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This review analyzes DDX10’s structural and functional properties and its emerging roles in solid tumors and hematologic malignancies. It connects DDX10 to pre-rRNA processing, ribosome biogenesis, cell proliferation, liquid–liquid phase separation (LLPS), and epigenetic regulation. Dysregulated DDX10 expression is described as recurrent across cancers, promoting tumor progression, therapy resistance, poor prognosis, and oncogenic transformation, including NUP98::DDX10 fusion in acute myeloid leukemia. The article positions DDX10 as a potential diagnostic biomarker and therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ddx10-rna-helicase-structure-function-and-oncogenic-roles-across-solid-and-hematologic-tumors/353779/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ddx10-rna-helicase-structure-function-and-oncogenic-roles-across-solid-and-hematologic-tumors/353779.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are DEAD-box RNA helicases, and why is DDX10 important?","Question",{"text":112,"@type":113},"DEAD-box (DDX) RNA helicases regulate RNA metabolism and gene expression. DDX10 is increasingly implicated in human diseases, yet remains poorly characterized, motivating the review’s comprehensive analysis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does DDX10 contribute to RNA processing and cancer-related cellular functions?",{"text":117,"@type":113},"DDX10 is discussed as contributing to pre-rRNA processing and ribosome biogenesis, supporting cell proliferation. The review also links DDX10 to LLPS and epigenetic regulation, which may underlie cancer cell plasticity and stress response.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence links DDX10 to oncogenesis and clinical outcomes?",{"text":121,"@type":113},"The review states that aberrant DDX10 expression is recurrent across multiple cancers and is associated with tumor progression, therapy resistance, and poor prognosis. It also highlights oncogenic roles involving the NUP98::DDX10 fusion in a subset of acute myeloid leukemias.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353779,1790187046,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","Review  \nDDX10 RNA Helicase: Structure, Function, and Oncogenic Roles Across Solid and Hematologic Tumors  \nGiorgia Isinelli 1,†, Genny Scacci 1,†, Arianna Capocchia 1, Carla Emiliani 1, Cristina Mecucci 2, Roberta La Starza 2 and Danika Di Giacomo 1, *  \nAcademic Editor: M. Andres Blanco  \nReceived: 18 December 2025  \nRevised: 2 January 2026  \nAccepted: 23 January 2026  \nPublished: 27 January 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy; [giorgia.isinelli@unipg.it](giorgia.isinelli@unipg.it) (G.I.); [genny.scacci@dottorandi.unipg.it](genny.scacci@dottorandi.unipg.it) (G.S.); [arianna.capocchia@studenti.unipg.it](arianna.capocchia@studenti.unipg.it) (A.C.); [carla.emiliani@unipg.it](carla.emiliani@unipg.it) (C.E.)  \n2 Hematology and Bone Marrow Transplantation Unit, Department of Medicine and Surgery, CREO, Azienda Ospedaliera di Perugia, University of Perugia, 06100 Perugia, Italy; [cristina.mecucci@unipg.it](cristina.mecucci@unipg.it) (C.M.); [roberta.lastarza@unipg.it](roberta.lastarza@unipg.it) (R.L.S.)  \n* Correspondence: [danika.digiacomo@unipg.it](danika.digiacomo@unipg.it)[ ](danika.digiacomo@unipg.it)† These authors contributed equally to this work.  \nAbstract  \nDEAD-box (DDX) RNA helicases are essential regulators of RNA metabolism and gene expression. Among them, DDX10 remains poorly characterized despite growing evidence supporting its involvement in human diseases. This review provides a comprehensive analysis of DDX10, from its structural and functional features to its emerging roles in solid tumors and hematologic malignancies. We discuss how DDX10, through its conserved domains, contributes to pre-rRNA processing, ribosome biogenesis, and cell proliferation, and explore potential links between DDX10 and processes such as liquid–liquid phase separation (LLPS) and epigenetic regulation, which may underlie its roles in cancer cell plasticity and stress response. We argue that the dysregulation of these fundamental cellular processes positions DDX10 as a focal point where aberrant RNA metabolism and altered molecular condensates converge to disrupt transcriptional homeostasis and drive oncogenic transformation. Aberrant DDX10 expression is a recurrent feature across multiple cancers, where it promotes tumor progression, therapy resistance, and poor prognosis. Moreover, DDX10 participates in oncogenic fusion events, most notably the NUP98::DDX10 fusion identified in a subset of acute myeloid leukemias, which drives leukemogenesis by disrupting transcriptional regulation and cellular differentiation. Given its tumor-associated expression and diverse biological functions, DDX10 is increasingly recognized as a potential diagnostic biomarker and a promising target for therapeutic strategies. By consolidating current knowledge under this unifying framework, this review highlights the multifaceted roles of DDX10 in cancer biology, advocating further research into its molecular functions and translational potential.  \nKeywords: DDX10; DEAD-box RNA helicase; ribosome biogenesis; NUP98::DDX10 fusion; acute myeloid leukemia (AML); solid tumors; liquid–liquid phase separation (LLPS); epigenetic regulation; oncogenic transformation; tumor biomarker  \n1. Introduction  \nDDXhelicases constitute a family of Adenosine Triphosphate Protein (ATP)-dependent RNA helicases, classified under the helicase superfamily 2 (SF2), which is the largest family of nucleic acid helicases [1] . DEAD-box RNA helicases possess a highly conserved core  \nregion characterized by twelve signature motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif. These elements are crucial for their ATPase activity and RNA-unwinding functions, which define their role as RNA helicases [2] . They perfo","cbCaiaDeDmsC5dJ9","https://ap.wps.com/l/cbCaiaDeDmsC5dJ9","pdf",2559414,"English","# Abstract\n## Keywords\n# Introduction","[{\"question\":\"What are DEAD-box RNA helicases, and why is DDX10 important?\",\"answer\":\"DEAD-box (DDX) RNA helicases regulate RNA metabolism and gene expression. DDX10 is increasingly implicated in human diseases, yet remains poorly characterized, motivating the review’s comprehensive analysis.\"},{\"question\":\"How does DDX10 contribute to RNA processing and cancer-related cellular functions?\",\"answer\":\"DDX10 is discussed as contributing to pre-rRNA processing and ribosome biogenesis, supporting cell proliferation. The review also links DDX10 to LLPS and epigenetic regulation, which may underlie cancer cell plasticity and stress response.\"},{\"question\":\"What evidence links DDX10 to oncogenesis and clinical outcomes?\",\"answer\":\"The review states that aberrant DDX10 expression is recurrent across multiple cancers and is associated with tumor progression, therapy resistance, and poor prognosis. It also highlights oncogenic roles involving the NUP98::DDX10 fusion in a subset of acute myeloid leukemias.\"}]","DDX10 RNA Helicase - Structure, Function, and Oncogenic Roles Across Solid and Hematologic Tumors | PDF",1790107178,48]