[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31475":3,"doc-seo-31475":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31475,4398048949847,"Eliana","https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267",8,"Research & Report","Core–Shell Metal–Organic Frameworks with pH/GSH Dual-Responsiveness for Combined Chemo–Chemodynamic Therapy","A core–shell metal–organic framework (MOF) platform, Cu-MOF@SMON/DOX-HA, is designed for combined chemo–chemodynamic therapy by integrating high drug loading, pH/GSH dual-responsive degradation, and good biocompatibility. Organosilicon SMON is modified on Cu-MOF to deplete glutathione (GSH) and amplify oxidative stress, triggering ferroptosis and controlled DOX release. Hyaluronic acid (HA) improves HepG2 targeting, while Cu2+ drives Fenton-like ROS generation and 3-AT inhibits catalase to enhance chemodynamic therapy.","cbCainnIFR2CFOii","https://ap.wps.com/l/cbCainnIFR2CFOii","pdf",1483745,1,4,"English","en","# Abstract\n## Background and therapeutic rationale\n## Core–shell MOF design and components\n## Preparation workflow and targeting strategy\n## Proposed mechanism for CDT/CT efficacy","[{\"question\":\"What is the main purpose of the Cu-MOF@SMON/DOX-HA design?\",\"answer\":\"To achieve combined chemo–chemodynamic therapy with high drug loading and dual responsiveness to pH and GSH, while maintaining good biocompatibility.\"},{\"question\":\"How does the system trigger ferroptosis?\",\"answer\":\"Cu-MOF@SMON/DOX-HA depleted intracellular GSH to decompose the SMON shell, release DOX, reduce GSH levels, and promote ferroptosis.\"},{\"question\":\"How does the chemodynamic therapy component generate cytotoxic ROS?\",\"answer\":\"Under mild acidic conditions, released Cu2+ catalyzes H2O2 via a Fenton-like reaction to produce cytotoxic hydroxyl radicals (•OH), and 3-AT inhibits catalase to further enhance ROS generation.\"}]",1779570062,10,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":83,"head_meta":85,"extra_data":87,"updated_unix":25},105,"coreshell-metalorganic-frameworks-with-phgsh-dual-responsiveness-for-combined-chemochemodynamic-therapy","",{"@graph":34,"@context":82},[35,51,65],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":20},"https://docshare.wps.com/document/coreshell-metalorganic-frameworks-with-phgsh-dual-responsiveness-for-combined-chemochemodynamic-therapy/31475/",{"url":50,"name":13,"@type":52,"author":53,"headline":13,"publisher":55,"fileFormat":58,"description":14,"dateModified":59,"datePublished":59,"encodingFormat":58,"isAccessibleForFree":60,"interactionStatistic":61},"DigitalDocument",{"name":9,"@type":54},"Person",{"url":39,"name":56,"@type":57},"DocShare","Organization","application/pdf","2026-05-23",true,{"@type":62,"interactionType":63,"userInteractionCount":4},"InteractionCounter",{"@type":64},"ViewAction",{"@type":66,"mainEntity":67},"FAQPage",[68,74,78],{"name":69,"@type":70,"acceptedAnswer":71},"What is the main purpose of the Cu-MOF@SMON/DOX-HA design?","Question",{"text":72,"@type":73},"To achieve combined chemo–chemodynamic therapy with high drug loading and dual responsiveness to pH and GSH, while maintaining good biocompatibility.","Answer",{"name":75,"@type":70,"acceptedAnswer":76},"How does the system trigger ferroptosis?",{"text":77,"@type":73},"Cu-MOF@SMON/DOX-HA depleted intracellular GSH to decompose the SMON shell, release DOX, reduce GSH levels, and promote ferroptosis.",{"name":79,"@type":70,"acceptedAnswer":80},"How does the chemodynamic therapy component generate cytotoxic ROS?",{"text":81,"@type":73},"Under mild acidic conditions, released Cu2+ catalyzes H2O2 via a Fenton-like reaction to produce cytotoxic hydroxyl radicals (•OH), and 3-AT inhibits catalase to further enhance ROS generation.","https://schema.org",{"og:url":50,"og:type":84,"og:title":13,"og:site_name":56,"og:description":14},"article",{"robots":86,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]