[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-25826-105":59,"doc-detail-25826-en":107},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":100,"head_meta":102,"extra_data":104,"updated_unix":106},105,"en","coronary-artery-diseases-chronic-stable-angina","Coronary Artery Diseases Chronic Stable Angina","","This document outlines the progression of coronary artery disease (CAD) and its associated histopathological changes, providing a comprehensive overview of atherosclerosis from its initial stages to complicated lesions. It details the nomenclature and main histology of six lesion types (Type I to Type VI), illustrating their appearance and characteristics. The document further elaborates on the sequences in progression, highlighting the main growth mechanisms, earliest onset, and clinical correlations for each stage. Specifically, it notes that Type I lesions (initial lesions) consist of isolated macrophage foam cells, appearing from the first decade and are clinically silent. Type II lesions (fatty streak lesions), characterized by mainly intracellular lipid accumulation, also manifest from the first decade and remain clinically silent. Type III lesions (intermediate lesions) show Type II changes and small extracellular lipid pools, developing from the third decade. Type IV lesions (atheroma) involve Type II changes and the core of extracellular lipid, emerging from the third decade. Type V lesions (fibroatheroma) are defined by a lipid core and fibrotic layer, or multiple lipid cores and fibrotic layers, or mainly calcific/fibrotic structures, with accelerated smooth muscle and collagen increase, appearing from the fourth decade with clinically silent or overt manifestations. Finally, Type VI lesions (complicated lesions) present with surface defects, hematoma-hemorrhage, and thrombus, also driven by thrombosis and hematoma, and are clinically overt. The document also touches upon coronary circulation, emphasizing that coronary flow occurs mainly during diastole. It states that normal coronaries can increase blood flow 4-7 times during maximum exercise, and stenosis does not limit flow until the cross-sectional area of the vessel is reduced by at least 70%. A reduction of over 90% in diameter may cause angina at rest. The role of small collateral vessels in interconnecting coronary arteries, which become functional only when a coronary artery is stenosed, is also mentioned. The primary cause of CAD is identified as atherosclerosis and its complications, particularly thrombosis. Additionally, factors influencing myocardial O2 supply and demand, causes of CAD, and drugs like cocaine, sumtriptan, and paclitaxel are listed as potential contributors. The document concludes by referencing the stages of atherosclerosis and the pathophysiology of CAD.",{"@graph":69,"@context":99},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/coronary-artery-diseases-chronic-stable-angina/25826",{"url":83,"name":65,"@type":85,"author":86,"headline":65,"publisher":89,"fileFormat":92,"description":67,"dateModified":93,"datePublished":93,"encodingFormat":92,"isAccessibleForFree":94,"interactionStatistic":95},"DigitalDocument",{"name":87,"@type":88},"Violet","Person",{"url":74,"name":90,"@type":91},"DocShare","Organization","application/pdf","2026-05-07",true,{"@type":96,"interactionType":97,"userInteractionCount":4},"InteractionCounter",{"@type":98},"ViewAction","https://schema.org",{"og:url":83,"og:type":101,"og:title":65,"og:site_name":90,"og:description":67},"article",{"robots":103,"canonical":83},"index,follow",{"doc_id":105,"site_id":62},25826,1778194813,{"code":4,"msg":5,"data":108},{"doc_id":105,"user_id":109,"nickname":87,"user_avatar":110,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":111,"file_url":112,"file_type":113,"file_size":114,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":115,"language":116,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":117,"seo_description":67,"update_tm":106,"read_time":118},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","cbCaibBcMC9LKMm9","https://ap.wps.com/l/cbCaibBcMC9LKMm9","pdf",2676247,62,"English","Coronary Artery Diseases Chronic Stable Angina | PDF",156]