[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332805-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332805-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","curcumin-derivatives-in-medicinal-chemistry-potential-applications-in-cancer-treatment","Curcumin Derivatives in Medicinal Chemistry: Potential Applications in Cancer Treatment","","Curcumin, a naturally occurring compound from Curcuma plants, shows anti-inflammatory, antioxidant, and anticancer activities and has been reported to inhibit tumor growth across multiple cancer types. Its clinical use remains constrained by low chemical stability, poor water solubility, and limited bioavailability. Structural modifications aim to enhance pharmacological performance, including improved anticancer selectivity and bioavailability. This review summarizes curcumin chemical derivatives that could support more effective anticancer therapies by improving stability and therapeutic potential.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/curcumin-derivatives-in-medicinal-chemistry-potential-applications-in-cancer-treatment/332805/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/curcumin-derivatives-in-medicinal-chemistry-potential-applications-in-cancer-treatment/332805.png","ImageObject",300,407,{"name":42,"@type":43},"Seraphina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-12","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are curcumin derivatives being studied for cancer treatment?","Question",{"text":63,"@type":64},"Curcumin shows anticancer activity but has clinical limitations due to low stability, poor solubility, and low bioavailability. 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Mlynarczyk 3, Pawel Bakun 3, Izabela Muszalska-Kolos 1, Katarzyna Dettlaff 1, Agnieszka Sobczak 1, Tomasz Goslinski 3, * and Anna Jelinska 1  \nCitation: Kuzminska, J.; Szyk, P.; Mlynarczyk, D.T.; Bakun, P.;  \nMuszalska-Kolos, I.; Dettlaff, K.; Sobczak, A.; Goslinski, T.; Jelinska, A. Curcumin Derivatives in Medicinal Chemistry: Potential Applications in Cancer Treatment. Molecules 2024, 29, 5321. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)molecules29225321  \nAcademic Editor: Ines Bruno  \nReceived: 10 September 2024  \nRevised: 20 October 2024  \nAccepted: 4 November 2024  \nPublished: 12 November 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Rokietnicka 3,  \n60-806 Poznan, Poland; [imuszals@ump.edu.pl](imuszals@ump.edu.pl) (I.M.-K.); [dettlaff@ump.edu.pl](dettlaff@ump.edu.pl) (K.D.);  \n[asobczak@ump.edu.pl](asobczak@ump.edu.pl) (A.S.); [ajelinsk@ump.edu.pl](ajelinsk@ump.edu.pl) (A.J.)  \n2 Doctoral School, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland; [piotr.szyk@student.ump.edu.pl](piotr.szyk@student.ump.edu.pl)  \n3 Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland; [mlynarczykd@ump.edu.pl](mlynarczykd@ump.edu.pl) (D.T.M.); [pbakun@ump.edu.pl](pbakun@ump.edu.pl) (P.B.)  \n* [Correspondence: jkuzminska@ump.edu.pl](Correspondence: jkuzminska@ump.edu.pl) (J.K.); [tomasz.goslinski@ump.edu.pl](tomasz.goslinski@ump.edu.pl) (T.G.)  \nAbstract: Curcumin, a naturally occurring compound found in the rhizome of Curcuma plants, particularly in turmeric (Curcuma longa L.), exhibits a broad range of biological activities, including anti-inflammatory, antioxidant, and anticancer properties. Curcumin has demonstrated effectiveness in inhibiting tumor growth, arousing interest for its potential in treating various cancers, such as breast, lung, prostate, and brain cancers. However, the clinical application of curcumin is limited due to its low chemical stability, poor water solubility, and low bioavailability. In response to these challenges, structural modifications of curcumin have been explored to improve its pharmacological properties, including enhanced anticancer selectivity index and bioavailability. This review highlights promising chemical modifications of curcumin that could lead to the development of more effective anticancer therapies. By functionalizing the parent curcumin molecule, researchers aim to create more stable and bioavailable compounds with enhanced therapeutic potential, making curcumin derivatives promising candidates for medical applications.  \nKeywords: curcumin; cancer; curcumin derivatives  \n1. Introduction  \nCurcumin or (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, is a compound present in the rhizome of the Curcuma genus plants, most notably in turmeric (Curcuma longa L.) . Historically, curcumin’s vivid color led to its use as a dye, while its flavor made it popular as a kitchen spice. It is also worth remembering that turmeric, containing curcumin, has been used in traditional medicine for many centuries [1] . Curcumin is classified as a diarylheptanoid. Diarylheptanoids are a group of compounds characterized by two aromatic rings connected by a seven-carbon chain. Depending on the type of seven-carbon unit connecting these rings, diarylheptanoids are divided into four subgroups. These include: (","cbCaikpVOWA1cOV0","https://ap.wps.com/l/cbCaikpVOWA1cOV0","pdf",4581045,35,"English","# Introduction\n## Biological activities and medicinal relevance\n## Chemical challenges and need for derivatives","[{\"question\":\"Why are curcumin derivatives being studied for cancer treatment?\",\"answer\":\"Curcumin shows anticancer activity but has clinical limitations due to low stability, poor solubility, and low bioavailability. Modifying its structure can improve pharmacological properties and therapeutic potential.\"},{\"question\":\"What biological activities does curcumin exhibit?\",\"answer\":\"Curcumin exhibits anti-inflammatory, antioxidant, and anticancer properties. Its effects are associated with promoting or inhibiting specific enzymes and cellular pathways.\"},{\"question\":\"What types of cancers does curcumin show potential against?\",\"answer\":\"The document reports effectiveness across several cancer types, including breast, lung, prostate, and brain cancers, along with additional examples such as kidney and uterine cancers.\"}]","Curcumin Derivatives in Medicinal Chemistry: Potential Applications in Cancer Treatment | PDF",1789999567,88]