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Pan-cancer analyses show distinct expression profiles and critical prognostic value in most cancers, with high melanoma expression tied to poor outcomes and greater malignancy.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/dclre1b-as-a-novel-prognostic-biomarker-associated-with-immune-infiltration-a-pancancer-analysis/332918/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/dclre1b-as-a-novel-prognostic-biomarker-associated-with-immune-infiltration-a-pancancer-analysis/332918.png","ImageObject",300,407,{"name":42,"@type":43},"Genevieve","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What is DCLRE1B, and why is it studied in cancer?","Question",{"text":63,"@type":64},"DCLRE1B is a conserved gene involved in DNA cross-link repair. Its role in tumors is unclear, so the study examines how its expression relates to cancer behavior and prognosis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was DCLRE1B expression analyzed across cancers?",{"text":68,"@type":64},"The research profiles DCLRE1B expression in tumor and normal tissues using TCGA, GTEx, and TARGET datasets, and it further verifies expression patterns using clinical melanoma samples.",{"name":70,"@type":61,"acceptedAnswer":71},"What connection does DCLRE1B have with the immune environment?",{"text":72,"@type":64},"DCLRE1B is associated with the immune landscape and multiple immune biomarkers and regulators, suggesting it may influence tumor immunity beyond DNA repair.",{"name":74,"@type":61,"acceptedAnswer":75},"Does the study suggest any therapeutic directions?",{"text":76,"@type":64},"Yes. The analysis identifies potential small molecules that could target DCLRE1B in different cancer types, supporting a basis for diagnosis and treatment exploration.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},332918,1790198092,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,115,118,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":116,"slug":117},30,"research-report",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},9,"Religion & Spirituality",20,"religion-spirituality",{"id":121,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":121,"slug":125},"World Cup","world-cup",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":127,"slug":129},10,"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":101,"slug":133},19,"General","general",{"code":4,"msg":86,"data":135},{"doc_id":83,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":143,"language":144,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":12,"update_tm":148,"read_time":113,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nDCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis  \nMi Zou1,2,10, Zuxi Feng1,10, Kaibo Hu1,2, Yuan Shu1,2, Ting Li1,2, Xiaogang Peng3, Leifeng Chen4, Leyang Xiao1,2, Shouhua Zhang5, Ting Xiong1, Xueqiang Deng6􀀍, Jie Peng1,2􀀍 & Liang Hao1,7,8,9􀀍  \nThe DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal–Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in tumour tissues and normal tissues using TCGA, GTEx, and TARGET datasets. Additionally, we performed experiments with clinical melanoma samples to verify DCLRE1B expression patterns. We also performed pancancer analyses to investigate the diverse roles of DCLRE1B in the biological functions of various cancers. DCLRE1B exhibited distinct expression patterns and played crucial prognostic roles in most tumours. In particular, high expression of DCLRE1B in melanoma was significantly correlated with a poor prognosis and increased malignancy. DCLRE1B was also found to be associated with the immune landscape and various immune biomarkers and regulators. Furthermore, our analysis identified potential small molecules that could target DCLRE1B in different cancer types. The DCLRE1B gene may be involved in the development and occurrence of a variety of cancers. Additionally, DCLRE1B affects various tumour types not only by mediating DNA repair but also by shaping the differential immune microenvironment. In conclusion, our research offers fresh perspectives on the diagnosis and treatment of different types of cancers.  \nKeywords DCLRE1B, Pancancer, Prognostic biomarker, Immunotherapy response, Prognosis  \nDNA cross-link repair 1B (DCLRE1B) is a conserved protein-coding gene that participates in cross-link repair between DNA strands1. DCLRE1B is homologous to the PSO2 gene in Saccharomyces cerevisiae2. The DCLRE1B sequence includes a protein‒protein interaction domain, a TRF2-binding domain, and a typical MBL-β-CasP domain, and it is a member of the β-CasP nucleic acid-processing nuclease subfamily. DCLRE1B belongs to the metal β amidase (MBL) structure superfamily, which includes major 5’−3’DNA repair exonucleases in humans. This nucleic acid exonuclease family has been studied relatively little. Its members include DCLRE1A and DCLRE1C3. This family plays a vital role in cellular metabolism, including gene stability and diversity, DNA damage repair responses, mitotic cell cycle checkpoints, telomere maintenance, immune system development, and protein ubiquitination3,4.  \nDCLRE1B deficiency is closely associated with Hoyeraal–Hreidarsson syndrome and congenital dyskeratosis5. The protein encoded by the DCLRE1B gene, DCLRE1B (also known as SNM1B/Apollo), is a 5’−3’ exonuclease that plays roles both in DNA damage and in relation to telomeres6. DCLRE1Bis involved in telomere maintenance and protection through its interaction with TRF2, a shelterin component, thus preventing telomeric fusion7.  \n1Department of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China. 2The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China. 3Jiangxi Province Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.  \n4Department of General Surgery, Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China. 5Department of General Surgery, Jiangxi Children’s Hospital, Nanchang 330006, Jiangxi Province, China. 6Department of Rehabilitation, Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi ","cbCaihKe4M2K7g8W","https://ap.wps.com/l/cbCaihKe4M2K7g8W","pdf",17903037,16,"English","# Introduction and background\n## Gene function and relation to DNA repair\n## Links to telomere maintenance and disease\n# Expression and validation strategy\n## Dataset-based profiling (TCGA, GTEx, TARGET)\n## Experimental verification in melanoma\n# Pan-cancer findings\n## Expression patterns and prognostic roles\n## Association with immune landscape and biomarkers\n# Translational insights\n## Candidate small-molecule targets\n## Implications for diagnosis and treatment","[{\"question\":\"What is DCLRE1B, and why is it studied in cancer?\",\"answer\":\"DCLRE1B is a conserved gene involved in DNA cross-link repair. Its role in tumors is unclear, so the study examines how its expression relates to cancer behavior and prognosis.\"},{\"question\":\"How was DCLRE1B expression analyzed across cancers?\",\"answer\":\"The research profiles DCLRE1B expression in tumor and normal tissues using TCGA, GTEx, and TARGET datasets, and it further verifies expression patterns using clinical melanoma samples.\"},{\"question\":\"What connection does DCLRE1B have with the immune environment?\",\"answer\":\"DCLRE1B is associated with the immune landscape and multiple immune biomarkers and regulators, suggesting it may influence tumor immunity beyond DNA repair.\"},{\"question\":\"Does the study suggest any therapeutic directions?\",\"answer\":\"Yes. The analysis identifies potential small molecules that could target DCLRE1B in different cancer types, supporting a basis for diagnosis and treatment exploration.\"}]","DCLRE1B as a novel prognostic biomarker associated with immune infiltration - a pancancer analysis | PDF",1789999996]