[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-427810-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-427810-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","cytomegalovirus-midlife-inflammation-and-subclinical-cardiovascular-disease-the-swan-study","CYTOMEGALOVIRUS, MIDLIFE INFLAMMATION, AND SUBCLINICAL CARDIOVASCULAR DISEASE: THE SWAN STUDY","","Cytomegalovirus (CMV) is a common beta herpesvirus that persists latently after often asymptomatic infection. In the Michigan SWAN cohort, CMV seropositivity was related to inflammatory marker C-reactive protein and carotid intima media thickness (cIMT) in 100 pre- or peri-menopausal women assessed roughly 10 years later. Latent CMV (IgG+ IgM-) showed higher seropositivity in Black than White women, higher CRP, and greater future subclinical cardiovascular risk with larger cIMT measures across groups.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cytomegalovirus-midlife-inflammation-and-subclinical-cardiovascular-disease-the-swan-study/427810/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cytomegalovirus-midlife-inflammation-and-subclinical-cardiovascular-disease-the-swan-study/427810.png","ImageObject",300,407,{"name":42,"@type":43},"Alex Sinclair","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-14","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How is latent CMV infection defined in this study?","Question",{"text":63,"@type":64},"Latent CMV seropositivity is defined as IgG positive and IgM negative.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What inflammatory marker and cardiovascular measure were analyzed?",{"text":68,"@type":64},"The study examined C-reactive protein (CRP) and carotid intima media thickness (cIMT).",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about CMV seropositivity and later cardiovascular risk?",{"text":72,"@type":64},"Women with CMV seropositivity had higher CRP levels and worse cIMT outcomes (larger average and maximal cIMT), suggesting greater inflammation and subclinical cardiovascular risk.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},427810,1790705150,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":26,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":97},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Innovation in Aging, 2025, Vol. 9, No. S2 875  \nAbstract citation ID: igaf122.2961  \nCYTOMEGALOVIRUS, MIDLIFE INFLAMMATION, AND SUBCLINICAL CARDIOVASCULAR DISEASE: THE SWAN STUDY  \nAleda Leis1, Michelle Hood2, Wade Sanders1, Laura McLees1, and Carrie Karvonen-Gutierrez1, 1. University of Michigan, Ann Arbor, Michigan, United States, 2. University of Michigan School of Public Health, Ann Arbor, Michigan, United States  \nCytomegalovirus (CMV) is a common beta herpesvirus with over half of US adults infected by age 40. Following an often asymptomatic acute infection, the virus remains latent with the potential for reactivation across the lifecourse. We examined associations of CMV seropositivity with the inflammatory marker c-reactive protein and carotid intima media thickness (cIMT) in the Michigan site of the Study of Women’s Health Across the Nation (SWAN) . Qualitative serum CMV immunoglobulin G (IgG) and M (IgM) assays were conducted in 100 pre- or peri-menopausal women (50 White, 50 Black, mean age 48.3 years) with carotid artery ultrasounds approximately 10 years later. Latent CMV seropositivity was defined as being IgG positive and IgM negative. Overall, 61% of samples were seropositive for latent CMV infection, with higher CMV seropositivity in Black (78%) than White (44%) women. Those with latent CMV seropositivity had almost two times higher C-reactive protein levels those without (8.7mg/L (standard deviation (SD):14.4) vs. 4.6mg/L (SD:4 .7)). Latent CMV seropositivity was  \n876 Innovation in Aging, 2025, Vol. 9, No. S2  \nassociated with future subclinical cardiovascular risk. Those with CMV seropositivity had larger (worse) average carotid intima media thickness (cIMT) (mean 0. 86mm (SD:0 . 12) vs. 0.76mm  \n(SD:0.10); p \u003C 0.001) and maximal cIMT (mean 1.01mm  \n(SD:0.14) vs. 0.90mm (SD:0.1); p \u003C 0.001) compared to those who were not CMV seropositive. Results were similar when stratified by race. Together, the results suggest CMV seropositivity may be associated with greater inflammation and cardiovascular risk as women enter older adulthood.","cbCaidVlXJxBG05H","https://ap.wps.com/l/cbCaidVlXJxBG05H","pdf",65636,"English","# Abstract\n## Study cohort and design\n## CMV definitions and laboratory assays\n## Inflammatory and cardiovascular outcomes\n## Conclusions","[{\"question\":\"How is latent CMV infection defined in this study?\",\"answer\":\"Latent CMV seropositivity is defined as IgG positive and IgM negative.\"},{\"question\":\"What inflammatory marker and cardiovascular measure were analyzed?\",\"answer\":\"The study examined C-reactive protein (CRP) and carotid intima media thickness (cIMT).\"},{\"question\":\"What did the results show about CMV seropositivity and later cardiovascular risk?\",\"answer\":\"Women with CMV seropositivity had higher CRP levels and worse cIMT outcomes (larger average and maximal cIMT), suggesting greater inflammation and subclinical cardiovascular risk.\"}]","CYTOMEGALOVIRUS, MIDLIFE INFLAMMATION, AND SUBCLINICAL CARDIOVASCULAR DISEASE: THE SWAN STUDY | PDF",1790644854]