[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377062-105":59,"doc-detail-377062-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","could-cannabinoids-provide-a-new-hope-for-ovarian-cancer-patients","Could cannabinoids provide a new hope for ovarian cancer patients?","","Gynecological cancers remain a major global health burden, and ovarian cancer in particular faces high morbidity, mortality, and unmet clinical needs. Cannabinoids from Cannabis sativa have long been used symptomatically and show anti-cancer activity, including anti-proliferative and pro-apoptotic effects through multiple mechanisms. Conventional therapies still cause toxicity and recurrence, while cannabinoids may offer improved tolerability. Because psychoactive effects can restrict progress, non-psychoactive cannabinoids are gaining research interest, with promising pre-clinical ovarian cancer findings yet unanswered questions and research gaps.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/could-cannabinoids-provide-a-new-hope-for-ovarian-cancer-patients/377062/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/could-cannabinoids-provide-a-new-hope-for-ovarian-cancer-patients/377062.png","ImageObject",300,407,{"name":92,"@type":93},"Angel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are new ovarian cancer treatments needed?","Question",{"text":112,"@type":113},"Ovarian cancer shows high morbidity and mortality and continues to face unfavorable outcomes. Tumor recurrence, drug resistance, and toxic effects remain major challenges, indicating unmet clinical needs.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What anti-cancer effects do cannabinoids have?",{"text":117,"@type":113},"Cannabinoids can exert anti-cancer activity, including anti-proliferative and pro-apoptotic effects, via multiple mechanisms. They are also discussed as potential therapies that modulate intracellular signaling pathways involved in cancer progression.",{"name":119,"@type":110,"acceptedAnswer":120},"Why focus on non-psychoactive cannabinoids?",{"text":121,"@type":113},"Psychoactive effects of cannabinoids could limit their development and clinical use. Non-psychoactive cannabinoids attract pharmacological interest because they cannot produce psychological effects, and they show promising pre-clinical results in ovarian cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377062,1790342568,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687207412472,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Received: 27 March 2023 | Accepted: 5 July 2023  \nDOI: 10. 1002/prp2 .1122  \nRE V I E W  \nCould cannabinoids provide a new hope for ovarian cancer patients?  \nRimanee Kaur | Farideh A. Javid   \nDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, UK  \nCorrespondence  \nFarideh A. Javid, Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK.  \nEmail: [fajavid@hud.ac.uk](fajavid@hud.ac.uk)  \nAbstract  \nIt is known that gynecological cancers remain a worldwide problem and as shown by the statistics, there is a need for new gynecological cancer treatments. Cannabinoids, the pharmacologically active compounds of the Cannabis sativa plant, have been used for many centuries by individuals as a symptomatic treatment to alleviate pain, nausea, vomiting, and to help stimulate appetite. Research has revealed that cannabinoids also exert anti-cancer activity such as anti-proliferative and pro-apoptotic effects through a variety of mechanisms. There is significant value in the development of these compounds as anti-cancer therapies in clinical practice as they do not produce the typical toxic side effects that exist with conventional therapies and recent clinical trials have shown their great tolerability by patients at high doses. Cannabinoids can induce psychoactive effects that could limit their progression. Therefore, non-psychoactive cannabinoids are attracting pharmacological interest due to their inability to produce psychological effects. Recent studies have focussed on non-psychoactive cannabinoids in ovarian cancer and have revealed promising pre-clinical results that indicate that these compounds may have potential benefits in the treatment of these cancers. However, there are still unanswered questions and research gaps that need to be addressed. This review summarizes the current understanding of this topic and identifies the current gaps in knowledge that provide a useful direction for future work.  \nK E Y WO R D S  \ncannabinoids, non-psychoactive cannabinoids, ovarian cancer  \n\n| Abbreviations: 2-AG, 2-arachidonoylglycerol; 2-AGE, 2-arachidonoyl glyceryl ether; AEA-ANANDAMIDE, N-arachidonoylethanolamine; AKT, Protein Kinase B; CB1, Cannabinoid receptor 1; CB2, Cannabinoid receptor 2; CBC, Cannabichromene; CBCV, Cannabichromevarin; CBD, Cannabidiol; CBDV, Cannabidivarin; CBG, Cannabigerol; CBGM, Cannabigerol monoethyl ether; CBGV, Cannabigerovarin; CBL, Cannabicyclol; CBV, Cannabivarin; CDK2, Cyclin-dependent kinase 2; CNS, Central Nervous System; ECS, Endocannabinoid System; EGF, Epithelial Growth Factor; EGFR, Epithelial Growth Factor Receptor; ER, Endoplasmic Reticulum; ERK, Extracellular Signal-Regulated Kinase; FAAH, Fatty acid amide hydrolase; FSH, Follicle-stimulating Hormone; GnRH, Gonadotropin-releasing hormone; GPR55, G protein-coupled receptor 55; HDAC, Histone deacetylase; IAP, Inhibitors of Apoptosis Proteins; LH, Luteinizing hormone; MAGL, Monoacylglycerol lipase; mTOR, Mammalian target of rapamycin; NADA, N-arachidonoyldopamine; NAGly, N-arachidonylglycine; OA, Oleic acid amide; PI3K, Phosphatidylinositol 3-kinase; PPARs, Peroxisome proliferator-activated Receptors; ROS, Reactive oxygen species; THC, Δ9-tetrahydrocannabinol; THCV, Tetrahydrocannabivarin; TRP, Transient receptor potential; TRPV1, Transient receptor potential vanilloid subtype 1; XIAP, X-linked inhibitor of apoptosis protein. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>© 2023 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. |\n\nPharmacol Res Perspect. 2023;11:e01122 . [https://doi.org/10.1002/prp2.1122](https://doi.org/10.1002/prp2.1122)  \n[wileyonl","cbCaihCQR08n44vY","https://ap.wps.com/l/cbCaihCQR08n44vY","pdf",850271,13,"English","# Introduction\n# Current clinical status","[{\"question\":\"Why are new ovarian cancer treatments needed?\",\"answer\":\"Ovarian cancer shows high morbidity and mortality and continues to face unfavorable outcomes. Tumor recurrence, drug resistance, and toxic effects remain major challenges, indicating unmet clinical needs.\"},{\"question\":\"What anti-cancer effects do cannabinoids have?\",\"answer\":\"Cannabinoids can exert anti-cancer activity, including anti-proliferative and pro-apoptotic effects, via multiple mechanisms. They are also discussed as potential therapies that modulate intracellular signaling pathways involved in cancer progression.\"},{\"question\":\"Why focus on non-psychoactive cannabinoids?\",\"answer\":\"Psychoactive effects of cannabinoids could limit their development and clinical use. Non-psychoactive cannabinoids attract pharmacological interest because they cannot produce psychological effects, and they show promising pre-clinical results in ovarian cancer.\"}]","Could cannabinoids provide a new hope for ovarian cancer patients? | PDF",1790222927,33]