[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-329140-en":3,"doc-seo-329140-105":31,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":28,"seo_description":14,"update_tm":29,"read_time":30},329140,1099514067438,"River Wang","https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542",7,"Healthcare","Cytotoxic Effect of Phoenix dactylifera (Iraqi Date) Leaves and Fruits Extracts against Breast Cancers Cell Lines","Objective: Cancerous diseases are highlighted as highly prevalent and life threatening, driven by uncontrolled cell growth and improved by early diagnosis. This study evaluates herbal-based management of breast cancer, the second most common cancer globally. Methods: Anticancer activity of two Iraqi date palm (Phoenix dactylifera) extracts—leaves and fruits—was tested in vitro against breast cancer cell lines (AMJ13, MCF7, MDA-MB-231, CAL51) and assessed for safety on normal fibroblast (MEF). Results: Leaf extract showed strong, concentration-dependent cytotoxicity after 72 h, with inhibition strongest for AMJ13, limited effects on others, and no significant effect from the fruit extract; both extracts showed no effect on normal cells. Conclusion: Leaf extract is promising for anticancer properties, while fruit extract lacks direct anticancer activity.","RESEARCH ARTICLE  \nEditorial Process: Submission:02/26/2024 Acceptance:07/21/2024  \nCytotoxic Effect of Phoenix dactylifera (Iraqi Date) Leaves and Fruits Extracts against Breast Cancers Cell Lines  \nSaadia Saleh Mehdy AL-Zeiny1, Maeda Hussain Mohammad2, Aous Kahtan Almzaien2, Ahmed Majeed Al-Shammari2 *, Ayser Ayed Ahmed2, Hiba Karem Shaker2  \nAbstract  \nObjective: Now a day’s cancerous diseases are the most prevalent life threatening that spreading because of the lifestyle. Its due to uncontrolled growth of cell which can be cured if diagnosed in early stage. Treatment of cancer depends on the various internal and external factors causing cancer. The main objective of this study is using herbal based medicine to manage breast cancer, the second most common type of cancer in the world. Methods: In this study, the anticancer effect of two Iraqi date palm part extracts (leaves and fruits) against panel of breast cancer cell lines (AMJ13و MCF7, MDA-MB-231, CAL51) in vitro to evaluate their possible antitumor effect and their safety on normal cell line (MEF). Results: The Phoenix dactylifera (dray Zahdi) fresh leave extract showed highly cytotoxic effects in all breast cancer cell lines. The leaves extract was showed concentration dependent cytotoxicity effects after 72 h exposure time. Leave extracts was effective against AMJ13 cell line. The effective concentrations in both cancer cells ranged from 2500-20000 μg/ ml with inhibition percentage against AMJ13 was (66.7, 70.6, 53, and 54%) . While the effect against MCF7, MDA-MB, and CAL51 cell lines were less with significant effect only at two concentrations (10000-20000 μg/ ml) causing 64.3, and 64.3% growth inhibition respectively in MCF7, and 40, and 50% respectively in MDA-MB, and 44.0, and 52.0% respectively in CAL51. The dray date fruit extract has no significant cytotoxicity against all the cancer cells. Both extracts have no effect against normal fibroblast cells. Conclusion: In conclusion, Phoenix dactylifera fresh leave extract shows promising anticancer properties while the fruit extract has no direct anticancer effect.  \nKeywords: AMJ13-breast cancer-cytotoxicity-cell line-Date Palm-CAL51-MCF7-MDA-MB-231  \nAsian Pac J Cancer Prev, 25 (7), 2391-2396  \nIntroduction  \nBreast cancer is the second leading cause of cancer deaths among women in the United States and other countries. Cancer is a major public health problem in the world. Therefore, finding natural compounds from plants is an alternative cancer treatment, because chemotherapy is one of the commonly used in breast cancer treatment, but therapy is usually associated with adverse side effects, ranging from nausea to bone marrow failure and development of multidrug resistance (MDR) [1] .  \nChemotherapy (the use of chemical compounds to fight neoplastic diseases), in addition to surgery, that uses to treated effective in different types of cancers including breast, colorectal, ovarian, and lung cancer but chemotherapeutic agents face the challenge of low selectivity and toxic effects on other non-target tissue. Therefore, the use of alternative and complementary therapies such as herbal medication has bioactive compounds from plants are used to treat various diseases  \nlike [2, 3] .  \nHence, the screening of plants for anticancer effects has been actively pursued on an international scale [2] . This has led to an increased interest and active search for novel anticancer agents from natural products [3] . In chemotherapy field, around 75% of the anticancer agents used nowadays are derived from natural products of different origins, and plants are an important source of new promising therapies (Hanen et al., 2018) .  \nIn vitro cell-based assays have been developed to rapidly determine the cytotoxic activity of several compounds. Cell-based assays are also useful in identifying variations in susceptibility of different target cells to several chemotherapeutic agents [4] .  \nPhoenix dactylifera L. (date palm) is an anci","cbCaivW5Yk1RazdK","https://ap.wps.com/l/cbCaivW5Yk1RazdK","pdf",493209,13,1,6,"English","en",105,"# Abstract\n# Introduction\n## Background and rationale\n## Natural products and anticancer screening\n## In vitro cytotoxicity assays\n## Phoenix dactylifera as a medicinal plant\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What was the main objective of this study?\",\"answer\":\"To evaluate the anticancer potential of Iraqi date palm leaves and fruits extracts against breast cancer cell lines, including their safety on normal cells.\"},{\"question\":\"Which extracts showed cytotoxic effects against breast cancer cells?\",\"answer\":\"The fresh leaf extract of Phoenix dactylifera showed highly cytotoxic and concentration-dependent effects, while the fruit extract showed no significant cytotoxicity against the tested cancer cells.\"},{\"question\":\"Did the extracts affect normal fibroblast cells?\",\"answer\":\"No. Both extracts had no effect on the normal fibroblast cell line tested.\"}]","Cytotoxic Effect of Phoenix dactylifera (Iraqi Date) Leaves and Fruits Extracts against Breast Cancers Cell Lines | PDF",1789982724,15,{"code":4,"msg":32,"data":33},"ok",{"site_id":25,"language":24,"slug":34,"title":13,"keywords":35,"description":14,"schema_data":36,"social_meta":93,"head_meta":95,"extra_data":97,"updated_unix":98},"cytotoxic-effect-of-phoenix-dactylifera-iraqi-date-leaves-and-fruits-extracts-against-breast-cancers-cell-lines","",{"@graph":37,"@context":92},[38,55,75],{"@type":39,"itemListElement":40},"BreadcrumbList",[41,45,49,52],{"item":42,"name":43,"@type":44,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":46,"name":47,"@type":44,"position":48},"https://docshare.wps.com/document/","Document",2,{"item":50,"name":12,"@type":44,"position":51},"https://docshare.wps.com/document/healthcare/",3,{"item":53,"name":13,"@type":44,"position":54},"https://docshare.wps.com/document/cytotoxic-effect-of-phoenix-dactylifera-iraqi-date-leaves-and-fruits-extracts-against-breast-cancers-cell-lines/329140/",4,{"url":53,"name":13,"@type":56,"image":57,"author":62,"headline":13,"publisher":64,"fileFormat":67,"inLanguage":24,"description":14,"dateModified":68,"datePublished":69,"encodingFormat":67,"isAccessibleForFree":70,"interactionStatistic":71},"DigitalDocument",{"url":58,"@type":59,"width":60,"height":61},"https://docshare.wps.com/thumbnails/cytotoxic-effect-of-phoenix-dactylifera-iraqi-date-leaves-and-fruits-extracts-against-breast-cancers-cell-lines/329140.png","ImageObject",300,407,{"name":9,"@type":63},"Person",{"url":42,"name":65,"@type":66},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":72,"interactionType":73,"userInteractionCount":20},"InteractionCounter",{"@type":74},"ViewAction",{"@type":76,"mainEntity":77},"FAQPage",[78,84,88],{"name":79,"@type":80,"acceptedAnswer":81},"What was the main objective of this study?","Question",{"text":82,"@type":83},"To evaluate the anticancer potential of Iraqi date palm leaves and fruits extracts against breast cancer cell lines, including their safety on normal cells.","Answer",{"name":85,"@type":80,"acceptedAnswer":86},"Which extracts showed cytotoxic effects against breast cancer cells?",{"text":87,"@type":83},"The fresh leaf extract of Phoenix dactylifera showed highly cytotoxic and concentration-dependent effects, while the fruit extract showed no significant cytotoxicity against the tested cancer cells.",{"name":89,"@type":80,"acceptedAnswer":90},"Did the extracts affect normal fibroblast cells?",{"text":91,"@type":83},"No. Both extracts had no effect on the normal fibroblast cell line tested.","https://schema.org",{"og:url":53,"og:type":94,"og:title":13,"og:site_name":65,"og:description":14},"article",{"robots":96,"canonical":53},"index,follow",{"doc_id":7,"site_id":25},1790049295,{"code":4,"msg":5,"data":100},[101,105,109,113,118,122,125,130,135,138,142],{"id":21,"doc_module":4,"doc_module_name":47,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":48,"doc_module":4,"doc_module_name":47,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":54,"doc_module":4,"doc_module_name":47,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":47,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":22,"doc_module":4,"doc_module_name":47,"category_name":119,"show_sort_weight":120,"slug":121},"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":47,"category_name":12,"show_sort_weight":123,"slug":124},40,"healthcare",{"id":126,"doc_module":4,"doc_module_name":47,"category_name":127,"show_sort_weight":128,"slug":129},8,"Research & Report",30,"research-report",{"id":131,"doc_module":4,"doc_module_name":47,"category_name":132,"show_sort_weight":133,"slug":134},9,"Religion & Spirituality",20,"religion-spirituality",{"id":133,"doc_module":4,"doc_module_name":47,"category_name":136,"show_sort_weight":133,"slug":137},"World Cup","world-cup",{"id":139,"doc_module":4,"doc_module_name":47,"category_name":140,"show_sort_weight":139,"slug":141},10,"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":47,"category_name":144,"show_sort_weight":114,"slug":145},19,"General","general"]