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into the Biology and Therapeutic Strategies of Gliomas  \nRazvan Onciul 1,2,†, Felix-Mircea Brehar 1,3,*, Corneliu Toader 1,4,†, Razvan-Adrian Covache-Busuioc 1,  \nLuca-Andrei Glavan 1, Bogdan-Gabriel Bratu 1, Horia Petre Costin 1, David-Ioan Dumitrascu 1, Matei Serban 1 and Alexandru Vlad Ciurea 1,5  \nCitation: Onciul, R.; Brehar, F.-M.; Toader, C.; Covache-Busuioc, R.-A.; Glavan, L.-A.; Bratu, B.-G.; Costin, H.P.; Dumitrascu, D.-I.; Serban, M.; Ciurea, A.V. Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas. Curr. Issues Mol. Biol. 2024, 46, 2402–2443. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/cimb46030153](10.3390/cimb46030153)  \nAcademic Editor: Joana Márquez  \nReceived: 24 January 2024  \nRevised: 6 March 2024  \nAccepted: 9 March 2024  \nPublished: 13 March 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Neurosurgery,“Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; [razvan.onciul@drd.umfcd.ro](razvan.onciul@drd.umfcd.ro) (R.O.); [corneliu.toader@umfcd.ro](corneliu.toader@umfcd.ro) (C.T.); [razvan-adrian.covache-busuioc0720@stud.umfcd.ro](razvan-adrian.covache-busuioc0720@stud.umfcd.ro) (R.-A.C.-B.); [luca-andrei.glavan0720@stud.umfcd.ro](luca-andrei.glavan0720@stud.umfcd.ro) (L.-A.G.); [bogdan.bratu@stud.umfcd.ro](bogdan.bratu@stud.umfcd.ro) (B.-G.B.); [horia-petre.costin0720@stud.umfcd.ro](horia-petre.costin0720@stud.umfcd.ro) (H.P.C.); [david-ioan.dumitrascu0720@stud.umfcd.ro](david-ioan.dumitrascu0720@stud.umfcd.ro) (D.-I.D.); [matei.serban2021@stud.umfcd.ro](matei.serban2021@stud.umfcd.ro) (M.S.); [prof.avciurea@gmail.com](prof.avciurea@gmail.com) (A.V.C.)  \n2 Neurosurgery Department, Emergency University Hospital, 050098 Bucharest, Romania  \n3 Department of Neurosurgery, Clinical Emergency Hospital “Bagdasar-Arseni”, 041915 Bucharest, Romania  \n4 Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases,  \n077160 Bucharest, Romania  \n5 Neurosurgery Department, Sanador Clinical Hospital, 010991 Bucharest, Romania  \n* Correspondence: [felix.brehar@umfcd.ro](felix.brehar@umfcd.ro)  \n† These authors contributed equally to this work.  \nAbstract: Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies. Moreover, we accentuate critical developments in understanding tumor behavior, focusing on recent research breakthroughs in treatment responsesand the elucidation of cellular signaling pathways. Analyzing the most novel transcriptomic studies, we investigate the variations in gene expression patterns in glioma cells, assessing the prognostic and therapeutic implications of these genetic alterations. Furthermore, the role of epigenetic modifications in the pathogenesis of gliomas is underscored, suggesting that such changes are fundamental to tumor evolution and possible therapeutic advancements. In the end, this comparative oncological analysis situates GBM within the wider context of neoplasms, delineating both distinc","cbCainVuihoonYFY","https://ap.wps.com/l/cbCainVuihoonYFY","pdf",2862711,42,"English","# Introduction\n# Abstract\n# Keywords","[{\"question\":\"What is the focus of the review on glioblastoma?\",\"answer\":\"The review emphasizes glioblastoma within the broader glioma landscape, covering its classification, epidemiology, immunological context, and recent advances in therapeutic understanding.\"},{\"question\":\"How does the review describe progression in gliomas?\",\"answer\":\"It outlines glioma progression as developmental stages, including early transformation, invasion capability, increased proliferation, disrupted cell-cycle control, enhanced angiogenesis, and clonal evolution that drives heterogeneity.\"},{\"question\":\"What molecular research areas are highlighted in the review?\",\"answer\":\"The review highlights transcriptomic studies of gene-expression patterns and the role of epigenetic modifications in glioma pathogenesis, linking these changes to prognosis and therapeutic potential.\"}]","Deciphering Glioblastoma - Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas | PDF",1790215846,106]