[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331369-105":59,"doc-detail-331369-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","copper-homeostasis-and-cuproptosis-in-gynecological-cancers","Copper homeostasis and cuproptosis in gynecological cancers","","Copper (Cu) is a vital trace element that supports antioxidant defense, mitochondrial respiration, and biochemical synthesis, while maintaining strict homeostasis in the body. Cuproptosis is presented as a Cu-driven programmed cell death mechanism distinct from apoptosis, ferroptosis, and necroptosis. Excess Cu can enhance gynecological cancer progression, yet research linking cuproptosis to these malignancies remains limited. This review summarizes Cu homeostasis, cuproptosis biology, and its potential for prognosis prediction and therapeutic implications, including Cu ionophore therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/copper-homeostasis-and-cuproptosis-in-gynecological-cancers/331369/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/copper-homeostasis-and-cuproptosis-in-gynecological-cancers/331369.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is cuproptosis and how is it triggered by copper?","Question",{"text":112,"@type":113},"Cuproptosis is a novel form of cell death induced by excessive copper. It depends on mitochondrial respiration and is initiated by Cu+ binding to lipoylated enzymes in the TCA cycle, leading to DLAT oligomerization and downstream loss of Fe–S clusters with HSP70 induction.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does copper imbalance relate to gynecological cancers?",{"text":117,"@type":113},"Excess copper can promote cancer progression by supporting tumor growth, proliferation, angiogenesis, and metastasis through multiple signaling pathways. The review notes that intratumoral copper levels and altered systemic copper distribution have been observed in cancers.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic directions does the review discuss?",{"text":121,"@type":113},"The review explores the potential use of cuproptosis for prognosis prediction and examines implications for progression and treatment of gynecological cancers, including the application of copper ionophore therapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331369,1790530363,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","TYPE Review  \nPUBLISHED 25 September 2024 DOI 10.3389/fcell.2024.1459183  \nOPEN ACCESS  \nEDITED BY  \nMing Yi,  \nZhejiang University, China  \nREVIEWED BY  \nQian Yang,  \nZhejiang University, China Ruidi Yu,  \nHuazhong University of Science and Technology, China  \n*CORRESPONDENCE  \nChangzhong Li,  \n [15168888909@163.com](15168888909@163.com)  \nRECEIVED 03 July 2024  \nACCEPTED 06 September 2024  \nPUBLISHED 25 September 2024  \nCITATION  \nHuang X, Lian M and Li C (2024) Copper homeostasis and cuproptosis in gynecological cancers.  \nFront. Cell Dev. Biol. 12:1459183 .  \ndoi: 10.3389/fcell.2024.1459183  \nCOPYRIGHT  \n© 2024 Huang, Lian and Li. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nCopper homeostasis and cuproptosis in gynecological cancers  \nXiaodi Huang 1,2,3, Mengyi Lian 4 and Changzhong Li 1,2,3*  \n1Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China, 2Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, China, 3Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, China, 4Department of Obstetrics and Gynecology, Longquan People’s Hospital, Lishui, China  \nCopper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and biocompound synthesis. In recent years, a novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death. Cu targetslipoylated enzymes in the tricarboxylic acid cycle and subsequently triggers the oligomerization of lipoylated dihydrolipoamide S-acetyltransferase, leading to the loss of Fe–S clusters and induction of heat shock protein 70 . Gynecological malignancies including cervical cancer, ovarian cancer and uterine corpus endometrial carcinoma significantly impact women’s quality of life and even pose a threat to their lives. Excessive Cu can promote cancer progression by enhancing tumor growth, proliferation, angiogenesis and metastasis through multiple signaling pathways. However, there are few studies investigating gynecological cancers in relation to cuproptosis. Therefore, this review discusses Cu homeostasis and cuproptosis while exploring the potential use of cuproptosis for prognosis prediction as well as its implications in the progression and treatment of gynecological cancers. Additionally, we explore the application of Cu ionophore therapy in treating gynecological malignancies.  \nKEYWORDS  \ncopper homeostasis, cuproptosis, gynecological cancers, prognosis prediction, functional analysis, copper ionophore  \n1 Introduction  \nAs an essential trace element, copper (Cu) plays a pivotal role in various biological processes, encompassing antioxidant defense, mitochondrial respiration, and biocompound synthesis (Chen et al., 2022) . Within the human body, Cu maintains a delicate equilibrium and achieves homeostasis. Furthermore, the accumulation of Cu is associated with the manifestation of Wilson disease, a severe hereditary disorder (Walshe, 2007). Recently elucidated by Tsvetkov et al. (2022) in March 2022, cuproptosis represents a novel mechanism of cell death induced by excessive Cu ions. This phenomenon is distinct from other forms of programmed cell death such as apoptosis, ferroptosis, and necroptosisand relies on mitochondrial respiration. Specifically targeting lipoylated enzymes within the tricarboxylic acid (TCA) cycle primarily through Cu+ ions binding to them leads to subsequent oligomerization of lipoylated dihydrolipoamide S-acetyltransferase (DLAT), loss ofFe-S cl","cbCaidn6C9VdBEso","https://ap.wps.com/l/cbCaidn6C9VdBEso","pdf",1072526,13,"English","# Introduction\n# Copper homeostasis and cuproptosis in gynecological cancers","[{\"question\":\"What is cuproptosis and how is it triggered by copper?\",\"answer\":\"Cuproptosis is a novel form of cell death induced by excessive copper. It depends on mitochondrial respiration and is initiated by Cu+ binding to lipoylated enzymes in the TCA cycle, leading to DLAT oligomerization and downstream loss of Fe–S clusters with HSP70 induction.\"},{\"question\":\"How does copper imbalance relate to gynecological cancers?\",\"answer\":\"Excess copper can promote cancer progression by supporting tumor growth, proliferation, angiogenesis, and metastasis through multiple signaling pathways. The review notes that intratumoral copper levels and altered systemic copper distribution have been observed in cancers.\"},{\"question\":\"What therapeutic directions does the review discuss?\",\"answer\":\"The review explores the potential use of cuproptosis for prognosis prediction and examines implications for progression and treatment of gynecological cancers, including the application of copper ionophore therapy.\"}]","Copper homeostasis and cuproptosis in gynecological cancers | PDF",1789992963,33]