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The HCI is designed to reflect health effects from multi-year caloric restriction studies in older adults with overweight or obesity, evaluated over five years using a 937-participant subset. Components relate to baseline BMI and body fat, show rising prevalence, and the composite index predicts faster progression and higher mortality risk, with hazard ratio 1.22.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/creation-of-a-multimorbidity-health-conditions-index-for-caloric-restriction-studies-in-older-adults-abstract/426569/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/creation-of-a-multimorbidity-health-conditions-index-for-caloric-restriction-studies-in-older-adults-abstract/426569.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the Health Conditions Index (HCI) and what conditions does it cover?","Question",{"text":112,"@type":113},"The HCI is a composite multimorbidity index based on 29 obesity-related conditions. It is intended to quantify health outcomes associated with caloric restriction over time.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the HCI evaluated in the study?",{"text":117,"@type":113},"Researchers used a subset of participants from the Health, Aging and Body Composition Cohort Study for whom weight loss would be expected. Outcomes and HCI components were assessed over five years of follow-up.",{"name":119,"@type":110,"acceptedAnswer":120},"What baseline factors and outcomes were associated with the HCI?",{"text":121,"@type":113},"HCI components were consistently related to initial BMI and percent body fat. The composite HCI showed faster progression and a statistically significant increase in mortality rate over five years.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426569,1791161966,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","Innovation in Aging, 2025, Vol. 9, No. S2 303  \nAbstract citation ID: igaf122.1021  \nCREATION OF A MULTIMORBIDITY HEALTH  \nCONDITIONS INDEX FOR CALORIC RESTRICTION  \nSTUDIES IN OLDER ADULTS  \nMichael Miller1, Haiying Chen1, Mark Espeland1, Fang-Chi Hsu1, Denise Houston1, Anne Newman2,  \nW. Jack Rejeski3, and Stephen Kritchevsky1, 1. Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States, 2. University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 3. Wake Forest University, WinstonSalem, North Carolina, United States  \nUsing multiple sources, we provide the conceptual justification and statistical support for a multimorbidity outcome associated with 29 obesity-related conditions, which we term the Health Conditions Index (HCI) . The HCI was designed to capture the health effects of multi-year studies of caloric restriction in older adults with overweight or obesity. We used a subset of participants from the Health, Aging and Body Composition Cohort Study for whom weight loss would be indicated to evaluate multiple aspects of the index and its components over five years of follow-up. The 937 participants in the subset had an average age of 73 years and BMI of 30.7 kg/m2, 53% were female and 43% were Black. The components of the HCI were consistently related to initial BMI and percent body fat on cohort entry, generally showed an increasing prevalence over the 5-yr follow-up, and, as a composite index, the HCI exhibited an association between faster progression and higher initial levels of age, BMI, and percent body fat. Further, the initial HCI was associated with a statistically significant increase in the rate of mortality over 5-years of follow-up (hazard ratio [95% CI]: 1.22 [1.04, 1.44]) . By using outcomes like the HCI, clinical trials of caloric restriction in older adults may gain a better understanding of how intentional weight loss relates to future risk of multiple health conditions associated with aging.","cbCainfyZyArQX67","https://ap.wps.com/l/cbCainfyZyArQX67","pdf",317960,"English","# Abstract\n## Health Conditions Index (HCI) design\n## Study cohort and follow-up\n## Associations with BMI, body fat, and mortality","[{\"question\":\"What is the Health Conditions Index (HCI) and what conditions does it cover?\",\"answer\":\"The HCI is a composite multimorbidity index based on 29 obesity-related conditions. It is intended to quantify health outcomes associated with caloric restriction over time.\"},{\"question\":\"How was the HCI evaluated in the study?\",\"answer\":\"Researchers used a subset of participants from the Health, Aging and Body Composition Cohort Study for whom weight loss would be expected. Outcomes and HCI components were assessed over five years of follow-up.\"},{\"question\":\"What baseline factors and outcomes were associated with the HCI?\",\"answer\":\"HCI components were consistently related to initial BMI and percent body fat. The composite HCI showed faster progression and a statistically significant increase in mortality rate over five years.\"}]","CREATION OF A MULTIMORBIDITY HEALTH CONDITIONS INDEX FOR CALORIC RESTRICTION STUDIES IN OLDER ADULTS - Abstract | PDF",1790640964]