[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-383613-105":59,"doc-detail-383613-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","contrast-enhanced-mammography-in-breast-cancer-surveillance","Contrast enhanced mammography in breast cancer surveillance","","Contrast Enhanced Mammography (CEM) is evaluated for women with a personal history of breast cancer (PHBC) in routine surveillance, where conventional mammography (MG) is supplemented by ultrasound. A retrospective Australian study assessed first-surveillance CEM cases between June 2006 and October 2020, including blinded re-reading of recalled examinations to estimate the added value of contrast. CEM showed higher sensitivity than MG, identified additional clinically significant malignant lesions, and interval cancer follow-up was recommended.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/contrast-enhanced-mammography-in-breast-cancer-surveillance/383613/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/contrast-enhanced-mammography-in-breast-cancer-surveillance/383613.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of using contrast enhanced mammography (CEM) in breast cancer surveillance?","Question",{"text":112,"@type":113},"To assess whether CEM provides better performance than standard mammography (MG) and MG supplemented with ultrasound in women with a personal history of breast cancer (PHBC).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study conducted and how were recalled cases handled?",{"text":117,"@type":113},"A retrospective study evaluated first surveillance CEM exams in an Australian hospital between June 2006 and October 2020. Recalled cases were identified and radiology, pathology, and treatment details were recorded, followed by blinded re-reading to determine the contribution of contrast.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key results when comparing CEM with MG (with or without ultrasound)?",{"text":121,"@type":113},"A portion of patients were recalled, including true and false positives. Many recalls were driven by contrast findings, and contrast-only true positives were found across mammographic density levels; breast ultrasound screening was reduced after CEM implementation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383613,1790718760,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Breast Cancer Research and Treatment (2023) 199:221–230  \n[https://doi.org/10.1007/s10549-023-06916-0](https://doi.org/10.1007/s10549-023-06916-0)  \nContrast enhanced mammography in breast cancer surveillance  \nKenneth Elder1 · Julia Matheson1 · Carolyn Nickson2,3 · Georgia Box1 · Jennifer Ellis1 · Arlene Mou4 · Clair Shadbolt4 · Allan Park4 · Jia Tay1 · Allison Rose4 · Gregory Bruce Mann1,4,5  \nReceived: 9 November 2022 / Accepted: 13 March 2023 / Published online: 25 March 2023 © The Author(s) 2023  \nAbstract  \nPurpose Mammography (MG) is the standard imaging in surveillance of women with a personal history of breast cancer or DCIS (PHBC), supplemented with ultrasound. Contrast Enhanced Mammography (CEM) has higher sensitivity than MG and US. We report the performance of CEM compared with MG ± US.  \nMethods A retrospective study of patients undergoing their first surveillance CEM in an Australian hospital setting between June 2006 and October 2020. Cases where a patient was recalled for assessment were identified, recording radiology, pathology and treatment details. Blinded re-reading of recalled cases was performed to determine the contribution of contrast. Use of surveillance US across the board was assessed for the period.  \nResults 73/1191 (6.1%) patients were recalled. 35 (48%) were true positives (TP), with 26 invasive cancers and 9 cases of DCIS, while 38 (52%) were false positive (FP) with a positive predictive value (PPV) 47.9% . 32/73 were recalled due to MG findings, while 41/73 were only recalled due to Contrast. 14/73 had ‘minimal signs’ with a lesion identifiable on MG with knowledge of the contrast finding, while 27/73 were visible only with contrast. 41%(17/41) recalled due to contrast were TP. Contrast-only TPs were found with low and high mammographic density (MD) . Screening breast US reduced by 55% in the year after CEM was implemented.  \nConclusion Compared to MG, CEM as a single surveillance modality for those with PHBC has higher sensitivity and comparable specificity, identifying additional malignant lesions that are clinically significant. Investigation of interval cancer and subsequent round outcomes is warranted.  \nKeywords Breast cancer · Surveillance · Mammography · Contrast · CEM  \nIntroduction  \nWomen with a personal history of breast cancer (PHBC) have an increased incidence of subsequent in-breast malignancy, either in the form of local recurrences after breast  \n* Kenneth Elder [Kenneth.elder@nhslothian.scot.nhs.uk](Kenneth.elder@nhslothian.scot.nhs.uk)  \n1 The Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne 3101, Australia  \n2 Daffodil Centre, The University of Sydney, a joint venture with Cancer Council New South Wales, Sydney, Australia  \n3 Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Australia  \n4 The Royal Women’s Hospital, Flemington Road, Parkville, Melbourne, Australia  \n5 Department of Surgery, The University of Melbourne, Parkville, Australia  \nconserving therapy or contralateral breast cancer [1]. Early detection of these events is associated with improved survival [2] . Breast cancers in patients with PHBC are twice as likely to be stage IIB or greater or to be node positive when compared with screen-detected cancers in the general population, which can translate into poorer outcomes [1, 3] . For this reason, breast imaging is a critical part of follow-up care. Clinical guidelines for women with PHBC universally recommend annual imaging, even where national guidelines for population screening may recommend 2-or 3-yearly imaging [4] .  \nMammography (MG) has been the foundation for surveillance after breast cancer for many years. Full field digital MG (2DMG) initially replaced analogue imaging, and more recently, digital breast tomosynthesis (3DMG) has become widespread, due to its improved cancer detection rate compared with 2DMG [5–7] .  \nIn recognition of false negatives if relying on MG alone, supplemental ultrasound ","cbCaigLFJc1e15Jy","https://ap.wps.com/l/cbCaigLFJc1e15Jy","pdf",1443999,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the purpose of using contrast enhanced mammography (CEM) in breast cancer surveillance?\",\"answer\":\"To assess whether CEM provides better performance than standard mammography (MG) and MG supplemented with ultrasound in women with a personal history of breast cancer (PHBC).\"},{\"question\":\"How was the study conducted and how were recalled cases handled?\",\"answer\":\"A retrospective study evaluated first surveillance CEM exams in an Australian hospital between June 2006 and October 2020. Recalled cases were identified and radiology, pathology, and treatment details were recorded, followed by blinded re-reading to determine the contribution of contrast.\"},{\"question\":\"What were the key results when comparing CEM with MG (with or without ultrasound)?\",\"answer\":\"A portion of patients were recalled, including true and false positives. Many recalls were driven by contrast findings, and contrast-only true positives were found across mammographic density levels; breast ultrasound screening was reduced after CEM implementation.\"}]","Contrast enhanced mammography in breast cancer surveillance | PDF",1790258389,25]