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This systematic review and meta-analysis compiled data from prospective cohorts, randomized controlled trials, and observational studies on upper-face BoNT-A injections, evaluating safety, effectiveness, patient satisfaction, and response rates using random-effects models. Ten trials showed reduced wrinkle severity, while satisfaction and response outcomes demonstrated substantial heterogeneity and possible publication bias.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cosmetic-botulinum-toxin-a-injections-to-the-upper-face-a-systematic-review-and-meta-analysis-of-clinical-studies/468274/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cosmetic-botulinum-toxin-a-injections-to-the-upper-face-a-systematic-review-and-meta-analysis-of-clinical-studies/468274.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main focus of the systematic review on BoNT-A injections?","Question",{"text":113,"@type":114},"The review evaluated upper-face BoNT-A injection clinical research, emphasizing safety outcomes, effectiveness, patient satisfaction, and response rates.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which areas of the upper face were considered in the included studies?",{"text":118,"@type":114},"The included studies targeted dynamic wrinkles in the glabellar, forehead, and periorbital regions of the upper face.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the meta-analysis find regarding wrinkle severity and patient satisfaction?",{"text":122,"@type":114},"Wrinkle severity ratings decreased after BoNT-A therapy, but patient satisfaction showed substantial variability across trials with high heterogeneity and possible publication bias.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},468274,1791037215,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":36,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Journal of Cosmetic Dermatology  \nCosmetic Botulinum Toxin A Injections to the Upper Face: A Systematic Review and Meta-Analysis of Clinical Studies  \nAlaa Safia1  | Uday Abd Elhadi1 | Shlomo Merchavy1 | Ramzy Batheesh2 | Naji Bathish3  \n1Department of Otolaryngology, Ziv Medical Center, Safed, Israel | 2Department of Dermatology, Rambam Health Care Campus, Haifa,  \nIsrael | 3Department of Dermatology, Ziv Medical Center, Safed, Israel Correspondence: Alaa Safia ([alaa.safia03@gmail.com](alaa.safia03@gmail.com))  \nReceived: 9 September 2025 | Revised: 28 November 2025 | Accepted: 22 December 2025  \nKeywords: BoNT-A injections | cosmetic injections | heterogeneity | patient's satisfaction | publication bias | response rate | upper face aesthetics BoNT-A therapy | wrinkle severity scale  \nABSTRACT  \nBackground: Botulinum toxin type A (BoNT-A) is widely recognized as the leading nonsurgical cosmetic treatment worldwide for diminishing dynamic wrinkles in the glabellar, forehead, and periorbital areas. While BoNT-A is widely acknowledged for its effectiveness and popularity, there are notable inconsistencies in results, methodologies, and safety reporting across clinical studies, highlighting the necessity for the careful development of strong, evidence-driven guidelines.  \nObjectives: This study aimed to compile and evaluate data from clinical research focusing on upper-face BoNT-A injections, specifically regarding safety outcomes, effectiveness, patient satisfaction, and response rates. This investigation concentrated on the outcomes of the clinical trials conducted.  \nMethods: This analysis includes prospective cohorts, randomized controlled trials, and observational studies that report on BoNT-A cosmetic treatments specifically in the upper face area. A thorough examination of MEDLINE, EMBASE, Cochrane Library, and Web of Science studies was conducted, covering literature up to May 2025. The assessment included response rates, levels of patient satisfaction, and the extent of wrinkle reduction. The analysis employed a random-effects model to produce combined estimates, followed by an assessment of heterogeneity utilizing τ2 , I2 , and Cochran's Q. Forest diagrams and Egger's test were utilized to evaluate publication bias and the effects of small studies when applicable.  \nResults: After the administration of BoNT-A therapy, a notable decrease in the severity ratings of wrinkles was observed, as indicated by the synthesis of ten clinical trials examining this aspect (Cohen's d = 1.93; 95% CI: 1.60–2.25; p = 0.001) . However, the data also revealed a considerable degree of variability (I2 = 90%). The findings indicated substantial variability in effect sizes related to patient satisfaction across four distinct trials (Cohen's d = 22.54; 95% CI: −2.07–47.15; p = 0.07), accompanied by significant heterogeneity (I2 = 99.9%) and potential indications of publication bias. The findings revealed significant variability (I2 = 100%) and wide prediction intervals, indicating substantial inconsistency and limited applicability of the response outcomesin future research. Analysis of five studies regarding response rates revealed a significant overall effect (Cohen's d = 34.30; 95% CI: 3.65–64.94; p = 0.28) . The overall impact was determined to be noteworthy.  \nConclusions: BoNT-A injections contribute to a decrease in wrinkle severity and improve clinical results for rejuvenating the upper face. Research indicates notable variability and susceptibility to bias regarding patient satisfaction and response rates. The findings emphasize the necessity for subgroup analyses, enhanced reporting methodologies, and uniform outcome evaluationsto identify factors contributing to variability in responses to BoNT-A therapy.  \nTrial Registration: This study was conducted in accordance with PROSPERO guidelines  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction i","cbCaipcRFJxmsUgB","https://ap.wps.com/l/cbCaipcRFJxmsUgB","pdf",1324229,16,"English","# Abstract\n## Background\n## Objectives\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the main focus of the systematic review on BoNT-A injections?\",\"answer\":\"The review evaluated upper-face BoNT-A injection clinical research, emphasizing safety outcomes, effectiveness, patient satisfaction, and response rates.\"},{\"question\":\"Which areas of the upper face were considered in the included studies?\",\"answer\":\"The included studies targeted dynamic wrinkles in the glabellar, forehead, and periorbital regions of the upper face.\"},{\"question\":\"What did the meta-analysis find regarding wrinkle severity and patient satisfaction?\",\"answer\":\"Wrinkle severity ratings decreased after BoNT-A therapy, but patient satisfaction showed substantial variability across trials with high heterogeneity and possible publication bias.\"}]","Cosmetic Botulinum Toxin A Injections to the Upper Face - A Systematic Review and Meta-Analysis of Clinical Studies | PDF",1790773981]