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Over recent decades it has gained advantages in safety, efficiency, feasibility, and cost-effectiveness. An up-to-date review of cryosurgery applications is limited, prompting this review to summarize principles and current dermatology practice.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cutaneous-cryosurgery-in-dermatology-evolving-principles-and-clinical-applications-for-benign-premalignant-and-malignant-lesions/368271/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cutaneous-cryosurgery-in-dermatology-evolving-principles-and-clinical-applications-for-benign-premalignant-and-malignant-lesions/368271.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",16,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is cryosurgery used for in dermatology?","Question",{"text":63,"@type":64},"Cryosurgery is used to treat a broad range of benign, premalignant, and malignant cutaneous conditions, either as a standalone therapy or an adjunct to other treatments.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What advantages are associated with cryosurgery?",{"text":68,"@type":64},"Cryosurgery is described as offering distinct advantages for dermatologic care, including safety, efficiency, feasibility, and cost-effectiveness.",{"name":70,"@type":61,"acceptedAnswer":71},"Why does the review emphasize the need for up-to-date information?",{"text":72,"@type":64},"A comprehensive, current review of cryosurgery applications is reported to be lacking, which limits research dissemination and recognition among 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Applications for Benign, Premalignant, and Malignant Lesions  \nRAMIA MOKBEL1, ALEVTINA KODRESKO2, KEFAH MOKBEL3, HEBA GHAZAL4, JON TREMBLEY5 and HUSSAM JOUHARA2,6 1The Princess Grace Hospital, Part of HCA Healthcare UK, London, U. K.;  \n2 Heat Pipe and Thermal Management Research Group, College of Engineering, Design and Physical Sciences, Brunel University, London, U. K.;  \n3The London Breast Institute, Princess Grace Hospital, London, U. K.;  \n4School of Pharmacy and Chemistry, Kingston University, Kingston Upon Thames, U. K.;  \n5Air Products PLC, Hersham Place Technology Park, Surrey, U. K.; 6Vytautas Magnus University, Akademija, Kaunas, Lithuania  \nAbstract  \nSkin and subcutaneous diseases represent a significant public health burden, profoundly impacting quality of life, social interactions, mental health, and daily activities–raising concerns worldwide. In modern cryogenics, cryosurgery is among the therapeutic approaches employed by healthcare professionals to address this broad and complex range of diseases. Over the past four decades, cryosurgery has evolved into a valuable treatment option, used alone or asan adjunct therapy, and is adaptable to the needs of various special populations. This approach offers distinct advantages over established treatments due to its safety, efficiency, feasibility, and cost‑effectiveness. However, a comprehensive, up‑to‑date review ofcryosurgery’s applications is lacking, which limits research dissemination and recognition among dermatologists. This review aims to provide an overview ofcryosurgery principles and its current clinical practice in dermatology, covering a broad range of benign, premalignant, and malignant cutaneous conditions, and highlighting its potential as an essential approach in global healthcare.  \nKeywords: Cryoablation, cryogenics, cryosurgery, cryotherapy, dermatology, liquid nitrogen, skin diseases, skin lesions, treatment, review.  \n✉  \nHussam Jouhara, Heat Pipe and Thermal Management Research Group, College of Engineering, Design and Physical Sciences, Brunel University, London, U.K. Tel: +44 1895267805, e‑[mail: hussam.jouhara@brunel.ac.uk](mail: hussam.jouhara@brunel.ac.uk)  \nReceived December 28, 2024 | Revised January 11, 2025 | Accepted January 13, 2025  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n©2025 The Author(s) . Anticancer Research is published by the International Institute of Anticancer Research.  \nIntroduction  \nSkin and subcutaneous diseases represent a significant public health burden worldwide, with prevalence rising continuously–most notably by 47% between 1990 and 2017 (1). According to data from the Global Burden of Disease (GBD) study, skin diseases rank as the 18th leading cause of disability‑adjusted life years (DALYs) and the 4th leading cause of disability globally. Excluding mortality, the years lived with disability (YLDs) from skin diseases exceed those caused by diabetes mellitus (36.4 million vs. 29.5 million). Research consistently highlights the profound impact of these conditions on quality of life, social interactions, mental health, and daily activities (2). A recent study by Kanji (3) on common chronic dermatological conditions–such as eczema, psoriasis, acne, rosacea, vitiligo, seborrhoeic dermatitis, and skin allergy–identified key aspects of daily life affected, with stress levels and mood being the most frequently impacted, as shown in Figure 1. These findings reinforce substantial research linking the onset or worsening of various skin diseases to stress, which severely impacts patients’ psychological and physical well‑being. Stress is considered a major factor in up to 85% of dermatological patients, influencing both the incidence and progression of s","cbCaib6tBklxsAsB","https://ap.wps.com/l/cbCaib6tBklxsAsB","pdf",4405408,36,"English","# Introduction\n## Public health burden of skin diseases\n## Psychological impact and stress mechanisms\n# Cryosurgery in dermatology (overview)\n## Principles and therapeutic role\n## Current clinical applications","[{\"question\":\"What is cryosurgery used for in dermatology?\",\"answer\":\"Cryosurgery is used to treat a broad range of benign, premalignant, and malignant cutaneous conditions, either as a standalone therapy or an adjunct to other treatments.\"},{\"question\":\"What advantages are associated with cryosurgery?\",\"answer\":\"Cryosurgery is described as offering distinct advantages for dermatologic care, including safety, efficiency, feasibility, and cost-effectiveness.\"},{\"question\":\"Why does the review emphasize the need for up-to-date information?\",\"answer\":\"A comprehensive, current review of cryosurgery applications is reported to be lacking, which limits research dissemination and recognition among dermatologists.\"}]","Cutaneous Cryosurgery in Dermatology - Evolving Principles and Clinical Applications for Benign, Premalignant, and Malignant Lesions | PDF",1790175969,91]