[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-376640-105":59,"doc-detail-376640-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","could-vaspin-be-a-potential-diagnostic-marker-in-endometrial-cancer","Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?","","Obesity and overweight increase risk for multiple cancers, including endometrial cancer (EC), and adipose tissue is described as an endocrine organ producing hormones such as vaspin. The study links insulin resistance, metabolic syndrome, and type 2 diabetes with higher vaspin levels, then measures serum vaspin in 127 patients divided into EC and non-cancer control groups. Grading and staging were considered, and ROC analysis with AUC estimated sensitivity and specificity. Results show significantly lower vaspin levels in EC versus benign endometrial lesions, suggesting vaspin may help distinguish benign lesions from EC.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/could-vaspin-be-a-potential-diagnostic-marker-in-endometrial-cancer/376640/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/could-vaspin-be-a-potential-diagnostic-marker-in-endometrial-cancer/376640.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study evaluate regarding vaspin?","Question",{"text":112,"@type":113},"The study evaluates whether serum vaspin can serve as a new diagnostic marker for endometrial cancer by comparing levels between EC and non-cancer controls and analyzing diagnostic performance using ROC/AUC.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many participants were included and how were they grouped?",{"text":117,"@type":113},"A total of 127 patients were included and divided into a study group with endometrial cancer and a control group with non-cancerous cases.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings about vaspin levels?",{"text":121,"@type":113},"Vaspin levels were significantly lower in patients with endometrial cancer than in patients with benign endometrial lesions, supporting its potential role in differentiating benign lesions from EC.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},376640,1790270260,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Article  \nCould Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?  \nDominika Pietrzyk 1, *, Piotr Tkacz 1, Mateusz Kozłowski 1, Sebastian Kwiatkowski 2,  \nMałgorzata Rychlicka 3, Ewa Pius-Sadowska 4, Bogusław Machali ´nski 4 and Aneta Cymbaluk-Płoska 1  \nCitation: Pietrzyk, D.; Tkacz, P.; Kozłowski, M.; Kwiatkowski, S.; Rychlicka, M.; Pius-Sadowska, E.; Machali ´nski, B.; Cymbaluk-Płoska, A. Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer? Int. J. Environ. Res. Public Health 2023, 20, 4999. [https://](https://)[ ](https://)[doi.org/10.3390/ijerph20064999](doi.org/10.3390/ijerph20064999)  \nAcademic Editor: Guglielmo Stabile  \nReceived: 10 January 2023  \nRevised: 5 March 2023  \nAccepted: 8 March 2023  \nPublished: 12 March 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powsta ´ncâw Wielkopolskich 72, 70-111 Szczecin, Poland  \n2 Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, Al. Powsta ´ncâw Wielkopolskich 72, 70-111 Szczecin, Poland  \n3 Department of Nursing, Pomeranian Medical University, 71-210 Szczecin, Poland  \n4 Department of General Pathology, Pomeranian Medical University in Szczecin, Al. Powsta ´ncâw Wielkopolskich 72, 70-111 Szczecin, Poland  \n* Correspondence: [dominikapietrzyk.lote@gmail.com](dominikapietrzyk.lote@gmail.com)  \nAbstract: Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with higher vaspin levels. A total of 127 patients divided into study (endometrial cancer) and control groups (non-cancerous) participated in this research. Serum vaspin levels were measured for all patients. The analysis was performed while taking into account grading and staging. In order to assess the usefulness of the tested protein as a new diagnostic marker, we used the plotting of a curve (ROC) and the calculation of the AUC curve to characterize the sensitivity and specificity of the parameters tested. We concluded that there were significantly lower vaspin levels in patients with endometrial cancer compared to patients with benign endometrial lesions. Vaspin may be a useful diagnostic marker in separating benign lesions from endometrial cancer.  \nKeywords: vaspin; cancer; endometrial cancer; diagnostic; diagnostic factor; obesity; insulin resistance  \n1. Introduction  \nEndometrial cancer (EC) is the sixth most common malignancy for women worldwide [1] . Its incidence is increasing, particularly in postmenopausal women. Only 4% of patients are under the age of 40 [2] . More than half of endometrial cancer cases are attributed to obesity, which has been identified as an independent risk factor for the disease [3] . Research confirms the link between obesity, hyperinsulinemia, type 2 diabetes and endometrial cancer [4–7] . The increase in cellular reactivity to insulin is connected with the activation of the MAPK/PI3K/AKT/mTOR signaling pathway, which is specific to cancer (EC) [8] . Often, this pathomechanism is further enhanced by the loss of the PTEN suppressor gene, which normally acts in opposition to the PI3K/AKT/mTOR pathway [9] . Bioavailable estrogens, especially when unopposed by progesterone, may increase the risk of EC through mitogenic effects in endometrial tissue [10] . Type I endometrial tumors usually express high levels of estrogen receptor (ER), and they are thought tobe hormonally dr","cbCaifaxbsvedcEa","https://ap.wps.com/l/cbCaifaxbsvedcEa","pdf",1450576,12,"English","# Introduction\n# Materials and Methods\n# Results\n# Discussion","[{\"question\":\"What does the study evaluate regarding vaspin?\",\"answer\":\"The study evaluates whether serum vaspin can serve as a new diagnostic marker for endometrial cancer by comparing levels between EC and non-cancer controls and analyzing diagnostic performance using ROC/AUC.\"},{\"question\":\"How many participants were included and how were they grouped?\",\"answer\":\"A total of 127 patients were included and divided into a study group with endometrial cancer and a control group with non-cancerous cases.\"},{\"question\":\"What were the main findings about vaspin levels?\",\"answer\":\"Vaspin levels were significantly lower in patients with endometrial cancer than in patients with benign endometrial lesions, supporting its potential role in differentiating benign lesions from EC.\"}]","Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer? | PDF",1790220407]