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Despite advances in surgery, radiation, chemotherapy, targeted therapy, and immunotherapy, many patients still experience severe treatment resistance. Deeper understanding of cancer growth and resistance mechanisms is required. Ferroptosis is an iron-dependent cell death marked by excessive lipid peroxidation and is gaining attention in cancer. Extracellular vesicles (EVs) are key mediators of cell-to-cell communication and can be used to target ferroptosis for cancer therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/crosstalk-between-ferroptosis-and-extracellular-vesicles-in-cancer-from-interaction-to-clinical-application-review/350886/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/crosstalk-between-ferroptosis-and-extracellular-vesicles-in-cancer-from-interaction-to-clinical-application-review/350886.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the review highlight in cancer treatment?","Question",{"text":112,"@type":113},"Many cancer patients continue to suffer due to severe treatment resistance, despite major therapeutic advances. 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The review notes evidence linking EVs and ferroptosis and suggests that ferroptosis-targeting EVs may be used to treat cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},350886,1790143549,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Liu et al. Experimental Hematology & Oncology (2026) 15:7 [https://doi.org/10.1186/s40164-025-00736-2](https://doi.org/10.1186/s40164-025-00736-2)  \nExperimental Hematology & Oncology  \nREVIEW Open Access  \nCrosstalk between ferroptosisand extracellular vesicles in cancer:  \nfrom interaction to clinical application  \nJingyi Liu1†, Kewei Wang2†, Zhixiong Hao3†, Qing Fan3, Shuang Ma4* and Lei Xu5*  \nAbstract  \nCancer continues to pose a significant issue to public health. Despite the considerable advancements in popular therapies such as surgery, radiation, chemotherapy, targeted therapy, and immunotherapy, a substantial number of patients continue to suffer from cancer due to severe treatment resistance. As a result, it is imperative to have a deeper understanding of the mechanisms behind cancer growth and therapy resistance. Ferroptosis, an irondependent form of cell death characterized by excessive lipid peroxidation, has recently been described, attracting heightened interest in its implications in cancer. Ferroptosis offers a new conceptual framework for understanding cancer progression. Some treatments function via regulating ferroptosis, and the tough insensitive to various therapies also involves ferroptosis resistance. Hence, targeting ferroptosis may benefit the cancer treatments. Extracellular vesicles (EVs) are essential mediators in cell-to-cell communications and are significantly impacted by environmental or cellular stress. The relationship between EVs and ferroptosis has recently been steadily demonstrated, and it has also been possible to use EVs to target ferroptosis to treat cancer. We present a novel perspective on cancer by reexamining the existing knowledge of ferroptosis and EVs in this disease. This includes a comprehensive overview of the relationships between ferroptosis and EVs and their therapeutic applications, focusing on contemporary ferroptosis-targeting EVs in the context of cancer.  \nKeywords Ferroptosis, Extracellular vesicles, Cancer treatment, Cell communication  \n†Jingyi Liu, Kewei Wang and Zhixiong Hao are contributed equally to this work.  \n*Correspondence: Shuang Ma [20072280@cmu.edu.cn](20072280@cmu.edu.cn)[ ](20072280@cmu.edu.cn)Lei Xu [xulei@cmu.edu.cn](xulei@cmu.edu.cn)  \n1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China  \n2Department of Gastrointestinal Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China  \n3Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China  \n4Nursing Department, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China  \n5Center for Health Management, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China  \nIntroduction  \nCancers remain the predominant cause of mortality in humans and a significant strain on the global healthcare system. Cancer treatment has evolved from traditional surgery, radiation, and chemotherapy to modern approaches, including targeted therapy, immunotherapy, neoadjuvant therapy, combination therapy, adoptive cell therapy, antibody-drug conjugates, and cancer vaccines. A portion of cancer patients derive advantages from various treatment regimens. Many individuals persist in resisting existing treatments and ultimately succumb to cancer. In consideration of this condition, we must reassess our comprehension of cancer from a fresh perspective. Approximately a decade ago, a distinctive kind of cell  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not","cbCaiqcReTj7SUsa","https://ap.wps.com/l/cbCaiqcReTj7SUsa","pdf",4629050,24,"English","# Introduction\n## Ferroptosis in cancer and related diseases\n## Extracellular vesicles (EVs) in cell communication\n## EV–ferroptosis interactions and therapeutic implications","[{\"question\":\"What problem does the review highlight in cancer treatment?\",\"answer\":\"Many cancer patients continue to suffer due to severe treatment resistance, despite major therapeutic advances. The review emphasizes the need to better understand mechanisms behind cancer growth and resistance.\"},{\"question\":\"How does the review describe ferroptosis?\",\"answer\":\"Ferroptosis is described as an iron-dependent form of cell death characterized by excessive lipid peroxidation. It provides a conceptual framework for understanding cancer progression and resistance.\"},{\"question\":\"Why are extracellular vesicles (EVs) important for targeting ferroptosis?\",\"answer\":\"EVs are essential mediators in cell-to-cell communications and can reflect cellular states. The review notes evidence linking EVs and ferroptosis and suggests that ferroptosis-targeting EVs may be used to treat cancer.\"}]","Crosstalk between ferroptosis and extracellular vesicles in cancer - from interaction to clinical application - Review | PDF",1790091653]