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The corrected Fig. 5 is provided in the original publication. The authors state the correction does not alter the article’s results or conclusions. The figure summary includes JAK/STAT pathway activation, protein expression analyses, interaction assays, western blot changes under sc-43 and garcinone D, and functional assays (CCK8, EdU, transwell, PI staining).",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/correction-correction-the-positive-feedback-loop-of-mad2l1tyk2stat3-induces-progression-in-b-cell-acute-lymphoblastic-leukaemia/430609/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/correction-correction-the-positive-feedback-loop-of-mad2l1tyk2stat3-induces-progression-in-b-cell-acute-lymphoblastic-leukaemia/430609.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the specific issue in the original article’s Fig. 5?","Question",{"text":112,"@type":113},"In Fig. 5i, the data representing Nalm6 cells (bottom left) was inadvertently a duplicate of data presented in Fig. 5j.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Does the correction change the study’s overall conclusions?",{"text":117,"@type":113},"No. The correction does not affect the results or conclusions of the article.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the corrected Fig. 5 cover experimentally?",{"text":121,"@type":113},"Fig. 5 summarizes JAK/STAT pathway-related findings, including GSEA enrichment, western blot and protein level assessments, Co-IP analysis, treatment effects with sc-43 and garcinone D, and functional assays such as CCK8/EdU and transwell migration/invasion plus PI staining.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},430609,1790815495,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","Journal of Cancer Research and Clinical Oncology (2026) 152:27  \n[https://doi.org/10.1007/s00432-025-06392-7](https://doi.org/10.1007/s00432-025-06392-7)  \nCORRECTION  \nCorrection: The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia  \nLiwen Zhu1,2 · Xinyu Li1,2 · Diandian Liu1,2 · Wenke Bai1,2 · Huaqing Yang1,2 · Qianyi Cheng1,2 · Luhong Xu1,2 · Jianpei Fang1,2  \n© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026  \nJournal of Cancer Research and Clinical Oncology  \n(2023) 149:6527-6540 [https://doi.org/10.1007/s00432-02](https://doi.org/10.1007/s00432-02)[ ](https://doi.org/10.1007/s00432-02)3-04613-5  \nIn Fig. 5i of this article, the data representing Nalm6 cells (bottom left) was inadvertently a duplicate of data presented in Fig. 5j. Figure 5 has now been corrected in the original publication. For completeness and transparency, both the  \nThe original article can be found online at [https://doi.org/10.1007/s00](https://doi.org/10.1007/s00)[ ](https://doi.org/10.1007/s00)432-023-04613-5.  \n􀀍 Luhong Xu [xulhong@mail.sysu.edu.cn](xulhong@mail.sysu.edu.cn)  \n􀀍 Jianpei Fang [fangjpei@mail.sysu.edu.cn](fangjpei@mail.sysu.edu.cn)  \n1 Department of Pediatrics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou 510120, Guangdong, People’s Republic of China  \n2 Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China  \ncorrect and incorrect versions are displayed below. The correction does not affect the results or conclusions of the article.  \n1 3  \nCorrect Fig. 5.  \nFig. 5 MAD2L1 promotes B-ALL proliferation and metastasis through the JAK/STAT signaling pathway. A GSEA demonstrated significant enrichment of the JAK/STAT pathway correlating with MAD2L1 expression. B Protein levels of JAK1, p-JAK1, JAK2, p-JAK2, JAK3 and p-JAK3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. C Protein levels of TYK2, p-TYK2, STAT3 and p-STAT3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. D Co-IP analysis of MAD2L1 interacting proteins. E Western blot analysis showed that MAD2L1, TYK2, p-TYK2, STAT3 and p-STAT3 expression levels were modified by sc-43 and garcinone D treatment of B-ALL cells.  \nF–H The CCK8 assay and EdU suggested that sc-43 or garcinone D modified the effect of MAD2L1 upregulation or downregulation on the cell proliferation ability of RS4;11 or Nalm6 cells. I, J The transwell assay demonstrated that sc-43 or garcinone D modified the migration and invasion capability due to MAD2L1 overexpression or downregulation in RS4;11 or Nalm6 cells. K, L Representative histograms of PI staining in the vector, ovMAD2L1 and MAD2L1 + sc-43 of RS4;11 and shNC, shMAD2L1 and shMAD2L1 +garcinone D ofNalm6 cells. Data are shown as the mean ± SD. *p \u003C 0.05, **p \u003C 0.01, ***p \u003C 0.001 and ****p \u003C 0.0001  \nIncorrect Fig. 5.  \nFig. 5 MAD2L1 promotes B-ALL proliferation and metastasis through the JAK/STAT signaling pathway. A GSEA demonstrated significant enrichment of the JAK/STAT pathway correlating with MAD2L1 expression. B Protein levels of JAK1, p-JAK1, JAK2, p-JAK2, JAK3 and p-JAK3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. C Protein levels ofTYK2, p-TYK2, STAT3 and p-STAT3 in B-ALL cells with MAD2L1 overexpression or knockdown were analysed via western blot. D Co-IP analysis of MAD2L1 interacting proteins. E Western blot analysis showed that MAD2L1, TYK2, p-TYK2, STAT3 and p-STAT3 expression levels were modified by sc-43 and garcinone D treatment of B-ALL cells. F–H The CCK8 assay and EdU suggested that sc-43 or garcinone D modified the effect of MAD2L1 upregulation or downregulation on the cell proliferation ability of RS4;11 or Nalm6 cells. I, J The t","cbCaijG3ptqAbPSL","https://ap.wps.com/l/cbCaijG3ptqAbPSL","pdf",1309525,"English","# Correction Notice\n## Error in Fig. 5i and Provided Correction\n## Figure 5: Correct vs Incorrect Panel Descriptions","[{\"question\":\"What was the specific issue in the original article’s Fig. 5?\",\"answer\":\"In Fig. 5i, the data representing Nalm6 cells (bottom left) was inadvertently a duplicate of data presented in Fig. 5j.\"},{\"question\":\"Does the correction change the study’s overall conclusions?\",\"answer\":\"No. The correction does not affect the results or conclusions of the article.\"},{\"question\":\"What does the corrected Fig. 5 cover experimentally?\",\"answer\":\"Fig. 5 summarizes JAK/STAT pathway-related findings, including GSEA enrichment, western blot and protein level assessments, Co-IP analysis, treatment effects with sc-43 and garcinone D, and functional assays such as CCK8/EdU and transwell migration/invasion plus PI staining.\"}]","Correction - Correction: The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia | PDF",1790653278]