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It compares anesthetic and sedative regimens including isoflurane, dexmedotomidine, ketamine, and xylazine, focusing on safety, efficacy (analgesia, sedation, immobilization), ease of administration, control status, and cost. It proposes a summer randomized assignment plan and evaluation workflow, with feedback guiding experimental design and sampling goals.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cpc-pika-handling-and-anesthesia-protocols-justification-considerations-plans-feedback/388423/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cpc-pika-handling-and-anesthesia-protocols-justification-considerations-plans-feedback/388423.png","ImageObject",300,407,{"name":42,"@type":43},"Kurz","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-25",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why does the protocol emphasize restricted safe drug options for pikas?","Question",{"text":63,"@type":64},"The document notes limited known safe drugs for lagomorphs compared with carnivores and rodents, and highlights pika susceptibility to heat stress and idiosyncratic drug reactions.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What key safety and efficacy factors are evaluated for anesthesia and sedation?",{"text":68,"@type":64},"It covers safety, efficacy for analgesia, sedation, immobilization, stress and pain minimization, ease of delivery, non-controlled substance status, and expense.",{"name":70,"@type":61,"acceptedAnswer":71},"How will pikas be assigned to different anesthesia regimens in the plan?",{"text":72,"@type":64},"Pikas available over the summer will be randomly assigned in collaborative studies to three anesthetic regimens: isoflurane, dexmedotomidine, and dexmedotomidine with low-dose ketamine.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},388423,1790369847,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","CPC Pika handling and anesthesia protocols July 1, 2010  \nKatryna Fleer; Toni Lyn Morelli; Deana Clifford; Janet Foley;  \nPeter Pascoe  \nJustification  \n• Restricted range of known safe drugs for lagomorphs compared with carnivores and rodents.  \n• Pikas susceptible to heat stress, idiosyncratic drug reactions?  \n• Federal and state listing status  \n• Urgent need for data requiring hands-on work with pikas, e.g. some genetics studies, disease, et al. May require collar placement, blood sampling, skin snips, etc.  \nConsiderations  \n• Safety  \n• Efficacy: analgesia (relief from pain), sedation, immobilization, anesthesia for handling and minimizing stress, pain, and suffering  \n• “Easy” to deliver  \n• Non-controlled substances (DEA)  \n• Expense  \nIsoflurane  \n• Rapid acting inhalant “ether”-class anesthetic with some analgesia, already used in pikas  \n• Generally requires administration via calibrated vaporizer (but in a jar with a cotton wick in the field)  \n• Typically used with premed sedative  \n• No swallow reflexes, profound respiratory depressant, EASILY overdosed, rare malignant hyperthermia  \n• Very rapid induction & recovery, inexpensive/not  controlled   \nVeterinary Anaesthesia and Analgesia Vol.  \n33, 4 Pages: 207-213  \nDexmedotomidine  \n• Alpha-2 agonist sedative (not anesthetic) unless additional drugs are used, analgesic  \n• Can be reversed with atipamezole  \n• No respiratory depression, peripheral vasoconstriction reduces risk of hyperthermia  \n• Given as injection, not-controlled, relatively expensive  \nKetamine  \n• Dissociative anesthetic, binds to opioid receptors (hallucinogenic in people)  \n• Optimally used with sedative (xylazine or valium), quite safe, delivered by injection  \n• Relatively prolonged (rocky) recovery, controlled substance (drug of abuse in humans), inexpensive  \nXylazine  \n• alpha 2 agonist sedative or anesthetic, analgesic  \n• Can cause vomiting and heart rate depression (reduced blood pressure)  \n• Delivered by injection, inexpensive, not controlled  \nPlans  \n• Goal: Develop optimal anesthesia protocols for members of CPC & Western pika working group.  \n• Randomly assign pikas as available over the summer in collaborative studies to 3 different anesthetic regimens (isoflurane, dexmedotomidine, dexmedo with low-dose ketamine)  \n• Anesthetize, evaluate anesthesia, perform mildly noxious stimuli (exam, bleeding, ear tag, collar), recover & monitor  \nFeedback  \n• Value and need for hands-on pika work, costs vs. benefits  \n• Importance of: safety, cost, non-controlled, route, need for other equipment  \n• Input into experimental design?  \n• What are goals for handling – what sampling do we want to achieve?","cbCairJfc9b4I63Q","https://ap.wps.com/l/cbCairJfc9b4I63Q","pdf",79202,"English","# Justification\n## Considerations\n# Isoflurane\n# Dexmedotomidine\n# Ketamine\n# Xylazine\n# Plans\n# Feedback","[{\"question\":\"Why does the protocol emphasize restricted safe drug options for pikas?\",\"answer\":\"The document notes limited known safe drugs for lagomorphs compared with carnivores and rodents, and highlights pika susceptibility to heat stress and idiosyncratic drug reactions.\"},{\"question\":\"What key safety and efficacy factors are evaluated for anesthesia and sedation?\",\"answer\":\"It covers safety, efficacy for analgesia, sedation, immobilization, stress and pain minimization, ease of delivery, non-controlled substance status, and expense.\"},{\"question\":\"How will pikas be assigned to different anesthesia regimens in the plan?\",\"answer\":\"Pikas available over the summer will be randomly assigned in collaborative studies to three anesthetic regimens: isoflurane, dexmedotomidine, and dexmedotomidine with low-dose ketamine.\"}]","CPC Pika handling and anesthesia protocols - Justification - Considerations - Plans - Feedback | PDF",1790303327,25]