[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378671-105":59,"doc-detail-378671-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","cuproptosis-mechanisms-and-links-with-cancers-review","Cuproptosis: mechanisms and links with cancers - review","","Cuproptosis is a copper-dependent, distinct type of regulated cell death, distinct from previously known cell death pathways. Rising interest in programmed cell death has focused on whether copper-triggered death represents an independent mechanism, clarified as cuproptosis emerged. This review organizes copper’s systemic and cellular metabolic processes and the copper-related tumor signaling networks, then summarizes discovery and mechanistic insights and their cancer associations. It further discusses therapeutic prospects combining copper ionophores that induce cuproptosis with small-molecule drugs for targeted cancer treatment.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cuproptosis-mechanisms-and-links-with-cancers-review/378671/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cuproptosis-mechanisms-and-links-with-cancers-review/378671.png","ImageObject",300,407,{"name":92,"@type":93},"moss~","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is cuproptosis?","Question",{"text":113,"@type":114},"Cuproptosis is a copper-dependent type of regulated cell death that is distinct from existing forms of cell death. It is discussed as an independent mechanism once its underlying process was revealed.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does copper relate to cancer biology in this review?",{"text":118,"@type":114},"Copper is described as a trace element strongly associated with signaling pathways and tumor-related biological behaviors. The review links cuproptosis to cancer progression through copper-related metabolic processes and tumor signaling pathways.",{"name":120,"@type":111,"acceptedAnswer":121},"What therapeutic direction does the review propose?",{"text":122,"@type":114},"The review highlights targeted therapeutic strategies using copper ionophores that induce cuproptosis, combined with small-molecule drugs, aiming to treat specific cancers. It also emphasizes the relevance to cancer subtypes exhibiting high mitochondrial metabolic states.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378671,1790820142,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090895452,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Xie etal. Molecular Cancer (2023) 22:46 [https://doi.org/10.1186/s12943-023-01732-y](https://doi.org/10.1186/s12943-023-01732-y)  \nMolecular Cancer  \n REVIEW Open Access  \nCuproptosis: mechanisms and links with cancers  \nJiaming Xie1,2†, Yannan Yang1,2†, Yibo Gao3,4* and Jie He1,2,4*  \nAbstract  \nCuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death, and whether copper induced cell death was an independent form of cell death has long been argued until mechanism of cuproptosis has been revealed. After that, increasing number of researchers attempted to identify the relationship between cuproptosis and the process of cancer. Thus, in this review, we systematically detailed the systemic and cellular metabolic processes of copper and the copper-related tumor signaling pathways. Moreover, we not only focus on the discovery process of cuproptosis and its mechanism, but also outline the association between cuproptosis and cancers. Finally, we further highlight the possible therapeutic direction of employing copper ion ionophores with cuproptosisinducing functions in combination with small molecule drugs for targeted therapy to treat specific cancers.  \nKeywords Cuproptosis, Copper, Cancer, Targeted therapy, Immunotherapy, Drug resistance, Metabolism  \n†Jiaming Xie andYannan Yang contributed equally to this work.  \n*Correspondence: Yibo Gao [gaoyibo@cicams.ac.cn](gaoyibo@cicams.ac.cn)[ ](gaoyibo@cicams.ac.cn)Jie He[hejie@cicams.ac.cn](hejie@cicams.ac.cn)  \n1 Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China  \n2 State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China  \n3 Central Laboratory & Shenzhen Key Laboratory of Epigeneticsand Precision Medicine for Cancers, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China  \n4 Laboratory of Translational Medicine, National Cancer Center/National, Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 101399, China  \nBackground  \nIn the recent years, cuproptosis, a novel form of regulated cell death which is copper dependent has been identified [1, 2], may be implicated in the process of various cancers. Copper is a trace element in the human body and has been strongly associated with various signaling pathways and tumor-related biological behaviors [3]. Moreover, excess copper can lead to cell death, and for along time the mechanisms and specific forms of copperinduced cell death have remained unclear. Until early this year, it has been suggested by a recent study that cuproptosis is an independent form of cell death, which was considered to be highly correlated with mitochondrial respiration and lipoic acid(LA) pathway [4]. We briefly summarize some of the findings on copper-induced cell  \ndeath that have driven progress in the field (Fig. 1).  \nA considerable number of researchers focusing on the pivotal relationship between cuproptosis and cancers. On the one hand, cancer has multiple types, with sufficient multi-omics data. On the other hand, cuproptosis  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons ","cbCaiifR9N78vYjw","https://ap.wps.com/l/cbCaiifR9N78vYjw","pdf",2578525,"English","# Abstract\n# Background\n## Copper and regulated cell death\n## Cuproptosis links to cancer metabolism\n## Mitochondrial respiration and lipoic acid pathway","[{\"question\":\"What is cuproptosis?\",\"answer\":\"Cuproptosis is a copper-dependent type of regulated cell death that is distinct from existing forms of cell death. It is discussed as an independent mechanism once its underlying process was revealed.\"},{\"question\":\"How does copper relate to cancer biology in this review?\",\"answer\":\"Copper is described as a trace element strongly associated with signaling pathways and tumor-related biological behaviors. The review links cuproptosis to cancer progression through copper-related metabolic processes and tumor signaling pathways.\"},{\"question\":\"What therapeutic direction does the review propose?\",\"answer\":\"The review highlights targeted therapeutic strategies using copper ionophores that induce cuproptosis, combined with small-molecule drugs, aiming to treat specific cancers. It also emphasizes the relevance to cancer subtypes exhibiting high mitochondrial metabolic states.\"}]","Cuproptosis: mechanisms and links with cancers - review | PDF",1790231869,76]