[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-361964-105":59,"doc-detail-361964-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","current-trends-in-breast-cancer-genetics-risk-factors-and-screening-strategies","Current trends in breast cancer genetics, risk factors, and screening strategies","","Breast cancer is the most commonly diagnosed female malignancy worldwide and remains a leading cause of cancer-related mortality, driving growing interest in earlier detection and prevention. This review examines the genetic landscape of breast cancer, the contribution of modifiable and non-modifiable risk factors to disease development, and the value of improved diagnostic approaches for early detection. A comprehensive search of peer-reviewed articles and clinical studies identifies key genetic predispositions, hormonal influences, lifestyle and reproductive factors. Conclusions synthesize current knowledge to inform future screening and preventive research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/current-trends-in-breast-cancer-genetics-risk-factors-and-screening-strategies/361964/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/current-trends-in-breast-cancer-genetics-risk-factors-and-screening-strategies/361964.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the main focuses of this review on breast cancer?","Question",{"text":112,"@type":113},"The review covers the genetic landscape of breast cancer, the role of risk factors in disease development, and the importance of advancing diagnostic modalities for early detection.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which types of risk factors are discussed?",{"text":117,"@type":113},"It identifies both modifiable and non-modifiable risk factors, including genetic predispositions such as BRCA mutations, hormonal influences, lifestyle factors, and reproductive patterns.",{"name":119,"@type":110,"acceptedAnswer":120},"How were the included studies selected?",{"text":121,"@type":113},"Studies were included when they addressed relationships among risk factors, genetics, and breast cancer, and also screening modalities, with accessible full texts and comprehensive data; non-peer-reviewed items and studies with incomplete or ethically concerning data were excluded.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},361964,1790198110,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","| Review |\n| --- |\n|  |\n\nCurrent trends in breast cancer genetics, risk factors, and screening strategies  \nSorana Caterina Anton1†, Alexandra Lazan1†, Mihaela Grigore1, Ciprian Ilea1, Șadiye-Ioana Scripcariu1, Setalia Popa2, Simona Volovăț3, Bogdan Doroftei1, Delia Nicolaiciuc4†*, Diana Popovici1, Gabriel Costăchescu1,  \nOvidiu Sebastian Nicolaiciuc5, and Emil Anton1†  \n1Department of Obstetrics and Gynecology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa,” Iași 700115, Romania 2Department of Medical Genetics, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa,” Iași 700115, Romania 3Department of Medical Oncology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa,” Iași 700115, Romania 4Department of Preventive Medicine and Interdisciplinarity, Faculty of Medicine, University of Medicine and Pharmacy  \n“Grigore T. Popa,” Iași 700115, Romania  \n5Department of Implantology, Removable Restorations, and Technology, Faculty of Dental Medicine, University of Medicine and Pharmacy “Grigore T. Popa,” Iași 700115, Romania  \n†These authors contributed equally to this work.  \nAbstract  \nBackground: Breast cancer is the most frequently diagnosed female malignancy worldwide and one of the primary causes of cancer-related mortality in women. According to the latest the World Health Organization data, it was the most common cancer in 157 out of 185 countries and was culpable for an estimated 670,000 deaths in 2023. With breast cancer incidence continuing to increase, there is a mounting interest in early detection and prevention, with a focus particularly directed on genetic factors, modifiable risk factors, and screening methods. Objective: This review aimed to examine the genetic landscape of breast cancer, the role of risk factors in disease development, and the importance of advancing diagnostic modalities for early detection. A comprehensive search and analysis of peer-reviewed articles and clinical studies from major medical databases were conducted to assess the most recent advancements and discoveries in the field. The literature review identified several modifiable and non-modifiable risk factors, including genetic predispositions (e.g., BRCA mutations), hormonal influences, lifestyle factors, and reproductive patterns. Conclusion: By synthesizing current knowledge, this review enhances the understanding of breast cancer’s multifactorial nature and provides insights to guide future research on screening strategies and preventive measures.  \nKeywords: Breast cancer, Breast cancer screening, Risk factors, Breast genetics, Prognostic markers  \n1. Introduction  \nCarcinogenesis has the potential to occur in every cell, tissue, and organ, resulting in pathological changes that give rise to an extensive array of malignancies. The primary mechanisms driving its progression include metastasis, unlimited proliferative capacity, enhanced angiogenesis, induction of self-sustaining growth signals, resistance to growth-inhibitory signals, and evasion of apoptosis.1 Breast cancer represents the most common cancer among women across the globe, accounting for 11.7% of all cancers worldwide in 2020.2 Over the past two decades, its incidence has increased significantly, especially in low- and middle-income countries, although the absolute incidence remains lower than in high-income countries.3,4 In the United States, the incidence of breast cancer is rising by approximately 0.6%/year.5 In 2020, virtually 685,000 global deaths were attributed to breast cancer.1,6  \nA systematic literature search was conducted using the following keywords: “Breast cancer,” “Breast cancer screening,”“Risk factors,”“Breast genetics,”and“Prognostic.”  \n*Corresponding author:  \nDelia Nicolaiciuc ([delia.nicolaiciuc@umfiasi.ro](delia.nicolaiciuc@umfiasi.ro))  \n© 2025Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 I","cbCaid1xchBKoRFB","https://ap.wps.com/l/cbCaid1xchBKoRFB","pdf",1579099,15,"English","# Abstract\n# 1. Introduction\n# Methods\n# Results and Discussion\n## Risk factors and genetic predispositions\n## Screening strategies\n# Conclusion","[{\"question\":\"What are the main focuses of this review on breast cancer?\",\"answer\":\"The review covers the genetic landscape of breast cancer, the role of risk factors in disease development, and the importance of advancing diagnostic modalities for early detection.\"},{\"question\":\"Which types of risk factors are discussed?\",\"answer\":\"It identifies both modifiable and non-modifiable risk factors, including genetic predispositions such as BRCA mutations, hormonal influences, lifestyle factors, and reproductive patterns.\"},{\"question\":\"How were the included studies selected?\",\"answer\":\"Studies were included when they addressed relationships among risk factors, genetics, and breast cancer, and also screening modalities, with accessible full texts and comprehensive data; non-peer-reviewed items and studies with incomplete or ethically concerning data were excluded.\"}]","Current trends in breast cancer genetics, risk factors, and screening strategies | PDF",1790146144,38]