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Rationally designed nanocarriers support targeted drug delivery to tumor tissues via passive or active mechanisms, improving efficacy while reducing damage to healthy sites. The review also summarizes nanotechnology roles in radiation sensitization, photothermal therapy, and discusses emerging advances, prospects, and challenges.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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www.nature.com/sigtrans](and Targeted Therapy www.nature.com/sigtrans)  \nREVIEW ARTICLE  \nOPEN  \nCurrent advance of nanotechnology in diagnosis and treatment for malignant tumors  \nBilan Wang1,2, Shiqi Hu2,3, Yan Teng4, Junli Chen5, Haoyuan Wang6, Yezhen Xu6, Kaiyu Wang6, Jianguo Xu6, Yongzhong Cheng6 ✉ and Xiang Gao 6 ✉  \n\n|  | Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engineered nanoparticles can be employed as contrast agents in cancer diagnostics to enable high sensitivity and high-resolution tumor detection by imaging examinations. Novel approaches for tumor labeling and detection are also made possible by the use of nanoprobes and nanobiosensors. The achievement of targeted medication delivery in cancer therapy can be accomplished through the rational design and manufacture of nanodrug carriers. Nanoparticles have the capability to effectively transport medications or gene fragments to tumor tissues via passive or active targeting processes, thus enhancing treatment outcomes while minimizing harm to healthy tissues. Simultaneously, nanoparticles can be employed in the context of radiation sensitization and photothermal therapy to enhance the therapeutic efficacy of malignant tumors. This review presents a literature overview and summary of how nanotechnology is used in the diagnosis and treatment of malignant tumors. According to oncological diseases originating from different systems of the body and combining the pathophysiological features of cancers at different sites, we review the mostrecent developments in nanotechnology applications. Finally, we briefly discuss the prospects and challenges of nanotechnology in |  |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| cancer. |  |  |\n|  | Signal Transduction and Targeted Therapy (2024)9:200 ; [https://doi.org/10.1038/s41392-024-01889-y](https://doi.org/10.1038/s41392-024-01889-y) |  |\n|  |  |  |\n\nINTRODUCTION  \nCancer is one of the leading causes of death globally, with an approximate incidence of 19.3 million newly diagnosed cases and about 10 .0 million fatalities annually.1,2 Due to its ever-growing incidence and mortality rate, it has become one of the highest challenges for a longer life expectancy worldwide. Although in developed countries like the United States, general cancer incidence and mortality rates have been gradually decreasing in the past decade owing to new research on tumor mechanisms, improved diagnostic tools, and new therapeutic strategies, the burden of cancer remains a major challenge in developing as well as developed economies.2–7 It is in urgent demand for more ground-breaking innovations and ever-improving tactics, together with a better understanding and utilization of existing cancer management strategies.  \nCommon treatments, including surgery, radiotherapy, and chemotherapy, have been applied to most patients with malignant tumors, either in combination or separately. Although surgery is regarded as an irreplaceable treatment for most solid localized tumors, systematic treatment is required as a  \nsupplement upon the occurrence of metastasis.8–14 Radiation therapy is used in more than half of patients with cancer and isone of the most effective treatment modalities,15–21 but it remains a huge challenge to alleviate short-and long-term toxicity.15,22–26 Traditional chemotherapy is also facing great challenges due to its inherent properties, such as instability, insolubility, drug resistance, and prominent tissue damage.27–34 Also, the traditional systematic administration of drugs has put all somatic cells at risk of toxicity. However, there are ways of reducing","cbCaibDODdtAPyuD","https://ap.wps.com/l/cbCaibDODdtAPyuD","pdf",4589639,65,"English","# Overview and scope\n## Nanoparticles for diagnosis and tumor detection\n## Nanocarriers for targeted therapy\n## Enhancing therapy: radiation sensitization and photothermal therapy\n## Prospects and challenges","[{\"question\":\"How do engineered nanoparticles improve cancer diagnosis?\",\"answer\":\"They act as contrast agents enabling high-sensitivity, high-resolution tumor detection, and they support tumor labeling and detection through nanoprobes and nanobiosensors.\"},{\"question\":\"What is the role of nanocarriers in cancer treatment?\",\"answer\":\"Nanocarriers deliver medications or gene fragments to tumor tissues through passive or active targeting, enhancing treatment outcomes while minimizing harm to healthy tissues.\"},{\"question\":\"How does nanotechnology enhance therapeutic effectiveness beyond drug delivery?\",\"answer\":\"It can improve outcomes in radiation sensitization and photothermal therapy, increasing the therapeutic efficacy of malignant tumors.\"}]","Current advance of nanotechnology in diagnosis and treatment for malignant tumors | PDF",1790003452,164]