[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370564-105":59,"doc-detail-370564-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cutaneous-metastases-histological-particularities-of-multifaceted-entities","Cutaneous Metastases - Histological Particularities of Multifaceted Entities","","Cutaneous metastases from internal-organ cancers are diagnosed in about 0.2% of skin biopsies and may represent the first evidence of an otherwise undetected malignancy originating from deep organs. A retrospective review of all cutaneous metastasis cases at a single hospital identified 25 patients (14 females, 11 males; mean age 62.3). The study reports different most common primary sites by sex, notes anterior thoracic wall, abdomen, and scalp involvement, and emphasizes the histopathologic recognition and immunohistochemistry for reliable differentiation from primary skin neoplasms.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cutaneous-metastases-histological-particularities-of-multifaceted-entities/370564/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cutaneous-metastases-histological-particularities-of-multifaceted-entities/370564.png","ImageObject",300,407,{"name":92,"@type":93},"Alex Sinclair","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How common are cutaneous metastases in skin biopsies?","Question",{"text":112,"@type":113},"Cutaneous metastases from internal-organ cancers are diagnosed in approximately 0.2% of skin biopsies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Can skin metastases be the first sign of cancer?",{"text":117,"@type":113},"Yes. In the study, cutaneous metastases were the first sign of an internal-organ cancer in seven cases.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is immunohistochemistry important for diagnosis?",{"text":121,"@type":113},"Immunohistochemistry is considered mandatory for differential diagnosis, especially when patients do not have a prior history of neoplasia.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},370564,1790419826,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Article  \nCutaneous Metastases—Histological Particularities of Multifaceted Entities  \nAndreea Cătălina Tinca 1,2, Bianca Andreea Lazar 2,*, Andreea Raluca Cozac-Sz ˝oke 1,2, Georgian Nicolae Radu 2,  \nSimina Petra Simion 2, Diana Maria Chiorean 1,2, Irina Bianca Kosovski 1, Adrian Horaiu Sabău 1,2, Raluca Niculescu 1,2, Iuliu Gabriel Cocuz 1,2, Raluca-Diana Hagău 2, Emoke Andrea Szasz 2, Sabin Gligore Turdean 2 and Ovidiu Simion Cotoi 1,2  \n1 Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology,  \n540142 Târgu-Mures,, Romania; [andreea-catalina.tinca@umfst.ro](andreea-catalina.tinca@umfst.ro) (A.C.T.); [andreea-raluca.szoke@umfst.ro](andreea-raluca.szoke@umfst.ro) (A.R.C.-S.); [diana.chiorean@umfst.ro](diana.chiorean@umfst.ro) (D.M.C.);  \n[bianca.kosovski@umfst.ro](bianca.kosovski@umfst.ro) (I.B.K.); [adrian-horatiu.sabau@umfst.ro](adrian-horatiu.sabau@umfst.ro) (A.H.S.); [raluca.niculescu@umfst.ro](raluca.niculescu@umfst.ro) (R.N.);  \n[iuliu.cocuz@umfst.ro](iuliu.cocuz@umfst.ro) (I.G.C.); [ovidiu.cotoi@umfst.ro](ovidiu.cotoi@umfst.ro) (O.S.C.)  \n2 Pathology Department, Mures, Clinical County Hospital, 540003 Târgu Mures,, Romania; [george.radu098@gmail.com](george.radu098@gmail.com) (G.N.R.); [simionsimina70@yahoo.ro](simionsimina70@yahoo.ro) (S.P.S.);  \n[ralucahagau1995@gmail.com](ralucahagau1995@gmail.com) (R.-D.H.); [emoke.szasz@umfst.ro](emoke.szasz@umfst.ro) (E.A.S.); [sabin.turdean@umfst.ro](sabin.turdean@umfst.ro) (S.G.T.)  \n* Correspondence: [ohii.bianca@yahoo.com](ohii.bianca@yahoo.com)  \nAcademic Editor: Gürkan Kaya  \nReceived: 13 March 2025  \nRevised: 18 April 2025  \nAccepted: 24 April 2025  \nPublished: 25 April 2025  \nCitation: Tinca, A.C.; Lazar, B.A.; Cozac-Sz˝oke, A.R.; Radu, G.N.; Simion, S.P.; Chiorean, D.M.; Kosovski, I.B.; Sabău, A.H.; Niculescu, R.; Cocuz, I.G.; et al. Cutaneous Metastases—Histological Particularities of Multifaceted Entities. Dermatopathology 2025, 12, 14 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)dermatopathology12020014  \nCopyright: © 2025 by the authors. Published by MDPI on behalf of the European Society of Dermatopathology. LicenseeMDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons](https://creativecommons). org/licenses/by/4.0/) .  \nAbstract: Cutaneous metastases from internal organ cancers are diagnosed in approximately 0.2% of skin biopsies. This diagnosis can be the first sign of a previously undiagnosed malignancy with an internal organ origin. We conducted a retrospective study that included all cases of cutaneous metastases diagnosed in our hospital. A total of 25 patients were identified (14 females and 11 males) . The average age of the patients included was 62.3 . The most common primary cancer site was the lung for male patients, while for female patients it was the breast. In seven of our cases, cutaneous metastases were the first sign of an internal organ cancer. Common sites for cutaneous metastases in our study involved the anterior thoracic wall, the abdomen, and the scalp. Our study aims to highlight the importance of recognizing the histopathology of metastatic tumors and differentiating them from primary skin neoplasms. Immunohistochemistry is a mandatory tool for differential diagnosis in all cases, especially for patients who do not have a history of neoplasia.  \nKeywords: cutaneous metastases; cancers; immunohistochemistry  \n1. Introduction  \nThe skin is the largest organ of the human body and is important for protecting internal structures, temperature regulation, sensory information, and contributing to maintaining the overall homeostasis [1] . The skin also serves as a site for the manifestation of systemic conditions for which specific and non-specific histopathological characteristics can be identified [2–4] .  \nSkin neoplasias, both ","cbCaigvofM74poIp","https://ap.wps.com/l/cbCaigvofM74poIp","pdf",7684571,14,"English","# Introduction\n## Classification of cutaneous metastases\n## Clinical significance and prognostic context","[{\"question\":\"How common are cutaneous metastases in skin biopsies?\",\"answer\":\"Cutaneous metastases from internal-organ cancers are diagnosed in approximately 0.2% of skin biopsies.\"},{\"question\":\"Can skin metastases be the first sign of cancer?\",\"answer\":\"Yes. In the study, cutaneous metastases were the first sign of an internal-organ cancer in seven cases.\"},{\"question\":\"Why is immunohistochemistry important for diagnosis?\",\"answer\":\"Immunohistochemistry is considered mandatory for differential diagnosis, especially when patients do not have a prior history of neoplasia.\"}]","Cutaneous Metastases - Histological Particularities of Multifaceted Entities | PDF",1790189181,35]