[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443212-105":59,"doc-detail-443212-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cutaneous-iga-vasculitis-triggered-by-acetaminophen","Cutaneous IgA vasculitis triggered by acetaminophen","","Cutaneous IgA vasculitis is presented as a rare but clinically important adverse reaction to acetaminophen. A 61-year-old woman developed pruritic, painful purpuric lesions across the face and extremities, which worsened with scratching; the rash began about two months earlier and improved after discontinuing acetaminophen. Laboratory tests showed elevated inflammatory markers with normal renal function. Skin biopsies demonstrated leukocytoclastic vasculitis with granular IgA deposition on immunofluorescence. Symptoms improved with avoidance alone, and she was advised ongoing renal monitoring.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cutaneous-iga-vasculitis-triggered-by-acetaminophen/443212/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cutaneous-iga-vasculitis-triggered-by-acetaminophen/443212.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is IgA vasculitis (IgAV) and what organs does it commonly affect?","Question",{"text":112,"@type":113},"IgAV is a systemic vasculitis due to immune-complex deposition in small vessels, primarily involving joints, kidneys, skin, and the gastrointestinal tract. Common features include palpable purpura and potential nephritis and GI symptoms depending on severity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the patient’s symptoms change in relation to acetaminophen use?",{"text":117,"@type":113},"The patient managed arthritic pain with acetaminophen, and her rash began about two months before presentation. After stopping acetaminophen, the eruption started clearing and she reported significant improvement at follow-up.",{"name":119,"@type":110,"acceptedAnswer":120},"What confirmed the diagnosis in this case?",{"text":121,"@type":113},"Two skin punch biopsies from the pretibial region showed leukocytoclastic vasculitis with superficial perivascular lymphocytic infiltrates, neutrophils, and fibrinoid degeneration. Immunofluorescence confirmed granular IgA deposition in dermal blood vessels.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},443212,1791107086,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","CASE REPORT  \nCutaneous IgA vasculitis triggered by acetaminophen  \nJose Gaspar de Alba, BA,a Aaron Cheng, BA, BS,a Cadfael Soulard, BA,a Emily Ames, BBA,b and  \nVictoria G. Farley, MDb ,c  \nKey words: acetaminophen; adult-onset; conservative treatment; IgA vasculitis.  \nINTRODUCTION  \nImmunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schoenlein purpura, is a systemic vasculitis caused by immune-complex deposition in small vessels, primarily affecting the joints, kidneys, skin, and gastrointestinal tract.1 Common symptoms include diffuse palpable purpura, nausea, vomiting, arthralgias, and nephritis, depending on the severity of disease.1 Histologically, IgAV is considered a subtype of leukocytoclastic vasculitis due to its characteristic neutrophil-predominant perivascular infiltrates and fibrinoid vessel wall destruction.2 While IgAV may be idiopathic, it frequently follows an upper respiratory tract infection.1 Other triggers include neoplasms, autoimmune diseases, vaccines, and medications such as antibiotics and tumor necrosis factor-a blockers.1 Rarely, IgAVis associated with over-the-counter analgesics.3 Herein, we report the second known case of acetaminophen-induced IgAV.  \nCASE REPORT  \nA 61-year-old Caucasian female presented with pruritic and painful purpuric lesions on her right cheek, right zygoma, inferior forehead, right upper back, left forearm, and right pretibial region, which worsened with scratching (Fig 1, A and B) . The patient has a history of type 2 diabetes mellitus and arthritic pain, which she managed with acetaminophen. She reported that the rash began 2 months prior and had been spreading, but it had started to clear since stopping acetaminophen.  \nFrom the Long School of Medicine, University of Texas Health San Antonio, San Antonio, Texasa; Kirk Kerkorian School of Medicine at UNLV, Las Vegas, Nevadab; and Vivida Dermatology, Las  \nVegas, Nevada.c Funding sources: None.  \nPatient consent: The authors obtained written consent from the patient for their photographs and medical information to be published in print and online and with the understanding that this information may be publicly available. Patient consent forms were not provided to the journal but are retained by the authors.  \nAbbreviations used:  \nANCA: antineutrophil cytoplasmic antibody  \nCRP: C-reactive protein  \nESR: erythrocyte sedimentation rate GPA: granulomatosis with polyangiitis  \nIgAV: immunoglobulin A vasculitis  \nLCV: leukocytoclastic vasculitis  \nMPA: microscopic polyangiitis  \nPAN: polyarteritis nodosa  \nFig 1. A, Clinical picture of palpable purpura with necrotic centers on the patients right lower extremity and (B), patients left forearm.  \nPhysical exam revealed palpable purpura with necrotic centers predominantly on the right lower extremity, suggestive of several different pathologies. Considerations for the differential diagnosis could include microscopic polyangiitis or a nonspecific  \nIRB approval status: Not applicable.  \nCorrespondence to: Victoria G. Farley, MD, Vivida Dermatology, 2110 E Flamingo Rd, Suite 216, Las Vegas, NV 89119. E-mail: [VFarley@vivida.com](VFarley@vivida.com).  \nJAAD Case Reports 2026;67:194-6 .  \n2352-5126  \n© 2025 The Author(s) . Published by Elsevier Inc. on behalf of the American Academy of Dermatology, Inc. This is an open access article under the CC BY license ([http://creativecommons.org/](http://creativecommons.org/)[ ](http://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n[https://doi.org/10.1016/j.jdcr.2025.09.046](https://doi.org/10.1016/j.jdcr.2025.09.046)  \nJAAD CASE REPORTS Gaspar de Alba et al 195  \nVOLUME 67  \nFig 2. A-D, Histopathology depicting superficial perivascular lymphocytic infiltrates, neutrophils, and fibrinoid degeneration.  \nsmall-vessel vasculitis, which may be drug-induced, infection-related, or idiopathic.  \nThe patient had initially been referred to hematology by her primary care provider but had not yet had an appointment. Laborat","cbCait0kLE3fRwwg","https://ap.wps.com/l/cbCait0kLE3fRwwg","pdf",3682353,"English","# Introduction\n# Case report\n## Presentation and history\n## Evaluation and biopsy findings\n## Management and follow-up\n# Discussion","[{\"question\":\"What is IgA vasculitis (IgAV) and what organs does it commonly affect?\",\"answer\":\"IgAV is a systemic vasculitis due to immune-complex deposition in small vessels, primarily involving joints, kidneys, skin, and the gastrointestinal tract. Common features include palpable purpura and potential nephritis and GI symptoms depending on severity.\"},{\"question\":\"How did the patient’s symptoms change in relation to acetaminophen use?\",\"answer\":\"The patient managed arthritic pain with acetaminophen, and her rash began about two months before presentation. After stopping acetaminophen, the eruption started clearing and she reported significant improvement at follow-up.\"},{\"question\":\"What confirmed the diagnosis in this case?\",\"answer\":\"Two skin punch biopsies from the pretibial region showed leukocytoclastic vasculitis with superficial perivascular lymphocytic infiltrates, neutrophils, and fibrinoid degeneration. Immunofluorescence confirmed granular IgA deposition in dermal blood vessels.\"}]","Cutaneous IgA vasculitis triggered by acetaminophen | PDF",1790703312]