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The study evaluates CXCL14, atypical chemokine receptor 2 (ACKR2), and epithelial–mesenchymal transition (EMT) markers using TCGA/GEO analyses and multiple biochemical and imaging assays. Functional migration and wound-healing experiments, including an orthotopic metastasis model, show ACKR2-dependent signaling involving PLCβ3, PKCα, and c-Src that activates NF-κB, driving EMT and cell motility, supporting CXCL14/ACKR2 as a metastasis-related prognostic biomarker.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cxcl14-promotes-metastasis-of-non-small-cell-lung-cancer-through-ackr2-depended-signaling-pathway/385688/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cxcl14-promotes-metastasis-of-non-small-cell-lung-cancer-through-ackr2-depended-signaling-pathway/385688.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main aim of this study on CXCL14 in lung cancer?","Question",{"text":112,"@type":113},"To determine the mechanism by which CXCL14 promotes cancer metastasis, including the role of its specific receptor in lung cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which receptor and downstream signaling pathway are implicated in CXCL14-driven metastasis?",{"text":117,"@type":113},"ACKR2 is identified as a key mediator; CXCL14 triggers PLCβ3, PKCα, and c-Src signaling, which increases NF-κB transcription activity and leads to EMT and migration.",{"name":119,"@type":110,"acceptedAnswer":120},"How do the authors evaluate metastasis and cancer cell migration?",{"text":121,"@type":113},"They assess migration using in vitro assays including migration and wound healing experiments, and they evaluate metastasis using an orthotopic model.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},385688,1790661632,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Ivyspring  \nInternational Publisher  \nInternationalJournal of Biological Sciences  \n2023; 19(5): 1455-1470. doi: 10.7150/ijbs.79438  \nResearch Paper  \nCXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway  \nTsung-Ming Chang1, Yao-Chang Chiang2,3, Chiang-Wen Lee2,3,4,5, Chieh-Mo Lin2,6,7, Mei-Ling Fang8,9, Miao-Ching Chi2,4,6,10􀀍, Ju-Fang Liu11, 12, 13􀀍, Yu Ru Kou1,14􀀍  \n1. Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.  \n2. Department of Nursing, Division of Basic Medical Sciences, and Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan.  \n3. Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan.  \n4. Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.  \n5. Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.  \n6. Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.  \n7. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.  \n8. Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, Taiwan.  \n9. Super Micro Research and Technology Center, Cheng Shiu University, Kaohsiung 83347, Taiwan.  \n10. Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan.  \n11. School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.  \n12. Translational Medicine Center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan.  \n13. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.  \n14. Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan.  \n􀀍 Corresponding authors: Miao-Ching Chi, Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan. Tel:  \n(886) 5-3628800 ext. 2239, [E-mail: mcchi@ mail.cgust.edu.tw or Ju-Fang Liu](E-mail: mcchi@ mail.cgust.edu.tw or Ju-Fang Liu), School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan. Tel: (886) 2-8332211 ext. 9420, [E-mail: jufangliu@tmu.edu.tw or Yu Ru Kou](E-mail: jufangliu@tmu.edu.tw or Yu Ru Kou), Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan. Tel: (886) 3-8561825 ext. 15933, [E-mail: yrkou@nycu.edu.tw](E-mail: yrkou@nycu.edu.tw).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2022.09.30; Accepted: 2023.02.12; Published: 2023.02.27  \nAbstract  \nBackground: Lung cancer is a malignant tumor with metastatic potential. Chemokine ligand 14 (CXCL14) has been reported to be associated with different cancer cell migration and invasion. However, few studies have explored the function of CXCL14 and its specific receptor in lung cancer metastasis. This study aims to determine the mechanism of CXCL14-promoted cancer metastasis.  \nMethods: The expression of CXCL14, atypical chemokine receptor 2 (ACKR2), and epithelial mesenchymal transition (EMT) markers was evaluated by the public database of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), Western blot, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qPCR), immunohistochemistry (IHC), and immunoflu","cbCaid4hiTIlRTFd","https://ap.wps.com/l/cbCaid4hiTIlRTFd","pdf",10542653,16,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Keywords\n# Introduction","[{\"question\":\"What is the main aim of this study on CXCL14 in lung cancer?\",\"answer\":\"To determine the mechanism by which CXCL14 promotes cancer metastasis, including the role of its specific receptor in lung cancer.\"},{\"question\":\"Which receptor and downstream signaling pathway are implicated in CXCL14-driven metastasis?\",\"answer\":\"ACKR2 is identified as a key mediator; CXCL14 triggers PLCβ3, PKCα, and c-Src signaling, which increases NF-κB transcription activity and leads to EMT and migration.\"},{\"question\":\"How do the authors evaluate metastasis and cancer cell migration?\",\"answer\":\"They assess migration using in vitro assays including migration and wound healing experiments, and they evaluate metastasis using an orthotopic model.\"}]","CXCL14 promotes metastasis of non-small cell lung cancer through ACKR2-depended signaling pathway | PDF",1790270575]