[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378632-105":59,"doc-detail-378632-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","could-there-be-an-interplay-between-periodontal-changes-and-pancreatic-malignancies-minireviews","Could there be an interplay between periodontal changes and pancreatic malignancies? - Minireviews","","“Periodontal disease” describes chronic inflammatory illnesses driven by microorganisms in subgingival biofilm that damage tooth-supporting tissues. Evidence also links periodontal infection to worsening systemic diseases at distant sites, supporting the oral cavity’s role in general health. Periodiopathogens may be translocated via hematogenous, enteral, or lymphatic routes, potentially promoting gastroenterological malignancies. Pancreatic cancer burden has risen, with periodontitis increasing risk and mortality. Periodontitis may influence PC via oral microbiome alterations and inflammation pathways.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/could-there-be-an-interplay-between-periodontal-changes-and-pancreatic-malignancies-minireviews/378632/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/could-there-be-an-interplay-between-periodontal-changes-and-pancreatic-malignancies-minireviews/378632.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the relationship between periodontal disease and systemic health mentioned in the document?","Question",{"text":113,"@type":114},"Periodontal infection is described as aggravating systemic disease states at distal sites, reinforcing the oral cavity’s importance for general health.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the article connect periodontitis with pancreatic cancer risk and mortality?",{"text":118,"@type":114},"Periodontitis is linked to at least a 50% increased risk of pancreatic cancer and considerably raises the chance of dying from it.",{"name":120,"@type":111,"acceptedAnswer":121},"What role does the oral microbiome play in pancreatic cancer as described here?",{"text":122,"@type":114},"Future pancreatic cancer risk is associated with oral microbiome changes, including higher Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and lower Leptotrichia and Fusobacteria, suggesting an impact on inflammatory conditions.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378632,1790666307,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2023 January 26; 11(3): 545-555  \nDOI: 10.12998/wjcc.v11.i3.545 ISSN 2307-8960 (online)  \nMINIREVIEWS  \nCould there be an interplay between periodontal changes and pancreatic malignancies?  \nBogdan Silviu Ungureanu, Dorin Nicolae Gheorghe, Flavia Mirela Nicolae, Sandu Râmboiu, Petru Adrian Radu, Valeriu Marin Șurlin, Victor Dan Eugen Strâmbu, Dan Ionut Gheonea, Alexandra Roman, Petra Șurlin  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B, B  \nGrade C (Good): 0  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Ksiazek M, Poland; Sun SY, China  \nReceived: November 18, 2022  \nPeer-review started: November 18, 2022  \nFirst decision: December 10, 2022  \nRevised: December 19, 2022  \nAccepted: January 10, 2023  \nArticle in press: January 10, 2023  \nPublished online: January 26, 2023  \nBogdan Silviu Ungureanu, Dan Ionut Gheonea, Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania  \nDorin Nicolae Gheorghe, Flavia Mirela Nicolae, Petra Șurlin, Department of Periodontology, Research Center of Periodontal-Systemic Implications, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania  \nSandu Râmboiu, Valeriu Marin Șurlin, Department 1st of Surgery, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania  \nPetru Adrian Radu, Victor Dan Eugen Strâmbu, Department of General Surgery,“Carol Davila”University of Medicine and Pharmacy, Bucharest 020021, Romania  \nAlexandra Roman, Department of Periodontology, \"Iuliu Hațieganu\" University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania  \nCorresponding author: Flavia Mirela Nicolae, MD, Doctor, Researcher, Department of Periodontology, Research Center of Periodontal-Systemic Implications, University of Medicine and Pharmacy of Craiova, Str. Petru Rareș, nr. 2, Craiova 200349, Romania.  \n[flavia.nicolae23@yahoo.com](flavia.nicolae23@yahoo.com)  \nAbstract  \nThe term \"periodontal disease\" refers to a group of chronic inflammatory illnesses caused by specific microorganisms from subgingival biofilm, that affect the toothsupporting tissues. Recent research has also shown that periodontal infection plays a role in aggravating systemic disease states at distal sites, reinforcing the significance of the oral cavity for general health. Additionally, it has been suggested that gastroenterological malignancies may be promoted by hematogenous, enteral or lymphatic translocation of periopathogens. In the past 25 years, the global burden of pancreatic cancer (PC) has more than doubled, making it oneof the major causes of cancer-related mortality. Periodontitis has been linked to at least 50% increased risk of PC and it could be considered a risk factor for this malignancy. A recent study performed on 59000 African American women with a follow up of 21 years showed that participants who had poor dental health had higher chances of PC. The findings, according to researchers, might be related to the inflammation that some oral bacteria trigger. Regarding the mortality of PC, periodontitis considerably raises the chance of dying from PC. Microbiome  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 545 January 26, 2023  Volume 11  Issue 3   \nUngureanu BS et al. Periodontal changes and pancreatic malignancies  \nalterations in the gut, oral cavity and pancreatic tissues of PC patients occur when compared to healthy flora, demonstrating a link between PC and microecology. Inflammation may also contribute to PC development, although the underlying pathway is not yet known. The function of the microbiome in PC risk has","cbCain8iTSz8GkJ9","https://ap.wps.com/l/cbCain8iTSz8GkJ9","pdf",541297,"English","# Could there be an interplay between periodontal changes and pancreatic malignancies?\n## Abstract\n## Key Words\n## Core Tip\n## Citation","[{\"question\":\"What is the relationship between periodontal disease and systemic health mentioned in the document?\",\"answer\":\"Periodontal infection is described as aggravating systemic disease states at distal sites, reinforcing the oral cavity’s importance for general health.\"},{\"question\":\"How does the article connect periodontitis with pancreatic cancer risk and mortality?\",\"answer\":\"Periodontitis is linked to at least a 50% increased risk of pancreatic cancer and considerably raises the chance of dying from it.\"},{\"question\":\"What role does the oral microbiome play in pancreatic cancer as described here?\",\"answer\":\"Future pancreatic cancer risk is associated with oral microbiome changes, including higher Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and lower Leptotrichia and Fusobacteria, suggesting an impact on inflammatory conditions.\"}]","Could there be an interplay between periodontal changes and pancreatic malignancies? - Minireviews | PDF",1790231616]