[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329117-105":59,"doc-detail-329117-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","deciphering-the-igf2bp3-mediated-control-of-ferroptosis-mechanistic-insights-and-therapeutic-prospects","Deciphering the IGF2BP3-mediated control of ferroptosis - mechanistic insights and therapeutic prospects","","The rapid expansion of oncology research has clarified cell-death pathways with special emphasis on ferroptosis. Ferroptosis is an iron-dependent form of programmed cell demise driven by lipid-peroxide accumulation and iron buildup, disrupting cellular redox balance. This analysis highlights IGF2BP3, an RNA-binding protein, as a key regulator within the ferroptosis network in cancer cells. IGF2BP3 post-transcriptionally controls genes tied to iron homeostasis, shaping intracellular iron levels and reactive oxygen species (ROS) equilibrium. Aberrant IGF2BP3 expression correlates with aggressive phenotypes, metastatic ability, and poor prognosis, while supporting its evaluation as a biomarker and therapeutic strategy to sensitize tumors to ferroptosis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/deciphering-the-igf2bp3-mediated-control-of-ferroptosis-mechanistic-insights-and-therapeutic-prospects/329117/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/deciphering-the-igf2bp3-mediated-control-of-ferroptosis-mechanistic-insights-and-therapeutic-prospects/329117.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is ferroptosis and why is it considered iron-dependent?","Question",{"text":113,"@type":114},"Ferroptosis is a programmed form of cell death uniquely hinged on iron. It features lipid peroxidation and iron-ion accumulation, which disrupts antioxidant defenses such as GPX4, ultimately triggering cell demise.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does IGF2BP3 regulate ferroptosis in cancer cells?",{"text":118,"@type":114},"IGF2BP3 regulates ferroptosis through post-transcriptional control of genes related to iron equilibrium. By managing cellular iron concentrations and ROS balance, it influences the cell’s fate toward survival or death.",{"name":120,"@type":111,"acceptedAnswer":121},"What clinical relevance does IGF2BP3 have in cancer?",{"text":122,"@type":114},"Aberrant IGF2BP3 expression is linked with increased aggressiveness, metastatic capacity, and poor prognosis across cancers. The text also considers IGF2BP3 as a potential prognostic biomarker and a therapeutic target to enhance tumor vulnerability to ferroptosis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},329117,1790007628,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","Review  \nDeciphering the IGF2BP3‑mediated control offerroptosis: mechanistic insights and therapeutic prospects  \nWenjuan Zhang1 · Hui Liu1 · Changrong Ren1 · Kaiqian Zhang1 · Shuhan Zhang2 · Shifan Shi1 · Zhiyan Li1 · Jian Li3  \nReceived: 22 July 2024 / Accepted: 7 October 2024  \n© The Author(s) 2024 OPEN  \nAbstract  \nThe rapid expansion of the oncology field has revealed new insights into cell death processes, with aparticular emphasis on the role of ferroptosis. Characterized by iron dependency and the accumulation of lipid peroxides and iron within cells, ferroptosis stands out as a unique form of programmed cell demise. This in-depth analysis delves into the pivotal role of IGF2BP3, an RNA-binding protein, in the complex regulatory network offerroptosis in cancerous cells. By exerting post-transcriptional control over genes associated with iron equilibrium, IGF2BP3 is demonstrated to manage cellular iron concentrations and reactive oxygen species (ROS) equilibrium, thus affecting the destiny of the cell. The correlation between aberrant IGF2BP3 expression and increased aggressiveness, metastatic capacity, and poor prognosis in various cancers is further clarified. The potential of IGF2BP3 as a biomarker for prognosis and a therapeutic agent to enhance cancer cells’ vulnerability to ferroptosis is also examined, heralding new strategies in cancer treatment.  \nKeywords IGF2BP3 · Ferroptosis · Iron metabolism · Reactive oxygen species (ROS) · Cancer therapeutics  \nAbbreviations  \nROS Reactive oxygen species  \nIGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 GPX4 Glutathione peroxidase 4  \nGPXs Glutathione Peroxidases  \nRRMs Recognition motifs KH K homology FPN1 Ferroportin-1  \nACSL4 Acyl-CoA synthetase long-chain family member 4  \nHCC Hepatocellular carcinoma LUAD Lung adenocarcinoma CRC Colorectal cancer  \nm6A N6-methyladenosine  \nRSA Recurrent spontaneous abortion AML Acute myeloid leukemia  \nLico A Licochalcone A  \n* Jian Li, [Cdmulijian79@163.com |](Cdmulijian79@163.com |1Affiliated Hospital of Chengde Medical University)[1](Cdmulijian79@163.com |1Affiliated Hospital of Chengde Medical University)[Affiliated Hospital of Chengde Medical University](Cdmulijian79@163.com |1Affiliated Hospital of Chengde Medical University), NO.36 NanYingZi Road, Chengde 067000, HeBei, China. 2Department of Hepatobiliary Surgery, Air Force Medical Center, PLA, Air Force Medical University, Beijing, China. 3Department of Hepatobiliary Surgery, Hebei Key Laboratory of Panvascular Diseases, Affiliated Hospital of Chengde Medical University, NO.36 NanYingZi Road, Chengde 067000, HeBei, China.  \nDiscover Oncology  \n(2024) 15:547  \n| [https://doi.org/10.1007/s12672-024-01432-z](https://doi.org/10.1007/s12672-024-01432-z)  \nCOPD Chronic obstructive pulmonary disease DEGs Differentially expressed genes NCOA4 Nuclear receptor coactivator 4  \n1 Introduction  \nWith the in-depth development of biomedical research, the complex mechanism of cell death and its potential application in tumor therapy have gradually attracted wide attention, with a particular focus on the emergent and promising phenomenon of ferroptosis. Ferroptosis, a form of cell death uniquely hinged on iron, stands out for its distinctive reliance on this metal as a central element in its execution, was first observed during a cancer cell screen in 2003 and later formally defined by Stockwell et al. [1].This process is marked by the peroxidation of lipids and the accumulation of iron ions within the cell, resulting in the dysfunction of the essential antioxidant enzyme known as glutathione peroxidase 4 (GPX4), which in turn triggers programmed cell death [2] . Ferroptosis sets itself apart from the typical apoptotic cell death by its unique pathological markers; it is identified by a significant escalation in the oxidation of lipids and an irregular buildup of iron within the cell. This disruption to the cell’s delicate redox balance initiates a cascade of events that culminate","cbCaideKeMnPvjaB","https://ap.wps.com/l/cbCaideKeMnPvjaB","pdf",1951320,15,"English","# Introduction\n## Ferroptosis as an iron-dependent programmed cell death\n## Cellular redox disruption and ferroptosis inducers/inhibitors\n## IGF2BP3: gene features and RNA-binding function","[{\"question\":\"What is ferroptosis and why is it considered iron-dependent?\",\"answer\":\"Ferroptosis is a programmed form of cell death uniquely hinged on iron. It features lipid peroxidation and iron-ion accumulation, which disrupts antioxidant defenses such as GPX4, ultimately triggering cell demise.\"},{\"question\":\"How does IGF2BP3 regulate ferroptosis in cancer cells?\",\"answer\":\"IGF2BP3 regulates ferroptosis through post-transcriptional control of genes related to iron equilibrium. By managing cellular iron concentrations and ROS balance, it influences the cell’s fate toward survival or death.\"},{\"question\":\"What clinical relevance does IGF2BP3 have in cancer?\",\"answer\":\"Aberrant IGF2BP3 expression is linked with increased aggressiveness, metastatic capacity, and poor prognosis across cancers. The text also considers IGF2BP3 as a potential prognostic biomarker and a therapeutic target to enhance tumor vulnerability to ferroptosis.\"}]","Deciphering the IGF2BP3-mediated control of ferroptosis - mechanistic insights and therapeutic prospects | PDF",1789982549,38]