzhao Su 1, Xiangqin Zheng 1*, Huan Yi 1*and Jianrong Song 1*  \n1 Department of Gynecology, Fujian Province Key Clinical Specialty for Gynecology, National Key Gynecology Clinical Specialty Building Institution, Fujian Maternity and Child Health Hospital College of Clinical Medical for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China, 2 Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China,  \n3Cervical Disease Diagnosis and Treatment Health Center, Fujian Maternity and Child Health Hospital College of Clinical Medical for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China, 4 Department of Integrative Biology, University of California-Berkeley, Berkeley, CA, United States  \nBackground: Persistent HR-HPV causes cervical cancer, exhibiting geographic variance. Europe/Americas have higher HPV16/18 rates, while Asia/Africa predominantly have non-16/18 HR-HPV. This study in Fujian, Asia, explores non-16/18 HR-HPV infections, assessing their epidemiology and cervical lesion association for targeted prevention.  \nMethods: A total of 101,621 women undergoing HPV screening at a hospital in Fujian Province from 2013 to 2019 were included. HPV genotyping was performed. A subset of 11,666 HPV-positive women with available histopathology results were analyzed to characterize HPV genotype distribution across cervical diagnoses.  \nResults: In 101,621 samples, 24.5% tested positive for HPV. Among these samples, 17.3% exhibited single infections, while 7. 2% showed evidence of multiple infections. The predominant non-16/18 high-risk HPV types identified were HPV 52, 58, 53, 51, and 81. Single HPV infections accounted for 64.1% of all HPVpositive cases, with 71 .4% of these being non-16/18 high-risk HPV infections. Agerelated variations were observed in 11,666 HPV-positive patients with pathological results. Cancer patients were older. In the cancer group, HPV52 (21 .8%) and HPV58 (18 .6%) were the predominant types, followed by HPV33, HPV31, and HPV53 . Compared to single HPV16/18 infection, non-16/18 HPV predominated in LSIL. Adj","cbCaisGYiLU8obsI","https://ap.wps.com/l/cbCaisGYiLU8obsI","pdf",2304231,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What was the main goal of this Fujian-based study on cervical HPV?\",\"answer\":\"To characterize non-16/18 HR-HPV infections in Fujian by describing epidemiology and evaluating associations with cervical lesions to support targeted prevention.\"},{\"question\":\"How many women were included, and what time period did the screening cover?\",\"answer\":\"A total of 101,621 women were included, undergoing HPV screening at a hospital in Fujian Province from 2013 to 2019.\"},{\"question\":\"Which HR-HPV types were identified as predominant non-16/18 types?\",\"answer\":\"The predominant non-16/18 HR-HPV types identified were HPV 52, 58, 53, 51, and 81.\"}]","Decoding Fujian’s cervical HPV landscape - unmasking dominance of non-16/18 HR-HPV and tailoring prevention strategies at a large scale | PDF",1790031027,23]