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DEAD-box helicase family proteins, core members of the RNA helicase network, regulate RNA metabolism and influence cancer development and progression. 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Journal of Translational Medicine (2024) 22:1120  \n[https://doi.org/10.1186/s12967-024-05930-0](https://doi.org/10.1186/s12967-024-05930-0)  \nJournal of Translational Medicine  \n REVIEW Open Access  \nDEAD-box helicase family proteins:  \nemerging targets in digestive system cancersand advances in targeted drug development  \nXiaochao Ma1, Tianyu Lu1, Yue Yang1, Da Qin1, ZeTang1, Youbin Cui1* and Rui Wang1*  \nAbstract  \nCancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17. 1% of all newly diagnosed cancer cases worldwide. Despite significant improvements in early cancer screening, clinical diagnostics, and treatmentsin recent years, the overall prognosis of digestive system cancer patients remains poor. The DEAD-box helicase family, a crucial member ofthe RNA helicase family, participates in almost every aspect of RNA metabolism, including transcription, splicing, translation, and degradation, and plays a key role in the occurrence and progression of various cancers. This article aims to summarize and discuss the role and potential clinical applications of DEAD-box helicase family proteins in digestive system cancers. The discussion includes the latest progress in the occurrence, development, and treatment of esophageal and gastrointestinal tumors; the main functions of DEAD-box helicase family proteins; their roles in digestive system cancers, including their relationships with clinical factors; effects on cancer proliferation, migration, and invasion; and involved signaling pathways; as well as the existing inhibitory strategies targeting DDX family proteins, are discussed. Additionally, outlooks on future research directions are provided.  \nKeywords DEAD-box helicase, Esophageal cancer, Gastrointestinal cancer  \nIntroduction  \nCancer is one of the leading chronic non-communicable diseases worldwide, accounting for approximately 16.8% of global deaths, with esophageal and gastrointestinal cancers contributing significantly to this burden. In 2022, new cases of esophageal and gastrointestinal cancers represented 17.1% of all cancers globally. Colorectal cancer ranked third (9.6%), gastric cancer fifth (4.9%), and esophageal cancer eleventh (2.6%). Among cancer-related deaths, these cancers accounted for 20.7%, with colorectal cancer ranked second (9.3%), gastric cancer fifth  \n*Correspondence: Youbin Cui [cuiyb@jlu.edu.cn](cuiyb@jlu.edu.cn)[ ](cuiyb@jlu.edu.cn)Rui Wang  \n1 Department of Thoracic Surgery, Organ Transplantation Center, the First Hospital of Jilin University, 1 Ximin Street, ChangchunJilin 130021, China  \n(6.8%), and esophageal cancer seventh (4.6%) [1]. Despite advancements in treatment, the mortality rates remain high, underscoring the urgent need for new therapeutic targets.  \nThe transmission of genetic information in RNA relies on the changes in its secondary structure [2], with RNA helicases playing a crucial role in regulating these structural transitions. RNA helicases are widely distributed and highly conserved, participating in multiple biological processes, including transcription, splicing, degradation, and translation [3]. Based on conserved motifs, RNA helicases are categorized into different families (SF1-SF5), among which the DEAD-box helicase family is the largest [4]. DEAD-box helicases are involved in DNA transcription, mRNA splicing, ribosome biogenesis, RNA transport, translation, degradation, cell cycle regulation, and  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed ma","cbCaihXTGvulhdYd","https://ap.wps.com/l/cbCaihXTGvulhdYd","pdf",2560257,26,"English","# Abstract\n# Introduction\n## Cancer burden and need for new targets\n## RNA helicases and DEAD-box helicases\n## DEAD-box helicases in digestive system tumors","[{\"question\":\"Why are digestive system cancers a critical focus for new therapies?\",\"answer\":\"They represent a large portion of worldwide cancer incidence and cancer-related deaths. Even with advances in screening and treatment, overall prognosis remains poor, creating an urgent need for novel therapeutic targets.\"},{\"question\":\"What roles do DEAD-box helicase family proteins play in cells?\",\"answer\":\"They participate in RNA metabolism processes such as transcription, splicing, translation, and degradation. These functions connect them to regulation of cancer-related events including proliferation and apoptosis.\"},{\"question\":\"What does the review cover about DEAD-box helicases in digestive system cancers?\",\"answer\":\"It discusses latest progress in occurrence, development, and treatment, core functions, relationships with clinical factors, effects on proliferation, migration, and invasion, and involved signaling pathways. It also reviews existing inhibitory strategies targeting DDX family proteins and provides future research outlooks.\"}]","DEAD-box helicase family proteins - emerging targets in digestive system cancers and advances in targeted drug development - review open access | PDF",1789985063,66]