[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331618-105":59,"doc-detail-331618-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","crosstalk-between-metabolic-and-epigenetic-modifications-during-cell-carcinogenesis","Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis","","Cancer arises from mutations driven by internal and external factors, leading to metabolic reprogramming and epigenetic remodeling that together sustain abnormal proliferation. The review explains how altered metabolic enzyme expression and metabolite accumulation can supply substrates or cofactors for chromatin-modifying enzymes, thereby promoting carcinogenesis. It also covers reciprocal feedback where epigenetic changes shape metabolic adaptation and immune evasion, discusses metabolite-driven epigenetic marks (lactylation, acetylation, succinylation, crotonylation), and summarizes implications for tumor immunity and therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/crosstalk-between-metabolic-and-epigenetic-modifications-during-cell-carcinogenesis/331618/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/crosstalk-between-metabolic-and-epigenetic-modifications-during-cell-carcinogenesis/331618.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does metabolic reprogramming contribute to epigenetic changes in cancer cells?","Question",{"text":112,"@type":113},"Metabolic reprogramming alters metabolic enzyme expression and causes metabolite accumulation. Many metabolites then act as substrates or cofactors for chromatin-modifying enzymes, enabling epigenetic modifications that promote carcinogenesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What types of epigenetic modifications are linked to metabolites in the review?",{"text":117,"@type":113},"The review discusses metabolite-associated epigenetic remodeling including lactylation, acetylation, succinylation, and crotonylation, and explains how these marks can regulate gene expression and tumor progression.",{"name":119,"@type":110,"acceptedAnswer":120},"What role do epigenetic modifications play in tumor immunity?",{"text":121,"@type":113},"Epigenetic modifications influence metabolic reprogramming and immune evasion. By shaping how cancer cells respond to immune surveillance, these changes affect cancer progression and therapeutic targeting strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331618,1790195686,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","iScience  \nll  \nOPEN ACCESS  \nReview  \nCrosstalk between metabolic and epigenetic modiﬁcations during cell carcinogenesis  \nYue Gao,1,3 Siyu zhang,2,3 Xianhong Zhang,1,3 Yitian Du,1 Ting Ni,1,* and Shuailin Hao1,*  \n1State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China  \n2Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China  \n3These authors contributed equally  \n*Correspondence: [tingni@fudan.edu.cn](tingni@fudan.edu.cn) (T.N.), [shuailh@imu.edu.cn](shuailh@imu.edu.cn) (S.H.) [https://doi.org/10.1016/j.isci.2024.111359](https://doi.org/10.1016/j.isci.2024.111359)  \nSUMMARY  \nGenetic mutations arising from various internal and external factors drive cells to become cancerous. Cancerous cells undergo numerous changes, including metabolic reprogramming and epigenetic modiﬁcations, to support their abnormal proliferation. This metabolic reprogramming leads to the altered expression of many metabolic enzymes and the accumulation of metabolites. Recent studies have shown that these enzymes and metabolites can serve as substrates or cofactors for chromatin-modifying enzymes, thereby participating in epigenetic modiﬁcations and promoting carcinogenesis. Additionally, epigenetic modiﬁcations play a role in the metabolic reprogramming and immune evasion of cancer cells, inﬂuencing cancer progression. This review focuses on the origins of cancer, particularly the metabolic reprogramming of cancer cells and changes in epigenetic modiﬁcations. We discuss how metabolites in cancer cells contribute to epigenetic remodeling, including lactylation, acetylation, succinylation, and crotonylation. Finally, we review the impact of epigenetic modiﬁcations on tumor immunity and the latest advancements in cancer therapies targeting these modiﬁcations.  \nINTRODUCTION  \nCancer is a disease characterized by genomic instability in somatic cells. Genomic variation, including gene mutations, chromosomal rearrangements, and gene copy number variations, can directly or indirectly affect cell growth, differentiation, and death, promoting cancer development.1 Genes regulate the synthesis of proteins, which play a vital role in maintaining normal cellular function. Mutations in cancer genes can result in the production of dysfunctional or deformed proteins, leading to abnormal signaling within cells and subsequent metabolic reprogramming in cancer cells.2 In eukaryotic cells, including cancer cells, genomic DNA is packaged into chromatin by forming nucleosomes. Each nucleosome core particle consists of a histone octamer and approximately 146 base pairs of DNA, with the histone octamer comprising two copies each of the core histones H2A, H2B, H3, and H4 .3 The histone amino-terminal tails and globular histone cores protruding from the nucleosome undergo a variety of covalent modiﬁcations, including acetylation, ubiquitination, phosphorylation, methylation, succinylation, glycosylation, propionylation, borylation, and crotonylation.4 Increasing evidence indicates that abnormal regulation of DNA modiﬁcations and histone post-translational modiﬁcations is closely related to cancer. These modiﬁcations can alter chromatin structure and protein-protein interactions, thereby regulating gene transcription and mediating cancer development by  \naffecting critical physiological processes such as DNA damage repair, cell cycle progression, and epigenetic changes.5  \nGlucose, protein, and fat metabolism in cells is regulated by metabolic enzymes at the gene expression or protein level, responding to normal extracellular and intracellular signals. Cancer cells, however, meet their energy needs for abnormal proliferation and adapt to changing environments through metabolic reprogramming. Increased metabolic pathwa","cbCaif5Cxh5BJih9","https://ap.wps.com/l/cbCaif5Cxh5BJih9","pdf",4416900,27,"English","# Summary\n# Introduction\n# The Cause of Cancer","[{\"question\":\"How does metabolic reprogramming contribute to epigenetic changes in cancer cells?\",\"answer\":\"Metabolic reprogramming alters metabolic enzyme expression and causes metabolite accumulation. Many metabolites then act as substrates or cofactors for chromatin-modifying enzymes, enabling epigenetic modifications that promote carcinogenesis.\"},{\"question\":\"What types of epigenetic modifications are linked to metabolites in the review?\",\"answer\":\"The review discusses metabolite-associated epigenetic remodeling including lactylation, acetylation, succinylation, and crotonylation, and explains how these marks can regulate gene expression and tumor progression.\"},{\"question\":\"What role do epigenetic modifications play in tumor immunity?\",\"answer\":\"Epigenetic modifications influence metabolic reprogramming and immune evasion. By shaping how cancer cells respond to immune surveillance, these changes affect cancer progression and therapeutic targeting strategies.\"}]","Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis | PDF",1789994335,68]