[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382986-105":59,"doc-detail-382986-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","current-status-and-emerging-trends-in-colorectal-cancer-screening-and-diagnostics","Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics","","Colorectal cancer (CRC) is a prevalent, potentially fatal disease, driving demand for reliable diagnostic approaches to support early detection and effective management. Conventional diagnostics offer some capability but face limitations in sensitivity, specificity, and validation. Research increasingly explores molecularly informed, non-invasive strategies, including microfluidic diagnostics that enable integrated workflows, faster processing, and improved detection performance. Advances also highlight artificial intelligence combined with microfluidic systems to enable accurate, efficient, personalized diagnostic and monitoring strategies for better patient outcomes.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/current-status-and-emerging-trends-in-colorectal-cancer-screening-and-diagnostics/382986/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/current-status-and-emerging-trends-in-colorectal-cancer-screening-and-diagnostics/382986.png","ImageObject",300,407,{"name":92,"@type":93},"Aran","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"Why is early diagnosis important for colorectal cancer (CRC)?","Question",{"text":112,"@type":113},"Early recognition of CRC signs and symptoms during asymptomatic or pre-cancerous stages can strongly influence treatment options and overall prognosis, including survival and quality of life.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What screening and diagnostic methods are commonly used for CRC?",{"text":117,"@type":113},"Standard modalities include stool-based screening such as FOBT and FIT, stool DNA tests, and direct visualization through colonoscopy or CT colonography. Blood-based biomarkers like CEA and circulating tumor DNA (ctDNA) are also discussed.",{"name":119,"@type":110,"acceptedAnswer":120},"How do microfluidic diagnostics improve CRC detection compared with conventional approaches?",{"text":121,"@type":113},"Microfluidic devices integrate multiple sample preparation steps into a single platform, enabling faster processing and improved sensitivity, supporting non-invasive real-time monitoring of disease progression and treatment response.",{"name":123,"@type":110,"acceptedAnswer":124},"What role does artificial intelligence play in CRC diagnostics?",{"text":125,"@type":113},"AI-driven approaches combined with microfluidic systems are presented as promising for enhancing diagnostic capabilities, aiming to deliver accurate, efficient, and personalized strategies that improve patient outcomes.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},382986,1791449592,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149},137455076865,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","biosensors  \nReview  \nCurrent Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics  \nShreya Singh Beniwal 1, Paula Lamo 2, Ajeet Kaushik 3, Dionisio Lorenzo Lorenzo-Villegas 4, Yuguang Liu 5, * and ArunSundar MohanaSundaram 6, *  \nCitation: Beniwal, S.S.; Lamo, P.; Kaushik, A.; Lorenzo-Villegas, D.L.; Liu, Y.; MohanaSundaram, A. Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics. Biosensors 2023, 13, 926 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)bios13100926  \nReceived: 29 August 2023  \nRevised: 27 September 2023  \nAccepted: 7 October 2023  \nPublished: 13 October 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Lady Hardinge Medical College, Connaught Place, New Delhi 110001, India  \n2 Escuela Superior de Ingenier½a y Tecnolog½a, Universidad Internacional de La Rioja,  \n26006 Logroño, Spain  \n3 NanoBioTech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, Lakeland, FL 33805, USA  \n4 Faculty of Health Sciences, University Fernando Pessoa-Canarias, 35450 Santa Maria de Guia, Spain  \n5 Departments of Physiology and Biomedical Engineering, Immunology and Surgery, Microbiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA  \n6 School of Pharmacy, Sathyabama Institute of Science and Technology, Chennai 600 119, India  \n* Correspondence: [liu.yuguang@mayo.edu](liu.yuguang@mayo.edu) (Y.L.); [arunsundar.pharmacy@sathyabama.ac.in](arunsundar.pharmacy@sathyabama.ac.in) (A.M.)  \nAbstract: Colorectal cancer (CRC) is a prevalent and potentially fatal disease categorized based on its high incidences and mortality rates, which raised the need for effective diagnostic strategies for the early detection and management of CRC. While there are several conventional cancer diagnostics available, they have certain limitations that hinder their effectiveness. Significant research efforts are currently being dedicated to elucidating novel methodologies that aim at comprehending the intricate molecular mechanism that underlies CRC. Recently, microfluidic diagnostics have emerged as a pivotal solution, offering non-invasive approaches to real-time monitoring of disease progression and treatment response. Microfluidic devices enable the integration of multiple sample preparation steps into a single platform, which speeds up processing and improves sensitivity. Such advancements in diagnostic technologies hold immense promise for revolutionizing the field of CRC diagnosis and enabling efficient detection and monitoring strategies. This article elucidates several of the latest developments in microfluidic technology for CRC diagnostics. In addition to the advancements in microfluidic technology for CRC diagnostics, the integration of artificial intelligence (AI) holds great promise for further enhancing diagnostic capabilities. Advancementsin microfluidic systems and AI-driven approaches can revolutionize colorectal cancer diagnostics, offering accurate, efficient, and personalized strategies to improve patient outcomes and transform cancer management.  \nKeywords: colorectal cancer; standard practices; non-invasive; diagnostic; microfluidics  \n1. Introduction  \nColorectal cancer (CRC) represents a significant global health burden, ranking as the second most prevalent cause of cancer-related mortality and the third most widespread malignant neoplasm. CRC primarily affects the colon and rectum, which are integral components of the gastrointestinal tract responsible for waste processing and elimination [1] . Recent epidemiological data from 2020 to 2021 reported a mortality rate of 9.4%, accompanie","cbCaicTawQgVLhJ2","https://ap.wps.com/l/cbCaicTawQgVLhJ2","pdf",4417837,27,"English","# Introduction\n## Epidemiology and disease burden\n## Need for early-stage detection and screening modalities\n## Conventional diagnostics and limitations","[{\"question\":\"Why is early diagnosis important for colorectal cancer (CRC)?\",\"answer\":\"Early recognition of CRC signs and symptoms during asymptomatic or pre-cancerous stages can strongly influence treatment options and overall prognosis, including survival and quality of life.\"},{\"question\":\"What screening and diagnostic methods are commonly used for CRC?\",\"answer\":\"Standard modalities include stool-based screening such as FOBT and FIT, stool DNA tests, and direct visualization through colonoscopy or CT colonography. Blood-based biomarkers like CEA and circulating tumor DNA (ctDNA) are also discussed.\"},{\"question\":\"How do microfluidic diagnostics improve CRC detection compared with conventional approaches?\",\"answer\":\"Microfluidic devices integrate multiple sample preparation steps into a single platform, enabling faster processing and improved sensitivity, supporting non-invasive real-time monitoring of disease progression and treatment response.\"},{\"question\":\"What role does artificial intelligence play in CRC diagnostics?\",\"answer\":\"AI-driven approaches combined with microfluidic systems are presented as promising for enhancing diagnostic capabilities, aiming to deliver accurate, efficient, and personalized strategies that improve patient outcomes.\"}]","Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics | PDF",1790253436,68]